Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)
NCT06322888
Recruiting
The goal of this study is to learn more about how exercise might lower the risk of developing breast cancer in women with dense breast tissue by studying changes that occur in breast tissue and blood as a result of participating in an exercise program. The names of the study groups in this study are: * Exercise Training Group * Waitlist Control Group
Gender:
FEMALE
Ages:
Between 18 years and 59 years
Trial Updated:
12/04/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Breast Cancer, Breast Cancer Female
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Effect of Short-chain Fatty Acids on Aerobic Endurance
NCT06054607
Recruiting
Randomized, double-blind, placebo-controlled crossover study designed to determine the effects of increasing colonic short-chain fatty acid (SCFA) content on aerobic endurance in healthy adults, and to identify underpinning mechanisms. In random order, healthy physically active adults will consume provided diets low in fiber and supplemented with SCFA-enriched high amylose maize starch (a poorly digested resistant starch considered a fermentable fiber) or low amylose maize starch (a rapidly dige... Read More
Gender:
ALL
Ages:
Between 17 years and 39 years
Trial Updated:
12/04/2024
Locations: United States Army Research Institute of Environmental Medicine, Natick, Massachusetts
Conditions: Aerobic Endurance, Metabolism
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MIRAI-MRI: Comparing Screening MRI for Patients at High Risk for Breast Cancer Identified by Mirai and Tyrer-Cuzick
NCT05968157
Recruiting
Accurate risk assessment is essential for the success of population screening programs and early detection efforts in breast cancer. Mirai is a new deep learning model based on full resolution mammograms. Mirai is a mammography-based deep learning model designed to predict risk at multiple timepoints, leverage potentially missing risk factor information, and produce predictions that are consistent across mammography machines. Mirai was trained on a large dataset from Massachusetts General Hospi... Read More
Gender:
FEMALE
Ages:
40 years and above
Trial Updated:
12/04/2024
Locations: UMass Medical School, Worcester, Massachusetts
Conditions: Breast Cancer
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Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies
NCT05476770
Recruiting
Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This trial aims to examine the safety of this novel agent in pediatric patients with relapsed/refractory hematologic malignancies. The mechanism by which tagraxofusp kills cells is distinct from that of conventional chemotherapy. Tagraxofusp directly targets CD123 that is pre... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
12/04/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Hematologic Malignancy, AML, ALL, BPDCN, MDS, Lymphoblastic Lymphoma, Lymphoma, B-Cell, Lymphoma, T-Cell, Hodgkin Lymphoma, Mixed Phenotype Acute Leukemia, Acute Undifferentiated Leukemia
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Investigating Exercise in Myotonic Dystrophy Type 2 (DM2)
NCT06716931
Recruiting
An exercise regimen (PRIME: Proximal Resistance In-House Movement Exercise) has been designed for patients with myotonic dystrophy type 2 (DM2). The hypothesis is that this patient-friendly physical therapist (PT)-guided exercise program associates with improved functional capacity and muscle composition in DM2 in this two-period two-sequence cross-over study. Thus, participant will be randomized to one of the three possible groups. Participants in GROUP A will perform exercise routine in clinic... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/03/2024
Locations: Neuromuscular Diagnostic Center. Massachusetts General Hospital, Boston, Massachusetts
Conditions: Myotonic Dystrophy 2
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A Multi-Site Leukopak Repository Providing Annotated Biospecimens for Approved Investigator-Directed Biomedical Research Initiatives
NCT05794217
Recruiting
To collect, preserve, and distribute annotated leukopak biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and preventative methods for specific and complex conditions. This protocol will be utilized to collect research grade products that are not meant for transfusion.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
12/03/2024
Locations: Sanguine Biosciences, Waltham, Massachusetts
Conditions: Rare Diseases
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Enhancing Information Management for Young Adults After Genetic Cancer Risk Testing
NCT05759143
Recruiting
This research is being done to develop the electronic platform Nest for young adults (ages 18-39) who have had prior cancer genetic testing. The platform will give patients and their clinicians access to continuously updated information about both pathogenic variants and variants of uncertain significance (VUS). The name of the intervention used in this research study is: Nest portal (electronic platform for patients and clinicians)
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
12/03/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Genetic Predisposition to Disease, Genetic Predisposition
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A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer
NCT05710848
Recruiting
This is a first-in-human (FIH), Phase 1/2a, multi center, open-label, single treatment, dose escalation and expansion study designed to determine the safety and tolerability of STM-416 in patients with bladder cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Non-muscle-invasive Bladder Cancer
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Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients
NCT05699603
Recruiting
This phase IIA study evaluates the effects of calcipotriene plus 5- fluorouracil immunotherapy for skin cancer prevention in organ transplant recipients. Solid organ transplant recipients are at high risk of developing skin cancer. Actinic keratosis (AK), is a premalignant skin lesion that can progress to squamous cell skin cancer. In this study, solid organ transplant recipients with multiple AKs are treated with topical calcipotriene and 5-FU to evaluate how effective this therapy is against A... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Actinic Keratosis
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A Survey to Assess Participants' and Physicians' Knowledge, Attitudes and Behavior When Using GATTEX
NCT05561647
Recruiting
The main aim of this study is to document the level of knowledge and assess attitudes and behaviors of both participants and physicians regarding the risks and safe use of GATTEX. The survey will be done via internet, telephone, or paper and both physicians and participants will be able to choose the method that is preferred. No study medicines will be provided to participants in this study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Shire-NPS Pharmaceuticals, INC., Lexington, Massachusetts
Conditions: Short Bowel Syndrome (SBS)
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Studying the Neuronal Basis of Human Social Cognition
NCT05324579
Recruiting
This proposal aims to study the role that the dorsal prefrontal cortex plays in human social cognition.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Neurosciences
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Treating Hyperexcitability in AD With Levetiracetam
NCT03875638
Recruiting
The aim of this study is to explore the relationship between cortical hyperexcitability, abnormalities of brain network function, and cognitive dysfunction in human patients with AD and whether administration of the antiepileptic medication levetiracetam (LEV) normalizes these measures and improves cognition.
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
12/03/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Alzheimer Dementia, Alzheimer Disease, Dementia of Alzheimer Type, Mild Cognitive Impairment
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