There are currently 268 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt
NCT05183230
Recruiting
The goal of this project is to test whether WellPATH-PREVENT (a novel, mobile psychosocial intervention) improves a specific aspect of emotion regulation, i.e., cognitive reappraisal ability, and reduces suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a suicide-related hospitalization (i.e. for suicidal ideation or suicide attempt).
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
11/22/2024
Locations: New York Presbyterian Hospital/Weill Cornell Medicine, New York, New York +1 locations
Conditions: Suicide, Attempted, Suicidal Ideation, Depression
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Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
NCT06538246
Recruiting
Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common. These can lead to high rates of depression, anxiety, and PTSD that worsen quality of life. Yet there are few effective strategies able to overcome barriers of limited access to mental health care. Even less is known about the experiences of patients from racially and ethnically minoritized populations because of they haven't b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Depression, Anxiety, Post-traumatic Stress Disorder, Stress, Worries; Pain or Disability, Breath Shortness
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Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
NCT05474846
Recruiting
To learn if Cognitive Behavior Therapy (called CBT), combined with either Bright Light Therapy (called BLT), methylphenidate, and/or melatonin, can help improve sleep and other related symptoms such as fatigue, anxiety, and depression in cancer patients. This is an investigational study. In this study, BLT, Methylphenidate and Melatonin will be compared to their placebos.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Sleep, Fatigue, Anxiety, Cancer, Depression
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Brief Interventions for Coping with Distress
NCT05779761
Recruiting
This study is being done to compare the effectiveness of three different skills trainings to cope with distress. These three trainings are: 1) an attention skills training, 2) an attention and reflective thought skills training, and 3) a health and wellness education training.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/18/2024
Locations: Teachers College, Columbia University, New York, New York
Conditions: Distress, Emotional, Emotional Dysfunction, Anxiety, Depression
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Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches
NCT05176392
Recruiting
This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide marked reduction in mTBI related headaches and symptoms in comparison to their placebo counterparts.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/18/2024
Locations: VA San Diego Healthcare System, San Diego, California
Conditions: TBI (Traumatic Brain Injury), Headache, Depression
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Brain Stimulation and Decision-making
NCT04099056
Recruiting
Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in this process, it remains unclear exactly how these regions are influencing choice behavior especially when choices become more challenging. The goal of this project is to understand how these regions, such as the cingulate cortex, impact difficult choice behavior. Specifically, the researchers are i... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/14/2024
Locations: Emory University, Atlanta, Georgia
Conditions: Depression
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Compassion Meditation vs. Health Education for Veterans
NCT04651296
Recruiting
Chronic pain (CP) is a major health problem for military Veterans, and CP is often associated with comorbid mental health problems, including posttraumatic stress disorder (PTSD) and depression. CP with psychological comorbidity is associated with increased healthcare costs, medication use, risk of suicide and rates of disability and reduced quality of life. Current empirically supported treatments do not always lead to substantial improvements (up to 50% of patients drop out or are do not respo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Chronic Pain, Stress Disorders, Posttraumatic, Depression
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Study on Allopregnanolone and Depression in Women Across the Menopause Transition
NCT06238700
Recruiting
This study aims to identify how enhanced allopregnanolone activity (via pregnenolone) affects behavior and neurobiology that may underlie perimenopausal depression.
Gender:
FEMALE
Ages:
Between 40 years and 60 years
Trial Updated:
11/13/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Depression
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Families With Pride ("Familias Con Orgullo").
NCT06057337
Recruiting
This study will evaluate the effects of a parenting intervention for Hispanic sexual minority youth in preventing/reducing drug use and depressive symptoms. It will also examine whether the intervention improves parent social support for the adolescent, parent acceptance, family functioning, and whether it reduces general stress and stress associated with being a Hispanic sexual minority.
Gender:
ALL
Ages:
Between 13 years and 19 years
Trial Updated:
11/12/2024
Locations: University of Miami, Coral Gables, Florida
Conditions: Depression, Drug Use
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Kind Minds Program for Youth with Anxiety and Depression
NCT05353751
Recruiting
Rates of anxiety and depression in youth are substantial, causing a major unmet need for effective interventions. Participation in mindfulness interventions has been demonstrated to reduce anxiety and depressive symptoms among teenagers. Parents' participation in mindfulness interventions has also been shown to reduce their children's mental health symptoms. However, there is no available evidence regarding potential additional benefits for adolescents' mental health of having both the adolescen... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
11/12/2024
Locations: Imperial High School, Imperial, California
Conditions: Child Anxiety, Depression
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MRI-Guided High-Definition Transcranial Direct Current Stimulation (tDCS) for Depression
NCT05090397
Recruiting
The purpose of this research is to understand how a neurostimulation technique, transcranial electrical stimulation (tES), affects brain function in adults with major depression measured with functional magnetic resonance imaging (fMRI). This study targets a specific kind of tES called transcranial direct current stimulation (tDCS), where a mild, constant current is passed between electrodes placed on the scalp.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/12/2024
Locations: CTI Northwestern, Chicago, Illinois
Conditions: Depression
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Digital Mental Health Intervention for Nonsuicidal Self-Injury in Young Adults
NCT05325944
Recruiting
This is a feasibility trial of a digital mental health intervention aimed at young adults (ages 18-25) with nonsuicidal self-injury and who are not currently engaged in mental health treatment. We will pilot three arms: a self-guided DMHI, the DMHI with low-intensity coaching, or an active control which will involve the delivery of non-interactive psychoeducational content via the same app interface. The primary goals of this project are to evaluate the feasibility of the intervention and trial... Read More
Gender:
ALL
Ages:
Between 18 years and 24 years
Trial Updated:
11/12/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Nonsuicidal Self Injury, Suicidal Ideation, Depression, Anxiety
Register for Updates