Massachusetts is currently home to 3175 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy
NCT01696721
Recruiting
In previous studies, Proton Beam Radiation Therapy (PBRT) has been found to show better results in treating patients with cancer, both because there is better control of where in the body the radiation is directed and because it is associated with less severe long term side effects. However, there is limited published data demonstrating these results. The goal of the Proton and Photon Consortium Registry (PPCR) is to enroll children treated with radiation in order to describe the population that... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
01/05/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pediatric Patients Treated With Radiation Therapy
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Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury
NCT04458324
Recruiting
Over the past ten years, the Cardiovascular Research Laboratory at Spaulding has refined a unique form of exercise for those with spinal cord injuries (SCI). Functional Electrical Stimulation Row Training (FESRT) couples volitional arm and electrically controlled leg exercise, resulting in the benefits of large muscle mass exercise. However, despite the potential for enhancing aerobic capacity by training the denervated leg skeletal muscle via hybrid FES exercise, the inability to increase venti... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
01/03/2023
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Spinal Cord Injuries
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Investigation of Anatomical Correlates of Speech Discrimination
NCT01781039
Recruiting
Understanding speech is essential for good communication. Individuals with hearing loss and poor speech discrimination often have little success with hearing aids because amplifying sound improves audibility, but not clarity of the speech signal. The purpose of this study is to determine the relative importance of the sensory cells of the inner ear and auditory neurons on speech discrimination performance in quiet and in noise. This information may be used as a predictor of hearing aid benefit.... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
12/23/2022
Locations: Steward St. Elizabeth's Medical Center, Brighton, Massachusetts
Conditions: Sensorineural Hearing Loss
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RCT Study to Validate niPGT-A Clinical Benefit.
NCT04000152
Recruiting
Chromosomal aneuploidies are linked with spontaneous miscarriages and abnormal offspring in human pregnancies. In addition, some types of aneuploidies are reported to prevent implantation. Thus, there is a need to identify the embryos with highest implantation potential on in vitro fertilization (IVF) programs. Since embryo morphology and kinetics have a weak association with embryo ploidy, trophectoderm biopsy plus Next-Generation Sequencing (NGS) is becoming a very popular approach to determi... Read More
Gender:
FEMALE
Ages:
Between 20 years and 40 years
Trial Updated:
12/13/2022
Locations: Boston IVF Fertility Clinic, Boston, Massachusetts
Conditions: Aneuploidy, Chromosome Abnormality, Infertility
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First in Human Phase 1 Ascending Dose Study of PanChol in Healthy Volunteers
NCT05657782
Recruiting
This study is a first-in-human, Phase 1 study of the safety, tolerability, and immunogenicity of PanChol in healthy volunteers. There will be three modules in this clinical trial assessing dosing, safety, and immunogenicity: 1. a fixed dose-ranging module, 2. an adaptive dose-finding/optimization module, and 3. a placebo-controlled expansion module.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
12/11/2022
Locations: Brigham and Women's Hospital Vaccine Unit, Boston, Massachusetts
Conditions: Cholera, Cholera Vaccine Toxicity
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Computer-based Training of Face Recollection to Improve Face Recognition in Developmental Prosopagnosia
NCT04799340
Recruiting
This study will examine the effectiveness of a cognitive training intervention targeting face recollection, repetition lag training, at improving face recognition in Developmental Prosopagnosia.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/23/2022
Locations: VA Boston Healthcare System, 150 S. Huntington Ave., Boston, Massachusetts
Conditions: Developmental Prosopagnosia
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Improving Spatial Perception and Speech Understanding in Multitalker Mixtures
NCT05260307
Recruiting
The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. The hypotheses are that spatial perception and speech intelligibility will be improved by (1) increased high-frequency audibility, (2) speech envelope enhancement, and/or (3) appropriate sound image externalization.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/16/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Hearing Loss
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Study on Allopregnanolone and Depression in Perimenopausal Women
NCT05329779
Recruiting
This study aims to identify how the progesterone metabolite allopregnanolone affects behavior and neurobiology that may underlie perimenopausal depression.
Gender:
FEMALE
Ages:
Between 40 years and 60 years
Trial Updated:
11/08/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Depression
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Collection and Distribution of Biospecimens for Novel Research Uses
NCT03848962
Recruiting
iSpecimen aims to create a clinical partner network of hospitals, laboratories, academic institutions, and other healthcare organizations ("institutions") capable of providing researchers and educators ("researchers") with annotated biospecimens for use in biomarker discovery and validation; diagnostic test and instrumentation development and validation; therapeutics development; other medical research including the impact that various specimen collection and handling methods and conditions have... Read More
Gender:
ALL
Ages:
Between 1 month and 89 years
Trial Updated:
11/08/2022
Locations: iSpecimen, Lexington, Massachusetts
Conditions: Cancer, Healthy, Gastrointestinal Complication, Autoimmune Diseases, Infectious Disease, Women's Health: High-Risk Pregnancy, Dermatologic Disease, Blood Disease
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MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
NCT02075775
Recruiting
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiogra... Read More
Gender:
ALL
Ages:
Between 12 years and 99 years
Trial Updated:
11/07/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Other Instability, Shoulder, Dislocations, Subluxations, Recurrent Dislocation of Shoulder Region
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Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic Nerve
NCT05605951
Recruiting
The goal of this observational study is to longitudinally investigating subjects with inaugural acute optic neuritis (ON). The main questions it aims to answer are: * Does the time to corticosteroid treatment affect the visual outcome at 6 months in subjects with acute multiple sclerosis (MS)-, aquaporin 4-IgG positive (AQP4-IgG+) and myelin-oligodendrocyte-glycoprotein-IgG positive (MOG-IgG+) ON? * How differ clinical, structural, and laboratory biomarkers in subjects with acute ON, including... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2022
Locations: Harvard Medical School, Boston, Massachusetts
Conditions: Demyelinating Diseases, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder Attack, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Optic Neuritis
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Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation
NCT05351333
Recruiting
The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury. The goal is to provide the same level of pain relief with a reduced opioid intake to diminish side effects as well as the risk of addiction associated with opioid treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2022
Locations: Spaulding Rehabilitation Hospital, Charlestown, Massachusetts
Conditions: Spinal Cord Injuries, Polytrauma, Burns
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