There are currently 268 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
Concurrent TMS-fMRI
NCT06633913
Recruiting
The goal of this clinical trial is to examine the neural mechanisms underlying transcranial magnetic stimulation (TMS) using concurrent functional magnetic resonance imaging (fMRI) in both healthy controls (HCs) and patients with high negative affect symptoms, such as depression and anxiety. Approximately half male and half female participants aged 18-65 will be recruited. The main questions it aims to answer are: 1. Is the acute/transient effect induced by single-pulse TMS related to the long... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/16/2024
Locations: University of Iowa Carver College of Medicine, Iowa City, Iowa
Conditions: Healthy Control, Depression, Anxiety
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Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
NCT05117255
Recruiting
This project is designed to determine if a computer-delivered cognitive-behavioral treatment can improve the otherwise poor alcohol use disorder treatment outcomes for individuals with a co-occurring anxiety disorder. In the past, the investigators showed that this treatment does improve outcomes for these individuals when delivered by a therapist. If the present work shows that the computer-delivered version is also effective, it would provide an inexpensive program with virtually unlimited sca... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/11/2024
Locations: Lodging Plus Program, Fairview Hospital, Minneapolis, Minnesota
Conditions: Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, Alcohol Use Disorder, Depression
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Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
NCT06523439
Recruiting
This is a single-site open-label clinical trial of the Stanford Accelerated Intermittent Neuromodulation Therapy (SAINT®) protocol. The goal of this clinical trial is to learn if a new form of transcranial magnetic stimulation (TMS)-known generally as accelerated intermittent theta burst stimulation (aiTBS) and specifically as SAINT®-is effective as a first-line therapy in treating adolescents aged 14-19 years-old in their first episode of depression who have not undergone a full course of depre... Read More
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
12/06/2024
Locations: Dell Medical School at University of Texas at Austin, Austin, Texas
Conditions: Major Depressive Disorder, Depression in Adolescence, Depression, Major Depressive Episode
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A Neuroimaging Study of Open-label Placebo in Depressed Adolescents
NCT04201106
Recruiting
Major depressive disorder (MDD) is the current leading cause of disability worldwide and adolescence is an especially vulnerable period for the onset of depression. Non-pharmacologic approaches are particularly attractive as treatment of adolescent depression due to the elevated risks of side effects related to the use of psychotropic drugs during development. A recent meta-analysis detected a positive and significant effect of non-deceptive placebos (open-label placebo, OLP) for a series of cli... Read More
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
12/05/2024
Locations: UCSF, San Francisco, California
Conditions: Depression
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Depression, Aging, Stress and Heart Health Study
NCT05570721
Recruiting
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women. The menopausal transition or perimenopause is a period of vulnerability for both depression and CVD, making it a key time to study this critical public health issue. This research will preliminarily explore whether disruption in two novel stress pathways 1) the renin-angiotensin-aldosterone system (RAAS) and autonomic nervous system (ANS) and... Read More
Gender:
FEMALE
Ages:
Between 44 years and 55 years
Trial Updated:
12/04/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Menopause, Depression, Heart Disease in Women, Stress
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Perinatal Research on Improving Sleep and Mental Health
NCT05596318
Recruiting
The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep hygiene education (SHE) for preventing perinatal depression? 2. Is the effect of digital CBT-I on perinatal depression mediated through prenatal insomnia symptom improvement? 3. Is the effect of digital CBT-I on perinatal depression moderated by baseli... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Insomnia, Depression
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Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention
NCT05965310
Recruiting
The goal of this parallel arm prospective randomized control trial study is to compare outcomes in Anterior Cruciate Ligament Reconstruction (ACLR) Surgery patients after exposure to a virtual psychological intervention (VPI) versus standard care. The main question the investigators are asking is if virtual administration of psychological CBT modules will be an accessible and convenient vehicle to improve ACLR outcomes. Participants will be placed either into a treatment group receiving virtual... Read More
Gender:
ALL
Ages:
13 years and above
Trial Updated:
12/04/2024
Locations: Henry Ford Health System, Detroit, Michigan
Conditions: Depression, Anterior Cruciate Ligament Injuries, Mental Health Issue
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Mood Lifters for Undergraduates
NCT05684120
Recruiting
Large-scale, effective, low-cost, and evidence-based programs that can nimbly translate new research discoveries into prevention and care for psychosocial-based problems are urgently needed since the vast majority of people who need evidence-based care do not receive it. The purpose of this randomized control trial is to investigate the feasibility and efficacy of a Mood Lifters group template specifically for undergraduate students. Mood Lifters is an effective peer-led program that improves o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Depression, Anxiety, Mood Disorders, Mental Health Wellness 1, Stress
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Cannabis for Palliative Care in Cancer
NCT06266611
Recruiting
Many cancer patients suffer from pain, sleep, and mood problems and are using cannabis to relieve these symptoms. Cannabis may provide such relief but may also produce negative side effects including cognitive impairment, an especially problematic issue for cancer patients, indicating more research on cannabis use in the cancer context is required. In this endeavor, the present study seeks to compare the use of hemp-derived CBD (Cannabidiol) with and without THC (Delta-9-tetrahydrocannabinol) ve... Read More
Gender:
ALL
Ages:
25 years and above
Trial Updated:
12/03/2024
Locations: Anschutz Health Sciences Building, Aurora, Colorado
Conditions: Sleep, Anxiety, Depression, Pain
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Prevention of Anhedonia in Children
NCT05988138
Recruiting
This trial will test the effects of a positive emotion-focused preventive intervention on reward responsiveness in children of mothers with histories of depression and anhedonia.
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
12/02/2024
Locations: Jesup/Hobbs Building, Nashville, Tennessee
Conditions: Anhedonia, Depression
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Equity Using Interventions for Pain and Depression
NCT06500780
Recruiting
This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https://heal.nih.gov/). This randomized controlled trial (RCT) is phase 2 of a two-phase, 5-year project with the overarching goal of testing a decision aid (DA)/coaching intervention, tailored to Black patients with comorbid chronic pain and depression, to encourage use of and adherence to nonpharmacological pain treatments (NPTs). This 2-arm trial will randomize 304 patients with comorbid chronic musculoskel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: Eskenazi Health Primary Care, Indianapolis, Indiana
Conditions: Chronic Pain, Musculoskeletal Pain, Depression, Health Equity
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Safe Mothers, Safe Children Initiative
NCT04752618
Recruiting
The purpose of this study is to assess the efficacy of the combined interventions, Skills Training in Affective and Interpersonal Regulation (STAIR) and Parent-Child Interaction Therapy (PCIT) or P-STAIR, for treating maternal PTSD and reducing maltreatment recidivism.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: McSilver Institute for Poverty Policy and Research, New York, New York
Conditions: PTSD, Depression, Child Maltreatment
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