There are currently 255 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies
NCT06432959
Recruiting
In this study, the investigators will test whether the incorporation of positive affect promoting activities in treatment sessions improves outcomes in the context of CBT for depression and DBT for problems of emotion dysregulation. In clinics focused on each of these treatments, the investigators will evaluate these treatments with and without the addition of positive affect promoting activities.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/24/2024
Locations: Department of Psychology, The Ohio State University, Columbus, Ohio
Conditions: Depression, Borderline Personality Disorder, Emotion Regulation
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Ketogenic Intervention in Depression
NCT06080932
Recruiting
The goal of this study is to examine whether a well-formulated ketogenic diet (KD) can be implemented into a university counseling treatment program for major depression and to test whether such a program has any benefit on mental and metabolic health.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
04/01/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Depression, Ketosis
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Positive Processes and Transition to Health - Single-Session (PATH-SS)
NCT06900712
Recruiting
The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a sexual assault. This research will explore whether this new psychotherapy reduces sexual assault related distress, including posttraumatic stress and depression symptoms. The main questions it aims to answer are: Does PATH-SS leads to improvements in PTSD and depressio... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/22/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: PTSD, Depression
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TEAM-Red, a Remotely Delivered Self-management Program for Depressed Black Women at Risk for Hypertension
NCT05488782
Recruiting
The proposed project is a 24-week prospective randomized controlled trial (RCT) evaluating the effects of TargEted MAnageMent Intervention (TEAM, N=41) vs. enhanced waitlist (eWL, N=41) control in young (\<50 years) African American women who are depressed or suffering from stress, and at risk for hypertension.
Gender:
FEMALE
Ages:
Between 18 years and 49 years
Trial Updated:
10/04/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Depression
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Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
NCT04245748
Recruiting
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/28/2024
Locations: University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience, Cincinnati, Ohio
Conditions: Anxious Depression, Depression
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Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
NCT03336918
Recruiting
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/05/2024
Locations: Cleveland Clinic Foundation Center for Behavioral Health, Cleveland, Ohio
Conditions: Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode
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CAMPUS Expanded "Classification and Assessment of Mental Health Performance Using Semantics Expanded"
NCT04493736
Recruiting
Open enrollment study to collect data for the optimization of machine learning models for use in an app for the early detection of mental health and suicidal risk.
Gender:
ALL
Ages:
Between 8 years and 75 years
Trial Updated:
02/05/2024
Locations: Clarigent Health, Mason, Ohio
Conditions: Suicide, Suicidal, Suicide, Attempted, Suicidal Ideation, Depression, Anxiety, Aggression, Trauma, Psychological
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A Digital Intervention for Post-Stroke Depression and Executive Dysfunction
NCT05507138
Recruiting
Individuals with stroke commonly experience both depression and cognitive difficulties. The goal of this study is to evaluate the efficacy of a treatment that combines a digital therapeutic (an iPad-based cognitive training program) with learning cognitive strategies. The hypotheses are that this treatment will improve cognitive skills, depression symptoms, daily function, and brain connectivity. In the short-term, the findings will inform the efficacy of the intervention and in the long-term, m... Read More
Gender:
ALL
Ages:
Between 50 years and 79 years
Trial Updated:
05/23/2025
Locations: Weill Cornell Medical Center, New York, New York
Conditions: Executive Dysfunction, Depression, Stroke
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Neurobiology of Suicide
NCT02543983
Recruiting
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people. Objective: To understand what happens in the brain when someone has thought about or attempted suicide. Eligibility: Group 1: Adults ages 18 70 who have thought about or attempted suicide recently Group 2: Adults ages 18 70 who have thought about or... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/23/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteers, Depression
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Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD
NCT06928467
Recruiting
Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role. These caregivers express a desire for education and support. The overarching goal of this project is to improve education and support for caregivers of persons living with dementia so that they can take better care of themselves and also their person living with dementia. Building Better Caregivers workshop i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: University of California, San Francisco, San Francisco, California +1 locations
Conditions: Family Caregivers, Dementia, Self-management, Depression, Internet-based Intervention
Register for Updates
Inflammation and Depression in People With HIV
NCT05849038
Recruiting
The purpose of this 10-week, double-blind, placebo-controlled study is to determine whether inflammation impacts reward and motor neural circuitry to contribute to depressive symptoms like anhedonia and psychomotor slowing in people with Human Immunodeficiency Virus (HIV) and depression. Sixty male and female patients with HIV who have depression, anhedonia and high inflammation and are stable on effective treatment for their HIV will be randomized to receive either the anti-inflammatory drug ba... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/21/2025
Locations: Grady Memorial Hospital, Atlanta, Georgia +1 locations
Conditions: HIV, Depression, Anhedonia
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Sequential Multiple Assignment Randomized Trial for Bipolar Depression
NCT06433635
Recruiting
This is a sequential multiple assignment randomized trial for adults (ages \> 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic trial that will compare four commonly prescribed treatments for bipolar depression, which includes three FDA-approved medications (Cariprazine, Quetiapine and Lurasidone) and one antipsychotic/antidepressant combination (Aripiprazole/Escitalopram).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/21/2025
Locations: University of Alabama Birmingham, Birmingham, Alabama +16 locations
Conditions: Bipolar I Disorder, Depression
Register for Updates