Massachusetts is currently home to 3175 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Epidermal Skin Grafts to Improve Healing In Radiation Wounds
NCT04560803
Recruiting
Patients undergoing radiation for the treatment of malignancies may suffer from side effects to the skin in the form of radiation dermatitis. This can lead to local wound formation with poor healing. Treatment options for the resulting wound can range from watchful waiting to more aggressive debridement and secondary grafting. Epidermal grafting is a technique in which autologous epidermis is used to cover wounds that are larger than the donor site. Previous studies have demonstrated that this... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/20/2023
Locations: Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts
Conditions: Radiation Dermatitis
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A Study of HB0045 Injection in Patients With Advanced Solid Tumors
NCT06056323
Recruiting
This is a phase I/II, open-label, multicenter study . During the study, subjects will be evaluated for safety, toxicity, tolerability, PK/PD, immunogenicity, biomarkers, and antitumor activity of HB0045. The phase I study will enroll up to 54 subjects with advanced solid tumors who have progressed on or after standard of care therapy and for whom there is no further treatment available that in the judgement of the patient's physician would be beneficial. One cycle is defined as 21 days.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Solid Tumor, Adult
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Triage Survey for Psychiatry Research Eligibility
NCT05800925
Recruiting
TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: Copley Clinical, Boston, Massachusetts
Conditions: Major Depressive Disorder, Borderline Personality Disorder, Generalized Anxiety Disorder
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IlluminOss Photodynamic Bone Stabilization System for the Treatment of Impending and Actual Pelvis Fractures
NCT04842266
Recruiting
The aim of this project is to assess the effectiveness of the IlluminOss pelvic implants in patients with pelvic metastatic disease presenting with pain, risk of pathologic fracture, non-displaced or minimally displaced pathologic fracture of the pelvis, and geriatric patients with pelvic fragility fractures. Results from this study will be used to confirm preliminary clinically and possibly statistically significant reductions in pain and improvements in function among these patients.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/19/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Cancer Metastatic, Trauma, Pathologic Fracture
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Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome
NCT05528744
Recruiting
The purpose of this study is to establish a registry of individuals with confirmed or suspected Chopra-Amiel-Gordon Syndrome (CAGS) to learn more about the range of symptoms, changes in the structure of the brain seen on imaging, and learning difficulties that individuals with this disorder may experience. The investigators will obtain medical history, family history, MRI records, patient photographs, and genetic test results from individuals with confirmed or suspected CAGS. A subset of partici... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/18/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Genetic Disease, Chopra-Amiel-Gordon Syndrome, CAGS, ANKRD17
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Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain
NCT04488757
Recruiting
Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients' suffering, making it a critical area of empirical investigation.
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
10/18/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Chronic Widespread Pain, Stress, Psychological, Stress, Physiological
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Supplemental Oxygen in Pulmonary Embolism (SO-PE)
NCT05891886
Recruiting
A study of how supplemental oxygen helps patients with acute pulmonary embolism (PE). Hypothesis: Oxygen affects right ventricular dysfunction (RVD) in patients with acute pulmonary embolism (PE) primarily by relieving hypoxic pulmonary vasoconstriction and reducing pulmonary pressure (PA) pressure, and that this process is metabolically driven.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/17/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pulmonary Embolism, Venous Thromboembolism, Metabolomics, Oxygen Inhalation Therapy
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Care Planning for a Loved One With Dementia: Knowledge, Preparing for Decisions, and Emotions
NCT05165186
Recruiting
The overall objective of this study is to compare knowledge, decisional conflict, preferences, and caregiver burden over time caregivers of Alzheimer's Disease and Related Dementias (ADRD) patients by comparing the effectiveness of a video decision aid intervention and enhanced usual care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/17/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Dementia, Dementia Frontotemporal, Dementia Alzheimers, Dementia, Mild, Dementia Moderate, Dementia Severe, Caregiver Burnout, Caregiver Stress Syndrome
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Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
NCT04940663
Recruiting
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutic... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
10/17/2023
Locations: Massachusetts General Hospital, Charlestown, Massachusetts
Conditions: Psychosis, Schizophrenia
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VE416 for Treatment of Food Allergy
NCT03936998
Recruiting
This is a single-center, randomized, double-blind trial with four arms evaluating VE416 as pretreatment or concurrent treatment in comparison to low-dose peanut oral immunotherapy (PNOIT) alone.
Gender:
ALL
Ages:
Between 12 years and 55 years
Trial Updated:
10/17/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Peanut Allergy
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Identifying Sleep Apnea Patients That Best Respond to Atomoxetine Plus Oxybutynin Therapy
NCT05550246
Recruiting
Atomoxetine-plus-oxybutynin therapy (AtoOxy) has been shown to substantially reduce obstructive sleep apnea severity (OSA) in about half of patients. Here, the investigators will study which patients respond meaningfully to therapy using pathophysiological traits measured at baseline sleep studies.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
10/16/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
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Responders to Rhythmic Auditory Stimulation in Individuals Post-Stroke and Older Adults
NCT06085248
Recruiting
Stroke is among the leading causes of long-term disability worldwide. Post-stroke neuromotor impairments are heterogeneous, yet often result in reduced walking ability characterized by slow, asymmetric, and unstable gait patterns. Rhythmic Auditory Stimulation (RAS) is an emerging rehabilitation approach that leverages auditory-motor synchronization to retrain neuromotor control of walking. Indeed, walking with RAS can enhance walking rhythmicity, gait quality, and speed. RAS is a potentially va... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/13/2023
Locations: Boston University Neuromotor Recovery Laboratory, Boston, Massachusetts
Conditions: Stroke, Old Age
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