Massachusetts is currently home to 3152 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Sensor-based Just-in Time Adaptive Interventions (JITAIs) Targeting Eating Behavior
NCT06547320
Recruiting
The purpose of this study is to determine whether a sensor device called an Automatic Ingestion Monitor (AIM) that is worn on eyeglasses can be used with a smartphone to change eating behavior. Participants will wear the device for one week of no-intervention observation. They will then test behavioral interventions focused on eating for two weeks. The researchers hypothesize that messages sent to a smartphone that are based on information from the AIM can reduce the amount of food that is eaten... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/07/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Overweight and Obesity
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Improving Virtual Care of Arthritis: Integrating a Smartphone App Into the EHR for Improved Timeliness of Visits
NCT06004700
Recruiting
The overall objective of this proposal is to test version 3.0 of the Arthritis smartphone app in a 12-month interrupted time series analysis (ITSA) design which will allow us to observe possible differences in visit frequency between the pre-and post-intervention periods as well as between the concurrent control group and those who receive the app. Our central hypothesis is that introduction of the app will reduce visit numbers per month in the group receiving the app, compared with a concurrent... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Arthritis, Psoriatic Arthritis
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AWARE: Management of ADHD in Autism Spectrum Disorder
NCT05916339
Recruiting
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism. Using a sequential, multiple assignment randomization trial (SMART) design the study will not only assess these two medications but also the role of an increasingly popular class of ADHD medication, the alpha-2 agonists. Findings from this study will help improve clinicians' approach to me... Read More
Gender:
ALL
Ages:
Between 4 years and 17 years
Trial Updated:
08/07/2024
Locations: Massachusetts General Hospital Lurie Center for Autism, Boston, Massachusetts
Conditions: ADHD, Autism Spectrum Disorder
Register for Updates
Menstrual-phase-dependent Differences in Response to Sleep Loss
NCT05381532
Recruiting
This study is designed to assess how healthy premenopausal women respond to different patterns of sleep loss at different times in the menstrual cycle.
Gender:
FEMALE
Ages:
Between 18 years and 35 years
Trial Updated:
08/07/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Sleep Deprivation
Register for Updates
A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment
NCT05189223
Recruiting
The US Veteran community continues to feel the impact of the overdose crisis, and opioid use disorder (OUD) diagnoses among Veterans continue to rise. Medication treatment (e.g., buprenorphine, methadone, naltrexone) helps prevent relapse and reduce overdose risk, but does not help with the psychological, social, and functional challenges of early recovery. Therapies that focus on interpersonal functioning and community integration may help improve quality of life during this high-risk period. T... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: VA Bedford HealthCare System, Bedford, MA, Bedford, Massachusetts
Conditions: Dependence, Opioid
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The Impact of Pcsk-9 Inhibition on PET CFR in Patients at High CV Risk
NCT05152888
Recruiting
The study protocol is a single-arm, open label pilot study designed to evaluate the impact of PCSK-9 inhibition on coronary blood flow in patients with stable coronary artery disease. Patients with stable coronary artery disease will be recruited from the BWH Cardiovascular Medicine clinic and/or from the BWH Nuclear Cardiology Laboratory. A target sample size of 50 participants will undergo imaging with N-13 ammonia or Rubidium-82 positron emission tomography (PET) and coronary computed tomogra... Read More
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
08/07/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Stable Coronary Disease
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TCF-001 TRACK (Target Rare Cancer Knowledge) Study
NCT04504604
Recruiting
This open label, non-randomized, multi-center, pragmatic study aims to establish whether patients with rare tumors can benefit from matched molecular therapy as dictated by their next-generation sequencing (NGS) results.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: TargetCancer Foundation, Cambridge, Massachusetts
Conditions: Rare Cancers, Cholangiocarcinoma, Cancer of Unknown Primary Site
Register for Updates
The Physiology of Human Brown Adipose Tissue
NCT04352244
Recruiting
Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories. Understanding more about differences between brown and white fat may allow us to develop new approaches to improve the body's metabolism.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/07/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Adipose Tissue, Brown, Adipose Tissue, Obesity
Register for Updates
High Intensity Focused Electromagnetic Field Device for Urinary Incontinence
NCT04031014
Recruiting
High intensity focused electromagnetic (HIFEM) technology induces deep pelvic floor muscle contractions designed to deliver the equivalent of 11,200 Kegel exercise over 28 minutes, with the intention of increasing neuromuscular tone of the pelvic floor. This study will have looking at treatment of the two of the most common pelvic floor disorders: stress or stress predominant urinary incontinence and urge or urge predominant urinary incontinence.
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
08/07/2024
Locations: Boston Urogynecology Associates, Cambridge, Massachusetts
Conditions: Stress Urinary Incontinence, Urge Incontinence, Urge and Stress, Overactive Bladder
Register for Updates
Neuromodulation for a Novel OCD Biomarker and Treatment
NCT05994053
Recruiting
Although multiple treatments for OCD exist, slow symptom decrease, high remission, and significant side effects for some OCD patients limit their efficacy. More research into the precise neural mechanisms and linked cognitive functions in OCD is also necessary. To address both concerns, this study by Dr. Reinhart and his team will test a new, non-invasive, and well-tolerated neuromodulation method for reducing OCD symptoms, based on reward-related rhythms of the orbitofrontal cortex (OFC; a brai... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: Boston University Center for Anxiety and Related Disorders (BU-CARD), Boston, Massachusetts
Conditions: OCD
Register for Updates
Hydrogen's Feasibility and Safety as a Therapy in ECPR
NCT05574296
Recruiting
The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e. mechanical circulatory support). Under exemption from informed consent, patients undergoing refractory cardiac arrest in the cardiac ICU at a participating center will be randomized to standard therapy with or without the administration of 2% hydrogen in gases administered via the... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/06/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Cardiac Arrest, Extracorporeal Membrane Oxygenation, Reperfusion Injury
Register for Updates
ABTECT - Maintenance
NCT05535946
Recruiting
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhi... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/06/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Ulcerative Colitis
Register for Updates