Massachusetts is currently home to 3138 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Neural Correlates of Stress and Perceived Control in Adolescent Depression
NCT04788524
Recruiting
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechan... Read More
Gender:
FEMALE
Ages:
Between 14 years and 18 years
Trial Updated:
04/21/2022
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Major Depressive Disorder
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Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD)
NCT03540771
Recruiting
This is a comparative effectiveness study of two pragmatic models aiming to introduce palliative care for end stage liver disease patients. The 2 comparators are: Model 1: Consultative Palliative Care (i.e. direct access to Palliative Care provider), Model 2: Trained Hepatologist- led PC intervention (i.e. a hepatologist will receive formal training to deliver Palliative Care services) Primary Outcome: The change in quality of life from baseline to 3 months post enrollment as assessed by FACT-... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
04/05/2022
Locations: VA Boston, Boston, Massachusetts
Conditions: End Stage Liver Disease
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Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The DETECT AS Trial
NCT05230225
Recruiting
The DETECT AS Trial is a randomized clinical trial and quality improvement initiative that seeks to investigate the impact of electronic provider notification of severe aortic stenosis (AS) on its management, on the utilization of aortic valve replacement (AVR), and on ethnic and racial disparities in AVR utilization. After the investigators identify patients in whom echocardiography shows severe aortic stenosis, defined by an aortic valve area (AVA) \<1.0cm2, the ordering provider of the echoc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Aortic Stenosis
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Parents Advancing Toddler Health
NCT04824989
Recruiting
Although early interventions can improve health equity in young children living in poverty, this promise often is not realized because of barriers to family engagement. The proposed study will target co-morbid behavior and sleep problems in early childhood, comparing child outcomes and family response to sleep and behavior interventions and investigating the novel strategy of letting families select their intervention.We will enroll 500 low-income toddlers with co-morbid sleep and behavior probl... Read More
Gender:
ALL
Ages:
Between 18 months and 48 months
Trial Updated:
04/01/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Sleep Problem, Behavior, Child
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Non Exudative AMD Imaged With SS-OCT- Extension
NCT04469140
Recruiting
The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.
Gender:
ALL
Ages:
All
Trial Updated:
03/08/2022
Locations: New England Eye Center/Tufts Medical Center, Boston, Massachusetts
Conditions: Dry Macular Degeneration
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Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
NCT05211856
Recruiting
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
01/14/2022
Locations: Research Site, Boston, Massachusetts
Conditions: Chronic Lymphocytic Leukemia
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FDG an Myocardial Infarction: The PIAF Trial
NCT05138718
Recruiting
In order to define distinct and reliable arterial 18Fluorodeoxyglucose (FDG) thresholds identifying patients at risk for cardiovascular events, patients with a history of myocardial infarction will be included in this international multicenter trial. Non-enhanced whole-body FDG PET/CT will be performed in all patients and the arterial FDG uptake in the carotid arteries as well as the aorta will be quantified by calculating different uptake parameters. In addition, FDG uptake in hematopoietic tis... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/30/2021
Locations: Massachusetts General Hospital, Havard Medical School, Boston, Massachusetts
Conditions: History of Myocardial Infarction
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LEAD IT! An App to Enable Persons With Early Stage Dementia to Lead Group Activities for Their Peers
NCT04899973
Recruiting
The proposed Phase 2 project will involve the further development and evaluation of LEAD IT!, which is a tablet-based app designed to enable persons with dementia to lead activities for their peers (i.e., other persons with dementia). The study will examine the clinical outcomes of long-term use of the app by both Resident Leaders (RLs) and Resident Players (RPs). The Specific Aims of the proposed Phase 2 project are to: Develop improved Beta 1 and Beta 2 Versions of LEAD IT! with sufficient c... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2021
Locations: Hearthstone Alzheimer Care, Winchester, Massachusetts
Conditions: Dementia, Alzheimer Disease
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The HALT Biomarker Study
NCT04552275
Recruiting
The purpose of the HALT Biomarkers study are to identify a panel of circulating proteins that discriminates between patients with and without Hypo-Attenuated Leaflet Thickening (HALT) and can be used to supplement the diagnosis of HALT; to characterize changes in circulating proteins after treatment of HALT with systemic anticoagulation; and to identify circulating proteins that predict the occurrence of HALT. The study population will be adult patients undergoing transfemoral transcatheter aor... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
11/02/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Aortic Stenosis, Hypo-attenuated Leaflet Thickening, Bioprosthetic Valve Degeneration
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Management of Esophagitis Following Repair of Esophageal Atresia
NCT03619408
Recruiting
The goal of this study is to prospectively evaluate the impact of antacid therapy on esophagitis in children with repaired esophageal atresia. Recent clinical guidelines have attempted to define a systematic approach to the management of these patients with regards to minimizing and treating esophagitis (Krishnan et al 2016), however the quality of evidence supporting many of the recommendations are based on expert opinion or on limited, retrospective studies. Risk factors for esophagitis and op... Read More
Gender:
ALL
Ages:
Between 30 days and 17 years
Trial Updated:
09/02/2021
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Esophageal Atresia, Esophagitis
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The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL
NCT03509961
Recruiting
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regime... Read More
Gender:
ALL
Ages:
Between 1 year and 25 years
Trial Updated:
08/20/2021
Locations: Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts
Conditions: B-cell Acute Lymphoblastic Leukemia
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9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis
NCT04510220
Recruiting
We aim to assess the effect of Ofatumumab on microglial activation using \[F-18\]PBR06 PET in MS patients in relation to changes in serum markers, MRI abnormalities and clinical impairment longitudinally over 9 months. Specific Aims: Specific Aim 1: To determine the effect of Ofatumumab on microglial activation in MS over 9 months. Specific Aim 2: To determine the time course of effect of Ofatumumab on microglial activation and its relationship with peripheral B-cell depletion, serum neurofil... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/20/2021
Locations: Partners MS Center, 60 Fenwood Road, Boston, Massachusetts
Conditions: Relapsing Multiple Sclerosis
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