Colorado is currently home to 1917 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Prospective Evaluation of PRP and BMC Treatment to Accelerate Healing After ACL Reconstruction
Recruiting
This is a prospective, randomized, placebo-controlled trial to evaluate potential beneficial effects of leukocyte-poor platelet rich plasma and bone marrow concentrate on the healing and health of critical joint tissues in the knee following anterior cruciate ligament (ACL) reconstruction. Bone marrow contains stem cells which can change into cells of various different tissue types, while platelet rich plasma contains growth factors. This trial will compare the two procedures against placebo.
Gender:
All
Ages:
Between 16 years and 50 years
Trial Updated:
04/19/2023
Locations: 181 West Meadow Drive, Suite 1000, Vail, Colorado
Conditions: Osteoarthritis, Knee
Etonogestrel Implant as Emergency Contraception
Recruiting
The investigators propose a single site, single arm, open label mechanism of action pharmacodynamic pilot study of etonogestrel implant insertion prior to an luteinizing hormone (LH) surge. The investigators will evaluate ovulation rates via serum levels of reproductive hormones and transvaginal ultrasound findings following placement of an etonogestrel implant once the dominant follicle reaches a size of 15mm or greater, but prior to an LH surge, in persons with prior documented regular cycles... Read More
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
04/18/2023
Locations: University of Colorado Denver, Aurora, Colorado
Conditions: Contraception
Countermeasures to Circadian Misalignment
Recruiting
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize meta... Read More
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
04/18/2023
Locations: Colorado State University, Fort Collins, Colorado
Conditions: Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. Until recently, the mainstay of treatment for these patients was supportive medical care. Howe... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Spinal Muscular Atrophy (SMA)
Clinical Outcomes Study of the Nexel Total Elbow
Recruiting
The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Panorama Orthopedics and Spine Center, Golden, Colorado
Conditions: Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis, Joint Instability or Loss of Motion, Acute Comminuted Articular Fracture of Elbow Joint Surfaces, Bone Loss Contributing to Elbow Instability, Bilateral Ankylosis From Causes Other Than Active Sepsis, Post-traumatic Arthritis, Degenerative Arthritis
Consistently Assess Signs and Symptom of Heart Failure
Recruiting
Heart failure (HF) is a major public health problem. The New York Heart Association (NYHA) Functional Classification by a HF provider helps to guide their decisions in patient treatment. The purpose of this study is to further examine the NYHA Classification Guide that is designed to assist healthcare providers. The investigators will conduct the study in the outpatient clinic setting where adult patients with chronic heart failure are treated. HF providers will be asked to complete the NYHA cla... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
04/17/2023
Locations: University of Colorado Medical Center, Aurora, Colorado
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)
Recruiting
COMPASS is a prospective multicenter randomized interventional trial. Participants with ductal-dependent pulmonary blood flow will be randomized to receive either a systemic-to-pulmonary artery shunt or ductal artery stent. Block randomization will be performed by center and by single vs. two ventricle status. Participants will be followed through the first year of life.
Gender:
All
Ages:
Between 1 day and 30 days
Trial Updated:
04/12/2023
Locations: Children's Hospital of Colorado, Aurora, Colorado
Conditions: Congenital Heart Disease in Children
Biomarker Cost-Benefit Analysis of EFNEP
Recruiting
The goal of this integrated project is to assess whether EFNEP is a cost-effective nutrition education intervention that generates sustained improvement in chronic disease biomarkers. This project will be unique in its use of objective biomarkers, instead of self-reported behaviors, to quantify the economic benefits generated by EFNEP through chronic disease prevention. A paired location untreated control group quasi-experimental design will be employed, with biomarkers (BMI, blood pressure, HbA... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
04/11/2023
Locations: Colorado State University, Fort Collins, Colorado
Conditions: Chronic Disease
Low Energy Availability and Pituitary Function (LEAP Study)
Recruiting
The purpose of this study is to learn more about reproductive hormones and if they change in response to 5-days eating an individualized, standardized diet at two levels: energy balance and low energy intake.
Gender:
Female
Ages:
Between 18 years and 30 years
Trial Updated:
04/10/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Hypogonadotropic Hypogonadism
Adaptive Responses to Overfeeding and Weight
Recruiting
To more effectively address the problem of weight regain following weight loss for obese individuals, this study will evaluate the underlying biology of the reduced obese state. In depth studies of appetite, energy expenditure, physical activity levels and fat metabolism will be completed in obese and reduced obese individuals; with the latter subdivided into those who have lost weight with diet alone or diet plus exercise. Individuals will be studied following a brief overfeeding period to bett... Read More
Gender:
All
Ages:
Between 30 years and 50 years
Trial Updated:
04/06/2023
Locations: University of Colorado Hospital, Aurora, Colorado
Conditions: Obesity
Study to Improve Deployment Related Asthma by Using L-Citrulline Supplementation
Recruiting
Service men and women returning from deployment are significantly more likely to develop asthma and severe respiratory symptoms from airway obstruction. Why this happens is not well known, but exposure to diesel, burn pits, biomass smoke, and sandstorms are thought to play a role. Ultimately, patients with deployment related asthma develop a complex airway disease that does not respond well to standard asthma medications. Therefore, it is imperative that safe and affordable treatments that could... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/04/2023
Locations: National Jewish Health, Denver, Colorado
Conditions: Post Deployment Related Asthma, Asthma
Phase 1 Study of RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors
Recruiting
RBN-2397 inhibits PARP7, an enzyme that is switched on by cancer stresses, such as the toxins in cigarette smoke. Cancer cells use PARP7 to hide from the immune system by stopping the cell from sending a signal (Type 1 interferon) that tells the immune system that something is wrong and to kill the cell. RBN-2397 has been shown in animal studies to inhibit tumor growth and also shuts down the "don't kill me" signal the tumor is sending to evade the immune system. As a PARP7 inhibitor RBN-2397 is... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Solid Tumor, Adult