Colorado is currently home to 1777 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Sputum Studies of Anti-Citrullinated Protein Antibodies (ACPA) and Rheumatoid Arthritis (RA) Origins
NCT04474392
Recruiting
The study is designed to learn more about the causes of rheumatoid arthritis (RA). People who get RA have elevated protein markers called autoantibodies in their blood years before initial symptoms of arthritis. The goal of this study is to learn more about how autoantibodies in RA might be related to inflammation in the lungs.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/13/2022
Locations: University of Colorado Denver (Anschutz Medical Campus), Aurora, Colorado
Conditions: Rheumatoid Arthritis
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Non-Guided vs. Guided Surgery to Immediately Loaded PrimeTaper Implants in Partially Edentulous Patients
NCT05264545
Recruiting
A 510k approved dental device for subjects requiring single or multiple tooth replacement with implants where immediate restoration/loading is preferred.
Gender:
ALL
Ages:
25 years and above
Trial Updated:
05/25/2022
Locations: McClain and Schallhorn Periodontics and Implant Dentistry, Aurora, Colorado
Conditions: Partially Edentulous Maxilla or Mandible
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Parents Advancing Toddler Health
NCT04824989
Recruiting
Although early interventions can improve health equity in young children living in poverty, this promise often is not realized because of barriers to family engagement. The proposed study will target co-morbid behavior and sleep problems in early childhood, comparing child outcomes and family response to sleep and behavior interventions and investigating the novel strategy of letting families select their intervention.We will enroll 500 low-income toddlers with co-morbid sleep and behavior probl... Read More
Gender:
ALL
Ages:
Between 18 months and 48 months
Trial Updated:
04/01/2022
Locations: University of Denver, Denver, Colorado
Conditions: Sleep Problem, Behavior, Child
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PPROM Registry (Preterm Premature Rupture of Membranes)
NCT02997345
Recruiting
Preterm Premature Rupture of Membranes (PPROM) before 37 weeks of pregnancy is responsible for 40% of preterm births in the United States. The PPROM Registry aims to identify possible causes of PPROM, evaluate trends in expectant management, measure maternal and fetal care, and to review short term and long term outcomes of affected pregnancies and births.
Gender:
FEMALE
Ages:
Between 14 years and 55 years
Trial Updated:
02/14/2022
Locations: Www.Aapprom.Org/the-Registry, Denver, Colorado
Conditions: Fetal Membranes, Premature Rupture, Preterm Premature Rupture of the Membranes, Oligohydramnios, Premature Birth
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An Outcomes Study Utilizing Allomend(R) HD for Superior Capsular Reconstruction
NCT04615117
Recruiting
Rotator cuff tears can usually be repaired with excellent results, however some chronic, extensive rotator cuff tears are not reparable secondary to tendon retraction with inelasticity, muscle atrophy, and fatty infiltration. Arthroscopic superior capsular reconstruction (SCR) utilizing allograft or autograft tissue has been shown to restore superior glenohumeral stability and function of the shoulder joint in patients with irreparable rotator cuff tears. Grafts utilized for SCR have included fa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2021
Locations: Western Orthopaedics Education and Research Foundation, Denver, Colorado
Conditions: Rotator Cuff Tear or Rupture, Not Specified as Traumatic
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The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL
NCT03509961
Recruiting
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regime... Read More
Gender:
ALL
Ages:
Between 1 year and 25 years
Trial Updated:
08/20/2021
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: B-cell Acute Lymphoblastic Leukemia
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Home Based Infusions for Ocrelizumab
NCT04650321
Recruiting
The goal is to assess the safety and effectiveness of home ocrelizumab infusion.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/08/2021
Locations: Amerita, Centennial, Colorado
Conditions: Multiple Sclerosis
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Objective Measures of Nerve Integrity, Posture, Gait and Blood Flow, After Nerve Decompression
NCT01735903
Recruiting
The purpose of this study is to measure the effect of nerve decompression on the recovery of the treated nerves. To obtain objective data during surgery of the treated nerves' via electrical signals and muscle power when stimulated. Also, to monitor muscle strength, balance/gait and blood flow in the lower extremity before and after surgery.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
02/15/2021
Locations: Anderson Podiatry Center, Neuropathy Testing Center of Colorado, Fort Collins, Colorado
Conditions: Diabetic Peripheral Neuropathy
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An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04718818
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Colorado Springs, Colorado
Conditions: Ulcerative Colitis
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Evaluation of SUMMIT BRUSH in Treatment of Blepharitis
NCT04603222
Recruiting
Dry Eye Disease (DED) is a multifactorial disease that affects \~15-30 million people in the USA alone. It creates an enormous societal and economic burden, decreases productivity in the workplace, and affects the quality of lives of the people affected by this disease. DED is primarily caused by blepharitis, a chronic inflammation of the eyelid margins. If left untreated, blepharitis results in the obstruction and loss of the glands responsible for tear film production. The standard of care is... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/24/2020
Locations: University of Colorado, Boulder, Colorado
Conditions: Blepharitis
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Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)
NCT01088217
Recruiting
The purpose of this study is to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis and to identify a group of genes that predispose individuals to develop pulmonary fibrosis. Finding the genes that cause pulmonary fibrosis is the first step at developing better methods for early diagnosis and improved treatment for pulmonary fibrosis. The overall hypothesis is that inherited genetic factors predispose individuals to develop pulmonary fibrosis... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/11/2020
Locations: University of Colorado Denver, Aurora, Colorado
Conditions: Idiopathic Pulmonary Fibrosis, Familial Pulmonary Fibrosis, Idiopathic Interstitial Pneumonia, Familial Interstitial Pneumonia
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Cardiovascular Innovation & Research Institute 's NEXUS Registry, the Whole is Greater Than the Parts.
NCT03428048
Recruiting
Information gathered from the patients via a disease specific questionnaire will be married to data from the National Cardiovascular Data Registry (NCDR®). Details will be continuously analyzed and used to direct quality of care at our center. The institution is categorized as a low-volume institution for percutaneous coronary intervention (PCI) for coronary artery disease treatment as well as surgical and endocardial ablation for the management of atrial fibrillation (Afib). The association bet... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/29/2020
Locations: Valley View Hospital, Glenwood Springs, Colorado
Conditions: Coronary Artery Disease, Atrial Fibrillation (AF)
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