Colorado is currently home to 1917 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)
Recruiting
This study will evaluate the safety of BXQ-350 and determine the maximum tolerated dose (MTD) in children with newly diagnosed DIPG or DMG. All patients will receive BXQ-350 by intravenous (IV) infusion and radiation therapy. The study is divided into two parts: Part 1 will enroll patients at increasing dose levels of BXQ-350 in order to determine the MTD. Part 2 will enroll patients requiring a biopsy in order to assess BXQ-350 concentrations in the biopsied tumor.
Gender:
All
Ages:
Between 1 year and 30 years
Trial Updated:
05/23/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
Adjustable Continence Therapy (ACT) for the Treatment of Female SUI
Recruiting
A prospective, single arm, non-randomized, multicenter, prospective case-series trial. The purpose of this trial is to demonstrate the safety and effectiveness of using the Adjustable Continence Therapy (ACT) to provide a clinically relevant improvement in stress urinary incontinence.
Gender:
Female
Ages:
22 years and above
Trial Updated:
05/19/2023
Locations: University of Colorado, Denver, Colorado
Conditions: Urinary Incontinence, Urinary Incontinence,Stress
ProACT Post-Approval Study
Recruiting
The ProACT Post Approval Study is a 5-year prospective, open-label, multi-center study designed to evaluate the long-term incidence of urethral stricture and device erosion after ProACT implantation. In addition, the study will evaluate whether treatment with ProACT affects clinical outcomes after subsequent SUI therapies.
Gender:
Male
Ages:
50 years and above
Trial Updated:
05/19/2023
Locations: University of Colorado, Denver, Colorado
Conditions: Stress Urinary Incontinence
Werewolf Flow 50 During ACL Reconstruction
Recruiting
The aim of this study is to compare the outcomes, ease of use, and cost of the Werewolf FLOW50 device to the institutional standard of care which is does not include the use of electrocautery devices during anterior cruciate ligament reconstruction (ACLR) surgery in patients 12-18 years of age using a randomized control trial design. The investigators hypothesize that a lower proportion of participants who undergo ACLR and are randomized to the Werewolf FLOW50 procedure will experience post-ope... Read More
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
05/18/2023
Locations: Children's Hospital Colorado,, Aurora, Colorado
Conditions: Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Arthrofibrosis of Knee
Exploring the Anti-inflammatory Properties of Cannabis and Their Relevance to Insulin Sensitivity
Recruiting
This study tests the effects of cannabinoid levels in blood on inflammation and insulin sensitivity both acutely and chronically in individuals across the weight spectrum. To that end, the study employs two observational designs: 1) A study of acute effects with intermittent cannabis users and 2) A study in which current cannabis users will select one of three cannabis strains for four weeks and are compared to a matched control group who do not use cannabis to study chronic effects. Blood level... Read More
Gender:
All
Ages:
Between 21 years and 40 years
Trial Updated:
05/18/2023
Locations: Center for Innovation and Creativity, Boulder, Colorado
Conditions: Type 2 Diabetes, Obesity, Cannabis Use, Insulin Sensitivity
Activity Restrictions After Inguinal Hernia Repair
Recruiting
This research is intended to be a pilot study to identify differences in outcomes for varied lifting and physical activity precautions following surgical repair of single-sided inguinal hernias. The researchers hypothesize that when given the autonomy to return to activity at the patient's discretion, convalescence will decrease in comparison to a control group given specific precautions to refrain from lifting and strenuous activity. Specific aims include differences in convalescence and surgic... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
05/16/2023
Locations: Rocky Mountain Regional VA Medical Center, Aurora, Colorado
Conditions: Inguinal Hernia
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
Recruiting
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week washout.
Gender:
All
Ages:
12 years and above
Trial Updated:
05/16/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Asthma
In-person vs. Virtual Delivery of a Group-based Prevention of Postpartum Depression
Recruiting
The goal of this clinical trial is to test whether an established preventive intervention (group interpersonal therapy) delivered virtually shows the same benefits for preventing postpartum depression as it does when delivered in person.
Gender:
Female
Ages:
18 years and above
Trial Updated:
05/15/2023
Locations: Denver Health Medical Center, Denver, Colorado
Conditions: Postpartum Depression
Nitrite-boosting Therapy for Improving Physiological Function in Patients With Chronic Kidney Disease
Recruiting
Nitric oxide (NO) is an essential molecule in the body that is decreased in patients with chronic kidney disease (CKD), leading to reductions in vascular, movement ("motor") and cognitive functions. This study will determine if daily oral supplementation (3 months) with a supplement that increases NO in the body, i.e., nitrate-rich beetroot juice, improves vascular, motor and cognitive function in patients with CKD; this study will also provide insight into the biological reasons (mechanisms) by... Read More
Gender:
All
Ages:
Between 30 years and 80 years
Trial Updated:
05/15/2023
Locations: Integrative Physiology of Aging Laboratory, Boulder, Colorado
Conditions: Chronic Kidney Disease
Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 1
Recruiting
This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory task after self-administering one of three different strains of cannabis flower one day and while not intoxicated another day. Event-related potentials (ERPs) are measured via electroencephalogram (EEG) during the recognition memory task. Blood is collected to quantify THC and CBD exposure. Participan... Read More
Gender:
All
Ages:
Between 21 years and 40 years
Trial Updated:
05/11/2023
Locations: Center for Innovation and Creativity, Boulder, Colorado
Conditions: Cannabis, Memory, Electroencephalography
MitoQ and Exercise Effects on Vascular Health
Recruiting
An impairment in vascular function can lead to the development of age-associated cardiovascular disease (CVD), the leading cause of death in postmenopausal women. Regular aerobic exercise (AE) benefits vascular function in older men by reducing oxidative stress, however, similar AE training improvements are diminished or absent in postmenopausal women. not using estrogen-based hormone therapy. Vascular function and oxidative stress are improved with AE training in postmenopausal women treated wi... Read More
Gender:
Female
Ages:
Between 50 years and 120 years
Trial Updated:
05/10/2023
Locations: University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research Laboratory, Aurora, Colorado
Conditions: Aging, Menopause
Miniscrew Stability and Peri-implant Inflammation When Precoated K21 vs Ethanol Control
Recruiting
To determine if coating miniscrews with K21 would increase the success rate of orthodontic miniscrews by reducing adjacent tissue inflammation.
Gender:
All
Ages:
12 years and above
Trial Updated:
05/10/2023
Locations: University of Colorado School of Dental Medicine, Aurora, Colorado
Conditions: Inflammation Caused by the Placement of a Temporary Anchorage Device