Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People At Risk for Alzheimer's Disease
NCT05776641
Recruiting
Alzheimer's disease (AD) is characterized by significant memory loss, toxic protein deposits (amyloid and tau) in the brain, and changes in the gamma frequency band on EEG. Gamma waves are important for memory, and in patients with AD, there are fewer gamma waves in the brain. The Tsai lab found that boosting gamma waves in AD mouse models using light and sound stimulation at 40Hz not only reduced amyloid and tau in the brain, but also improved memory. A light and sound device was developed for... Read More
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
01/08/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Alzheimer Disease, Family Members
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Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients
NCT04773457
Recruiting
Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.
Gender:
ALL
Ages:
Between 12 months and 19 years
Trial Updated:
01/08/2025
Locations: Boston Children's Hopsital, Boston, Massachusetts
Conditions: Surgical Site Infection
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Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery
NCT04299828
Recruiting
The goal of this proposal is to prospectively collect data from a series of 100 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to: 1. Measure the number of blood activated circulating monocytes before, during and after cardiac surgery and serum GABA and pro-inflammatory cytokine levels 2. Understand the correlation between GABA and inflammatory cytokines (and/or activated monocytes) and 3. Assess the correlation between thrombosis and m... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/08/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease, Coagulation
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Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis
NCT04103281
Recruiting
In this research study we want to learn more about the characteristics of neutrophils that are present in the blood and secretions from a breathing tube of patients with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in the lungs in patients with seps... Read More
Gender:
ALL
Ages:
Between 2 years and 50 years
Trial Updated:
01/08/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Sepsis
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Neutrophil Phenotypic Profiling and Organ Injury Assessment in Patients With Sepsis
NCT04103268
Recruiting
In this research study we want to learn more about the character of neutrophils that are present in the blood of children with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in organs in patients with sepsis. Neutrophils can change their character in... Read More
Gender:
ALL
Ages:
Between 1 month and 17 years
Trial Updated:
01/08/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Sepsis
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Gaucher Disease Outcome Survey (GOS)
NCT03291223
Recruiting
The Gaucher Outcomes Survey (GOS) is an ongoing observational, international, multi-center, long-term Registry of Patients with Gaucher Disease irrespective of their treatment status or type of treatment received. No experimental intervention is involved. Patients undergo clinical assessments and receive care as determined by the patients' treating physician. The objectives of the registry include to evaluate the safety and long-term effectiveness of velaglucerase alfa, to characterize patients... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/08/2025
Locations: Central Contact, Lexington, Massachusetts
Conditions: Gaucher Disease
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Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI
NCT06763172
Recruiting
This research study aims to determine whether and how caffeine intake affects learning process through reward feedback compared to placebo. The data acquired from this study would improve our understanding on the consequence and mechanism of caffeine intake in the aspect of learning process. Participants will perform a reinforcement learning task (i.e. Probabilistic Selection Task) and a motor inhibition task (i.e. Go/NoGo task) in a brain scan. The scan will be done with the Siemens Biograph m... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
01/07/2025
Locations: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts
Conditions: Healthy, Caffeine, Adenosine, Dopamine D2/3 Receptor Availability
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Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care
NCT06422689
Recruiting
ANCHOR is a prospective, multi-center, phase IV, interventional, single-arm, open-label study of 2,000 adult participants with symptomatic asthma requiring the use of rescue therapy aimed to compare the asthma exacerbation rates before and after switching from albuterol or levalbuterol to albuterol plus budesonide inhalation aerosol as rescue therapy.
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
01/07/2025
Locations: Research Site, Boston, Massachusetts
Conditions: Asthma
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A Study of D3L-001 as Monotherapy in Subjects With HER2-Positive Advanced Solid Tumors
NCT05957536
Recruiting
This first-in-human (FIH) study, multi-center, open-label, dose escalation and dose expansion Phase I study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and preliminary anti-tumor activity of D3L-001 in subjects with HER2-positive advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: D3 Bio Investigative Site, Boston, Massachusetts
Conditions: HER-2 Positive Advanced Solid Tumors
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A Survey to Assess Participants' and Physicians' Knowledge, Attitudes and Behavior When Using NATPARA
NCT05556629
Recruiting
This main aim of this study is to check the level of knowledge and assess attitudes and behaviors of both participants and prescribing physicians regarding the risks and safe use of NATPARA. The survey will be done via internet, telephone, or paper and participants will be able to choose the method that is preferred. No study medicines will be provided to patients in this study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Shire-NPS Pharmaceuticals, INC. (Shire now part of Takeda), Lexington, Massachusetts
Conditions: Hypoparathyroidism
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Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth In/near Infected Bone Cavities
NCT05361941
Recruiting
This is a pivotal, prospective, multi-center, randomized, concurrent control, patient and assessor-blinded study with two arms: a treatment arm (where subjects will be treated with the EP Granules with Tobramycin investigational device in the 1st stage of a staged revision for periprosthetic joint infection (PJIs), and a control arm (where subjects are treated with the standard-of-care revision for infected PJIs).
Gender:
ALL
Ages:
22 years and above
Trial Updated:
01/07/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Periprosthetic Joint Infections
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Surgical Treatments for Postamputation Pain
NCT05009394
Recruiting
This is a double-blind randomised controlled trial (RCT) which compares the effectiveness of three surgical techniques for alleviating residual limb pain (RLP), neuroma pain and phantom limb pain (PLP). The three surgical treatments are Targeted Muscles Reinnervation (TMR), Regenerative Peripheral Nerve Interface (RPNI), and an active control (neuroma excision and muscle burying). Patients will be follow-up for 4 years.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Amputation Neuroma, Phantom Limb Pain, Pain, Neuropathic, Pain, Nerve, Residual Limb Pain
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