Massachusetts is currently home to 3147 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Intermittent Fasting for NAFLD in Adults
NCT04899102
Recruiting
NAFLD is a growing threat to public health. Currently, there is a significant need for highly effective treatments for NAFLD. Non-obese NAFLD (BMI\<30kg/m2) is an increasingly recognized condition, sometimes described as "lean NAFLD". Intermittent Fasting (IF) may be uniquely beneficial in non-obese NAFLD. The purpose of this study is to identify non-pharmacologic, lifestyle-based methods of NAFLD treatment within non-obese adults.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Fatty Liver, Intermittent Fasting, Fatty Liver, Nonalcoholic, Non-Alcoholic Fatty Liver Disease, Liver Fat
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MBG453 in Lower Risk MDS
NCT04823624
Recruiting
This research study is assessing the efficacy of MBG-453, a humanized monoclonal antibody, in treating myelodysplastic syndromes (MDS). The name of the study drug involved in this study is MBG453.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Myelodysplastic Syndromes
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Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD
NCT04759703
Recruiting
The investigators propose to test the use of pramipexole in patients being treated for Opioid Use Disorder to test its ability to reduce symptoms of both Restless Legs Syndrome and protracted opioid withdrawal and thereby promote initiation, engagement, and retention in treatment.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Sleep Disorder, Restless Legs Syndrome, Opioid-use Disorder, Opioid Withdrawal
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Calcitriol Monotherapy for X-Linked Hypophosphatemia
NCT03748966
Recruiting
Children and adults with XLH recruited will be treated with calcitriol alone (without phosphate supplementation) for one year, during which the calcitriol dose will be escalated during the first 3 months of therapy. The investigators hypothesize that treatment of adults and children with XLH alone will improve serum phosphate levels and skeletal mineralization without causing an increase in kidney calcifications. The study will also examine if calcitriol therapy will improve growth in children.
Gender:
ALL
Ages:
Between 3 years and 70 years
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: X-linked Hypophosphatemia, Hypophosphatemic Rickets, Hypophosphatemic Rickets, X-Linked Dominant
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A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
NCT02118922
Recruiting
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties of post-LASIK ectasia vs. normal corneas.
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Keratoconus, Ectasia, Crosslinking, Fuchs' Endothelial Dystrophy
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Speech Treatment for Minimally Verbal Children With ASD and CAS
NCT05066178
Recruiting
Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning. This study tests whether CAS-specific treatment, appropriately modified for minimally verbal children with autism, improves their speech.
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
03/10/2024
Locations: MGH Institute of Health Professions, Boston, Massachusetts
Conditions: Developmental Verbal Dyspraxia, Autism Spectrum Disorder
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MRI Guided Prostate Biopsy
NCT06302595
Recruiting
This study aims to assess the feasibility of magnetic resonance (MR) guided prostate biopsy using a needle holder frame. This frame is used to help position the needle used for the biopsy. The feasibility in this study is defined as whether the needle holder frame enables accurate tissue sampling from a suspicious region in the prostate found on an MR image. If it does, a biopsy can be carried out with the needle holder frame safely in a clinical routine. The study will be conducted during a rou... Read More
Gender:
MALE
Ages:
30 years and above
Trial Updated:
03/08/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Suspected Prostate Cancer
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Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy
NCT06300450
Recruiting
This single-center, 400-patient, randomized controlled trial assesses the impact of a patient- and provider-facing EPIC Best Practice Advisory (BPA; alert-based computerized decision support tool) to increase guideline-directed utilization of statin and statin-alternative oral LDL-C lowering therapies in patients with PAD who are not being prescribed LDL-C-lowering therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Peripheral Artery Disease, Peripheral Vascular Diseases, Dyslipidemias
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Emergency Care at Home
NCT06299774
Recruiting
This study will assess the efficacy of receiving emergency care at home versus in the brick-and-mortar emergency department.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Emergency Medical Services, Emergency Department Visits
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Inqovi Maintenance Therapy in Myeloid Neoplasms
NCT04980404
Recruiting
This research is being done to see if the drug Inqov is effective in reducing the chance of myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) relapsing after standard of care stem cell transplant. * This research study involves the study drug Inqovi, which is a combination of the drugs decitabine and cedazuridine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, Stem Cell Leukemia
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Resilience and Equity in Aging, Cancer, and Health (REACH)
NCT04674267
Recruiting
The purpose of this multi-phase research study is to understand how consultation of cancer care with a geriatrician can best improve outcomes for older adults with gastrointestinal malignancies.
Gender:
ALL
Ages:
70 years and above
Trial Updated:
03/06/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Gastric Cancer, Colon Cancer, Esophageal Cancer, Rectal Cancer, Pancreatic Cancer, Gastrointestinal Cancer
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Ruxolitinib in Thrombocythemia and Polycythemia Vera
NCT04644211
Recruiting
This research is being done to see if the drug ruxolitinib is effective in reducing the symptoms caused by low-risk essential thrombocythemia (ET) and polycythemia vera (PV). - This research study involves the study drug Ruxolitinib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Essential Thrombocythemia, Polycythemia Vera
Register for Updates