There are currently 267 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study
NCT04663841
Recruiting
This study is currently recruiting Veterans only. The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. We focus on cognitive network connectivity as a predictive biomarker of the clinical effect of TMS, and as a response biomarker of change with TMS. We address this objective through a pragmatic approach in which we recruit patients undergoin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Stanford University Department of Psychiatry, Stanford, California
Conditions: Depression
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Brief, High-dose rTMS for Depression
NCT04657432
Recruiting
High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination. The purpose of this study is to systematically examine an accelerated protocol of intermittent theta burst (iTBS). Study 1 aims to provide a quantifiable dose-response curve for iTBS and depressive symptom reduction in major depression. Study 2 aims to determine the role of indi... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
03/01/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Depression, Anxiety
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Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)
NCT05356364
Recruiting
Nearly half of women develop insomnia during pregnancy, which is associated with increased risk for developing perinatal depression. The purpose of this research is to evaluate the implementability and effectiveness of a mindfulness-based therapy for insomnia relative to cognitive-behavioral therapy for insomnia in pregnant women with insomnia and comorbid depression. The investigators aim to examine whether a mindfulness-based intervention effectiveness reduces symptoms of insomnia and comorbid... Read More
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
02/29/2024
Locations: Henry Ford Medical Center, Novi, Michigan
Conditions: Insomnia, Depression
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Mechanisms of Behavioral Activation (BA)
NCT05548244
Recruiting
The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonance imaging (fMRI). In particular, the project seeks to determine whether BA targets different neural mechanisms for behavioral avoidance associated with low motivation as compared to threat avoidance. A group of healthy controls will also be scanned as a comparator group for behavioral and imaging m... Read More
Gender:
All
Ages:
Between 15 years and 17 years
Trial Updated:
02/29/2024
Locations: Emory University, Atlanta, Georgia +2 locations
Conditions: Depression
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A Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis
NCT05865405
Recruiting
The researchers want to find out if an electronic application called MS CATCH can enhance patients' and doctors' experiences during and in between clinical visits. MS CATCH is a smartphone-based tool which allows patients to enter their mood related symptoms at regular intervals, which is then available to their Neurologist in their electronic medical record. The neurologist is also able to view additional information from their medical record, and receives alerts for changes reported by the pat... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/16/2024
Locations: Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California
Conditions: Multiple Sclerosis, MS, Depression
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Evaluating Process of Change in Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for Depression
NCT06245096
Recruiting
This study will compare two psychological treatments for major depressive disorder (MDD): cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT). Both treatments are well-studied and supported by evidence as effective options for people experiencing depression. These treatments will be delivered in an online group format via Zoom. The study will enroll up to 150 participants with depression. Half of the participants will receive online group CBT and half will receive onl... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Depression
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The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
NCT06011681
Recruiting
Mild cognitive impairment (MCI) leading to Alzheimer's disease and related disorders (ADRD) represents a significant health and economic burden of the rapidly expanding senior population. The accurate detection and diagnosis of MCI and its common comorbidity, late-life depression (LLD), is essential for prolonging patient quality of life and developing advancements in research and treatment options. The purpose of the proposed program is to refine Miro Health's A.I. to accurately detect, differe... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
01/18/2024
Locations: Miro Health, Sacramento, California +1 locations
Conditions: Depression, Mild Cognitive Impairment
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Amplification of Positivity for Alcohol Use
NCT06030154
Recruiting
The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (AMP-A). These participants will be asked to provide both qualitative and quantitative input about the AMP-A intervention. Based on their input and clinician input, the AMP-A manual will be modified for... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/18/2024
Locations: Laureate Institute for Brain Research, Tulsa, Oklahoma
Conditions: Alcohol Use Disorder, Anxiety, Depression
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Expanding First-line Options for Depression and Matching Treatments to Patients: Hatha Yoga vs. Behavioral Therapy
NCT05546697
Recruiting
This is a parallel group study design. The investigators propose to compare an online, synchronous group-based yoga intervention developed for individuals with depression to an online, synchronous individualized, evidence-based behavioral therapy for depression, or Brief Behavioral Activation Treatment for Depression (BA). This study is a multi-site randomized trial of adults with clinically significant depressive symptoms. Participants (N=518) will be randomized in an equal allocation ratio (i.... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/09/2024
Locations: Antonietta Alvarez Hernandez, Boston, Massachusetts
Conditions: Depression
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Implementation of the Parents Taking Action in Paraguay
NCT05780138
Recruiting
The principal aim of this study is to conduct a single group design pilot of a psychoeducational caregiver training (i.e., culturally adapted Parents Taking Action) with a group of family caregivers of young children with autism in Paraguay. The following research questions will be addressed: Research Question #1: What is the feasibility and acceptability of the intervention? Research Question #2: Do participants improve between pre and post-test on outcome measures? Parents will receive 10 wee... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
01/04/2024
Locations: University of Texas at Austin, Austin, Texas
Conditions: Depression, Autism
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Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Conditions
NCT06190184
Recruiting
US residents who have obesity and sign the informed consent form and are screened and enrolled for this study. Participants who are enrolled complete a survey upon enrollment and are randomized into one of two arms. This study is direct to participant and will not utilize clinical sites.
Gender:
All
Ages:
25 years and above
Trial Updated:
01/03/2024
Locations: Viome Life Sciences, Bothell, Washington
Conditions: Mental Health Issue, Mental Health Disorder, Mental Health, Depression, Depression, Anxiety, Anxiety, Anxiety Disorders, Anxiety Depression, Anxiety State
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Poststroke Depression in Hemorrhagic Stroke
NCT03826875
Recruiting
A double-blinded placebo-controlled randomized trial to evaluate the effect of preventative treatment of depression in survivors of aneurysmal subarachnoid hemorrhage (aSAH), a type of stroke.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
11/27/2023
Locations: Harborview Medical Center, Seattle, Washington
Conditions: Stroke Hemorrhagic, Depression
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