There are currently 285 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2
NCT05708976
Recruiting
This randomized two-arm intervention trial administers 8 weekly cognitive behavioral therapy (CBT) sessions and 4 bi-weekly active whole-body hyperthermia (active WBH) sessions or 4 bi-weekly sham WBH sessions to adults aged 18 years or older with major depressive disorder (MDD).
Gender:
All
Ages:
18 years and above
Trial Updated:
05/22/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Major Depressive Disorder, Depression
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Glucose Variability and Cognition in Prediabetes
NCT04201600
Recruiting
This study examines the association of variability in glucose values over a 10-day period with cognitive function and functional status among individuals with prediabetes, aged 50 or older.
Gender:
All
Ages:
50 years and above
Trial Updated:
05/15/2023
Locations: Baltimore VA Geriatric Research Education and Clinical Center (GRECC), Baltimore, Maryland
Conditions: Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, Functional Status, PreDiabetes, Aging, Depression
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SKY Breath Intervention
NCT05388110
Recruiting
Depression is highly debilitating and prevalent among adolescents. Adolescent-onset depression is associated with long, severe, and recurrent episodes that are often not responsive to treatment. There is a dire need to develop novel treatments that are efficient, cost-effective, and tolerant for this population. Sudarshan Kriya Yoga (SKY) is a breath-based meditative practice that entails a sequence of specific breathing techniques to help practitioners achieve a state of calm alertness. It has... Read More
Gender:
All
Ages:
Between 16 years and 24 years
Trial Updated:
05/11/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Depression, Anxiety Disorders
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Depression, Experiential Diversity, and Behavioral Novelty
NCT05767554
Recruiting
The purpose of the study is to test whether changes in behavioral patterns are related to changes in depression. Depression is a psychological condition that involves persistent sad mood and/or an inability to enjoy pleasurable activities. Very stable behavioral patterns may be related to symptoms of depression. The aim of this study is to learn more about the relationship between symptoms of depression and behavioral patterns that are collected via GPS (global positioning system) location data... Read More
Gender:
All
Ages:
Between 18 years and 25 years
Trial Updated:
05/10/2023
Locations: University of Texas at Austin Institute of Mental Health Research, Austin, Texas
Conditions: Depression
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Study of a PST-Trained Voice-Enabled Artificial Intelligence Counselor(SPEAC) for Adults With Emotional Distress (Phase 2)
NCT05603923
Recruiting
Approximately 200 Participants with mild-to-moderate, untreated depression and/or anxiety will be randomly assigned (by chance, like flipping a coin) to 1 of 3 study groups: Lumen Coached Problem-Solving Treatment (PST) (n=100), Human Coached PST (n=50), and optional (delayed) Lumen Coached PST as waitlist control (n=50) to improve emotional health. All participants will complete assessments at baseline and at 18 weeks post randomization. Depending on the group assignment the PST program will b... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/09/2023
Locations: Department of Medicine, Vitoux Program on Aging and Prevention, Chicago, Illinois +1 locations
Conditions: Depression, Anxiety
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Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families
NCT05612685
Recruiting
The purpose of this study is to pilot test the feasibility, acceptability, and preliminary efficacy of healthcare provider referrals to a tax filing app within parent-child health programs to test whether such referrals can increase receipt of tax credits among low-income parents. The study will use a single-group, pre/post test design with a sample of approximately 100 women who have a child under 6 years of age. Participants will be recruited from parental-child health programs and clinics in... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
05/09/2023
Locations: UCLA School of Nursing, Los Angeles, California
Conditions: Depression, Child Development, Stress, Physical Illness, Health Care Utilization
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Anaerobic Exercise and Mental Acuity
NCT05850221
Recruiting
This is a randomized controlled trial to examine the effect of anaerobic activity (e.g., weight training) on gut microbiome metabolism and neurological health in healthy sedentary men.
Gender:
Male
Ages:
Between 18 years and 60 years
Trial Updated:
05/08/2023
Locations: 850 PBC, Phoenix, Arizona
Conditions: Depression, LPS, Mood
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Aging and Reward System Response to Inflammation and Anxiety Study
NCT05363527
Recruiting
The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation. Loss of pleasure or loss of motivation will be evaluated using self-report questionnaires, computer tasks, and during a brain scan.
Gender:
All
Ages:
Between 60 years and 80 years
Trial Updated:
05/08/2023
Locations: Norman Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, California
Conditions: Anhedonia, Inflammation, Anxiety, Aging, Depression
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Family-centered Mental Health Promotion Intervention
NCT04453709
Recruiting
Goal: The long-term goal of the proposed research program is to test the effectiveness of a preventative behavioral intervention and to scale it up for use with broader immigrant populations to reduce stress and mental health disorders. Intervention: This study plan to adapt the World Health Organization developed Problem Management Plus (PMP), an evidence based, multi-component, behavioral intervention including breathing, problem solving, behavioral activation, and social support for immigran... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: University of Massachusetts Amherst, Amherst, Massachusetts
Conditions: Stress, Psychological, Stress, Physiological, Anxiety, Depression
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Neighborhood-based Physical and Social Activity for Older Black Caregivers and People Living With Dementia
NCT05658328
Recruiting
The Sharing History through Active Reminiscence and Photo-imagery (SHARP) Program engages triads (primary caregiver, person living with dementia, caregiver support person) in walking and social reminiscence, using a group tablet to access routes and historical neighborhood images serving as conversational prompts. Focus is on adapting the SHARP model to older Black dementia caregivers and on caregiver physical and mental health. Study technology measures sleep and daily step count. Weekly online... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: Oregon Health & Science University, Portland, Oregon +1 locations
Conditions: Caregiver Burden, Depression, Cognitive Impairment
Register for Updates
Affect Treatment for Depression and Anxiety
NCT05203861
Recruiting
The purpose of this study is to evaluate the efficacy and mediators of change in Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core feature of anhedonia) in the context of depression or anxiety. Target enrollment is 100 male and female participants with low positive affect and depression or anxiety and impaired functioning, between the ages of 18 and 65 years, who will be randomized to either Positive Aff... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/08/2023
Locations: University of California, Los Angeles, Los Angeles, California +1 locations
Conditions: Depression, Anxiety
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Post-Stroke Optimization of Walking Using Explosive Resistance
NCT03826771
Recruiting
The investigators will study the effects of a 12 week strength training program on individuals who have had a stroke and are depressed to see if this type of exercise training helps treat depression and improves walking function. Our goal is to use the information collected in this study to help design treatments for people who have had a stroke that will help with many of the common consequences of stroke, including depression, muscle weakness and slow walking. Progress toward overcoming some o... Read More
Gender:
All
Ages:
Between 50 years and 70 years
Trial Updated:
05/05/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Stroke, Depression
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