Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Patients and Families Improving Safety in Hospitals by Actively Reporting Experiences
NCT05407129
Recruiting
Hospitals ineffectively examine the safety of their processes by relying on voluntary incident reporting (VIR) by clinical staff who are overworked and afraid to report. VIR captures only 1-10% of events, excludes patients and families, and underdetects events in vulnerable groups like patients with language barriers. Patients and families are vigilant partners in care who are adept at identifying errors and AEs. Failing to actively include patients and families in safety reporting and instead r... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/24/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Family Reported Errors and Adverse Events, Health Disparities, Family Safety Reporting, Patient Safety, Voluntary Incident Reporting, Quality Improvement
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Mindfulness for Cognition in Early-stage Alzheimer's Disease
NCT06792877
Recruiting
The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and structure? 3. How does mindfulness affect daily function and quality of life? Researchers will compare all outcomes to one other groups. In one group, individuals will participate in a mindfulness class in... Read More
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
01/23/2025
Locations: VA Boston Healthcare System - Jamaica Plain Campus, Boston, Massachusetts
Conditions: Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, TBI (Traumatic Brain Injury), Aging, Healthy Elderly, Alzheimer's Dementia (AD)
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Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
NCT05706766
Recruiting
The goal of this research study is to investigate whether a virtual, home-based, prehabilitation aerobic and resistance exercise (PARE) training program implemented 8 weeks prior to receiving autologous stem cell transplant (ASCT) for multiple myeloma participants will improve muscular strength, physical capacity, patient reported outcomes, and cardiometabolic health outcomes. The names of the study interventions involved in this study are: * Prehabilitative aerobic and resistance exercise (PA... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Multiple Myeloma, Stem Cell Transplant Complications
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Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy
NCT05327465
Recruiting
The purpose of this research is to determine whether a 16-week culturally tailored, technology-based, aerobic and resistance exercise intervention improves cardiovascular risk factors in Black men diagnosed with prostate cancer and are undergoing androgen deprivation therapy (ADT), and whether it will also improve physical fitness and function, body composition, and outcomes such as quality of life, cancer symptoms, and self-esteem. Participants in this study will be randomly assigned to one of... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Androgen Deprivation Therapy, Prostate Cancer, Prostate Cancer Metastatic
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A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus
NCT04961567
Recruiting
In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with systemic lupus erythematosus (SLE). The study will focus on participants who have active disease and are already taking standard of care medications. These may include antimalarials, steroids, and immunosuppressants. The main objective of the study is to learn about the effect litifilimab has on lowering the activity of the disease. The main question researchers want to answer is: -... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: Boston University School of Medicine, Boston, Massachusetts
Conditions: Lupus Erythematosus, Systemic
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Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy
NCT04724499
Recruiting
The purpose of this research is to determine whether a 16-week high intensity interval training (HIIT) exercise program will improve brain health among women undergoing chemotherapy and also improve cardiovascular (heart) function. The names of the study interventions involved in this study are/is: * High-Intensity Interval Training (HIIT)
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Breast Cancer, Chemotherapy Effect, Exercise Therapy, Cognitive Change
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Optimizing Family Counseling for Anticipated Extremely Preterm Delivery
NCT03819933
Recruiting
Antenatal family counseling for anticipated extremely preterm deliveries remains ethically and practically challenging for maternal-fetal medicine specialists and neonatologists alike. The overall goal of this project is to improve antenatal counseling and counseling outcomes for families facing anticipated extremely preterm delivery through innovative, interdisciplinary simulation-based education for maternal fetal medicine specialists and neonatologists, using language preferred by families, a... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
01/23/2025
Locations: Boston Children's Hosptial, Boston, Massachusetts
Conditions: Preterm Pregnancy, Premature Birth
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Dendritic Cell/AML Fusion Cell Vaccine Following Allogeneic Transplantation in AML Patients
NCT03679650
Recruiting
This research study is studying a cancer vaccine called Dendritic Cell/AML Fusion vaccine (DC/AML vaccine) as a possible treatment for Acute Myelogenous Leukemia (AML). The interventions involved in this study are: * Dendritic Cell/AML Fusion vaccine (DC/AML vaccine) * Decitabine, a chemotherapy drug
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Acute Myelogenous Leukemia
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Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-type Cyclins or Amplification of CDK4 or CDK6
NCT03310879
Recruiting
This research study is studying a targeted therapy as a possible treatment for cancer abnormality in one of the following genes: CCND1, CCND2, CCND3, CDK4, or CDK6. The drug involved in this study is: -Abemaciclib
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Cancer
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Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the PI3K/mTOR Inhibitor Gedatolisib (PF-05212384) for Patients With Advanced Squamous Cell Lung, Pancreatic, Head & Neck and Other Solid Tumors
NCT03065062
Recruiting
This research study is studying a combination of drugs as a possible treatment for cancer that might have a specific change in the phosphatidylinositol-3 phosphate (PI3K) pathway.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Cancer Squamous Cell, Solid Tumors, Head & Neck Cancer, Pancreatic Cancer
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Embolization Treatment of Chronic Refractory Shoulder Tendinopathy
NCT06095050
Recruiting
This is a randomized controlled trial in which patients with moderate to severe shoulder pain (Visual Analog Scale (VAS) \> 40), in the setting of rotator cuff tendinopathy refractory to conservative treatment, will be enrolled. The primary aim of the study is to estimate the effect of transcatheter arterial embolization (TAE) with physical therapy (PT) vs PT alone on the change in shoulder pain at 12-month follow up. Scientific objectives also include an assessment of safety of the interventio... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
01/22/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Shoulder Pain, Tendinopathy, Rotator Cuff Tendinitis, Rotator Cuff Tendinosis, Embolization, Arterial Occlusion
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Brain Health with Inner Engineering Meditation
NCT05455814
Recruiting
This study will explore whether a 21-minute meditation practice called Shambhavi Mahamudra Kriya leads to changes in brain health and explore how it affects cognitive and physiological function.
Gender:
ALL
Ages:
Between 20 years and 65 years
Trial Updated:
01/22/2025
Locations: Beth Israel Deaconess Medical Centre, Boston, Massachusetts
Conditions: Meditation, Brain; Agenesis
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