There are currently 253 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies
Recruiting
In this study, the investigators will test whether the incorporation of positive affect promoting activities in treatment sessions improves outcomes in the context of CBT for depression and DBT for problems of emotion dysregulation. In clinics focused on each of these treatments, the investigators will evaluate these treatments with and without the addition of positive affect promoting activities.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/24/2024
Locations: Department of Psychology, The Ohio State University, Columbus, Ohio
Conditions: Depression, Borderline Personality Disorder, Emotion Regulation
Ketogenic Intervention in Depression
Recruiting
The goal of this study is to examine whether a well-formulated ketogenic diet (KD) can be implemented into a university counseling treatment program for major depression and to test whether such a program has any benefit on mental and metabolic health.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
04/01/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Depression, Ketosis
Positive Processes and Transition to Health - Single-Session (PATH-SS)
Recruiting
The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a sexual assault. This research will explore whether this new psychotherapy reduces sexual assault related distress, including posttraumatic stress and depression symptoms. The main questions it aims to answer are: Does PATH-SS leads to improvements in PTSD and depressio... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/22/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: PTSD, Depression
TEAM-Red, a Remotely Delivered Self-management Program for Depressed Black Women at Risk for Hypertension
Recruiting
The proposed project is a 24-week prospective randomized controlled trial (RCT) evaluating the effects of TargEted MAnageMent Intervention (TEAM, N=41) vs. enhanced waitlist (eWL, N=41) control in young (\<50 years) African American women who are depressed or suffering from stress, and at risk for hypertension.
Gender:
FEMALE
Ages:
Between 18 years and 49 years
Trial Updated:
10/04/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Depression
Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
Recruiting
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/28/2024
Locations: University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience, Cincinnati, Ohio
Conditions: Anxious Depression, Depression
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Recruiting
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/05/2024
Locations: Cleveland Clinic Foundation Center for Behavioral Health, Cleveland, Ohio
Conditions: Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode
CAMPUS Expanded "Classification and Assessment of Mental Health Performance Using Semantics Expanded"
Recruiting
Open enrollment study to collect data for the optimization of machine learning models for use in an app for the early detection of mental health and suicidal risk.
Gender:
ALL
Ages:
Between 8 years and 75 years
Trial Updated:
02/05/2024
Locations: Clarigent Health, Mason, Ohio
Conditions: Suicide, Suicidal, Suicide, Attempted, Suicidal Ideation, Depression, Anxiety, Aggression, Trauma, Psychological
Probiotic Administration for Adolescent Depression
Recruiting
This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age.
Gender:
ALL
Ages:
Between 15 years and 24 years
Trial Updated:
05/05/2025
Locations: UCSF, San Francisco, California
Conditions: Depression
Resilience in Adolescent Development
Recruiting
RAD is a 10-year natural history, longitudinal, prospective assessment study of a cohort of 2,500 participants (ages 10-24 years) that will help uncover the socio-demographic, lifestyle, clinical, psychological, and neurobiological factors that contribute to resilience among children, adolescents, and young adults at-risk for mood and anxiety disorders. As this is an exploratory study, we will assess a comprehensive panel of carefully selected participant specific parameters, including socio-dem... Read More
Gender:
ALL
Ages:
Between 10 years and 24 years
Trial Updated:
05/04/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Risk Assessment, Resilience, Psychological, Depression, Mood Disorders, Anxiety Disorders, Mental Health
Neurobiology of Suicide
Recruiting
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people. Objective: To understand what happens in the brain when someone has thought about or attempted suicide. Eligibility: Group 1: Adults ages 18 70 who have thought about or attempted suicide recently Group 2: Adults ages 18 70 who have thought about or... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/03/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteers, Depression
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
Recruiting
The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. In addition the protocol will allow clinicians to gain more experience in the use of a variety of polysomnographic and high-density EEG recordings. Subjects in this protocol will undergo an evalua... Read More
Gender:
ALL
Ages:
Between 3 years and 99 years
Trial Updated:
05/02/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression, Mood Disorders, Anxiety Disorders, Healthy Volunteers, Bipolar Disorder
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Recruiting
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect. For most people, this lasts a week or less. Repeated doses of ketamine may help maintain this effect. Objective: Main Study: To study the effects of ketamine in treating depression. Ketamine Metabolites Substudy: To study how ketamine effects brain chemistry. To study how ketamine effects the brain. This... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/02/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteer, Major Depressive Disorder, Depression