Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Promoting Improved Functioning Among People Experiencing Stressful Situations
NCT06482567
Recruiting
The iCOVER intervention was developed to rapidly restore functioning in individuals experiencing an Acute Stress Reaction (ASR). iCOVER is undergoing widespread adoption but has not been tested for efficacy. iCOVER was designed to be administered by peers, paraprofessionals, or medical personnel in 60-120 seconds, including in military operational environments. The term iCOVER is an acronym that summarizes the six specific steps of the intervention: (1) identify that an individual is experiencin... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
12/02/2024
Locations: McLean Hospital, Harvard Medical School, Belmont, Massachusetts
Conditions: Acute Stress Reaction
Register for Updates
Effectiveness of Cognitive Training in Older and Younger Adults
NCT06375681
Recruiting
The proposed study will enroll 1600 participants to examine the effectiveness of cognitive training. Participants will be randomized into different experimental groups and can expect to participate for up to 15 hours of research over 4 to 8 weeks.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
12/02/2024
Locations: Northeastern University, Boston, Massachusetts
Conditions: Cognitive Change
Register for Updates
Mechanisms of Anabolic Osteoporosis Therapy
NCT05688969
Recruiting
The aim of this study is to investigate the effect of romosozumab on bone cells during early and late phases of treatment.
Gender:
FEMALE
Ages:
45 years and above
Trial Updated:
12/02/2024
Locations: Mass General Brigham, Boston, Massachusetts
Conditions: Osteoporosis, Postmenopausal
Register for Updates
IS-free Treg HaploHCT
NCT04678401
Recruiting
This research study is evaluating the safety and efficacy of the IS-free Treg-cell graft-engineered haplo transplant method in people with relapsed/refractory and Ultra-high risk acute myeloid leukemia (AML) and/or myelodysplastic syndromes (MDS) receiving a haploidentical donor allogeneic hematopoietic stem cell transplant (HSCT). The names of the study interventions involved in this study are: * Radiation-Total Myeloid and Lymphoid Irradiation (TMLI * Chemotherapy (Fludarabine, Thiotepa, Cyc... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/02/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Stem Cell Transplant Complications, Graft Vs Host Disease, Myeloid Leukemia, Acute, Myeloid Leukemia in Relapse (Disorder), Myelodysplastic Syndromes
Register for Updates
Phase 1 Trial of ZM008 as Single Agent and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors
NCT06451497
Recruiting
This is a phase 1 dose escalation trial of ZM008, an anti-LLT1 antibody as a single agent followed by combination with Pembrolizumab in patients with advanced solid tumors who have exhausted all standard therapy available or are intolerant of the same.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/29/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Non Small Cell Lung Cancer, Esophageal Cancer, Head and Neck Squamous Cell Carcinoma, Pancreas Adenocarcinoma, Biliary Tract Cancer, Prostate Cancer, Urothelial Carcinoma, Colorectal Cancer, Triple Negative Breast Cancer, High Grade Ovarian Serous Adenocarcinoma, Diffuse Large B Cell Lymphoma
Register for Updates
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)
NCT06511934
Recruiting
People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert. In this project, the investigators seek to further translate knowledge about interpreting brain signals related to movement, and to further develop an intracortical brain-computer interface (iBCI) that could restore rapid and intuitive use of communication apps on tablet computers by people with paraly... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/27/2024
Locations: Masssachusetts General Hospital, Boston, Massachusetts
Conditions: Brainstem Stroke, ALS, Tetraplegia, Spinal Cord Injuries, Cervical Spinal Cord Injury
Register for Updates
Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population
NCT05799222
Recruiting
This study is being done to better understand whether meal replacements can be an effective tool for weight loss and treatment of elevated blood sugars in people with obesity/overweight and diabetes/pre-diabetes who have a low income.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/27/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Overweight, PreDiabetes, Diabetes Type 2, Obesity
Register for Updates
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
NCT05724173
Recruiting
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/27/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked in Syndrome, Muscular Dystrophies
Register for Updates
Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD
NCT05438732
Recruiting
The objective of this study is to determine the safety and effectiveness of the smaller incision, new generation (SING), implantable miniature telescope (IMT) in patients with moderate-severe central vision loss due to late-stage age-related macular degeneration (AMD).
Gender:
ALL
Ages:
65 years and above
Trial Updated:
11/27/2024
Locations: Tallman Eye Associates, Lawrence, Massachusetts
Conditions: Age-Related Macular Degeneration, Geographic Atrophy
Register for Updates
Cardiac Sarcoidosis Randomized Trial
NCT03593759
Recruiting
Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active clinically manifest cardiac sarcoidosis and not yet treated. The Investigators hypothesize that low dose Prednisone(or Prednisolone)/Methotrexate combination will be as effective as standard dose Prednisone(or Prednisolone), and result in significantly better quality of life and less toxicity than sta... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Cardiac Sarcoidosis, Sarcoidosis
Register for Updates
Molecular and Genetic Analysis of Lung Cancer
NCT03029325
Recruiting
Investigators use a genome-wide approach within a case-control design to identify SNPs that show evidence of association with lung cancer risk and survival.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Cancer
Register for Updates
DNA Analysis of Blood and Tissue from Patients with Lung Cancer
NCT00471978
Recruiting
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This clinical trial is analyzing the DNA in blood and tissue samples from patients with lung cancer.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
11/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Cancer
Register for Updates