There are currently 255 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Implementation of Problem-Solving Treatment in Community Health Centers (PST-Aid)
NCT06494384
Recruiting
Although evidence-based clinical interventions (CI) are a preferred treatment option for patients with depression, CIs are rarely available in community primary care settings. When available, CIs are often delivered with poor fidelity and abandoned by practitioners during the initial months post-training. Identifying effective implementation strategies to support the adoption, reach, and sustained use with fidelity of these CIs could enhance the effectiveness of primary care-based treatment of d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: OCHIN, Inc., Portland, Oregon
Conditions: Depression
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ICBT (Internet Based Cognitive Behavioral Therapy) for Maternal Depression: Community Implementation in Head Start
NCT05142384
Recruiting
Low income women of childbearing age are at increased risk for depression and often do not receive needed treatment. Investigators developed Mom-Net, an on-line cognitive behavioral treatment (CBT) for depression to address the needs of low income women of childbearing age. The intervention program also includes live coaching to help the mothers engage and learn the CBT material. Mom-Net has been shown to be highly effective in reducing depressive symptoms and improving parenting behavior and ch... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
02/04/2025
Locations: Oregon Research Institute, Springfield, Oregon
Conditions: Depression
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Apimostinel + Automated Neurocognitive Training for Depression
NCT06400121
Recruiting
Apimostinel shows initial promise as a novel rapid-acting antidepressant medication with minimal side effects or safety concerns. Cognitive Training (CT) is a digital intervention that has shown promise in extending the durability of another similar drug (ketamine). This randomized controlled trial will test the efficacy and safety of apimostinel (vs. placebo) for the acute treatment of depression, and will test the potential of CT to enhance and/or extend the durability of apimostinel's antidep... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/03/2025
Locations: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Conditions: Depression
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Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
NCT05136703
Recruiting
The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/02/2025
Locations: University of Miami Neuroimaging Facility, Coral Gables, Florida +1 locations
Conditions: Depression, HIV-1-infection, Inflammation
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PRISM for Depression and Anxiety in Young Adults with Cancer
NCT06502483
Recruiting
This research study is being done to test the feasibility of an existing supportive program (PRISM) to address psychological symptoms (i.e., depressive and anxiety symptoms) that young adult participants diagnosed with cancer or desmoid tumor may experience. The name of the intervention used in this research study is: -Promoting Resilience in Stress Management (PRISM) Program
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
01/29/2025
Locations: Dana-Farber Cancer Institute, Brighton, Massachusetts
Conditions: Cancer Diagnosis, Non-Metastatic Neoplasm, Anxiety, Anxiety Disorders, Depression, Depressive Disorder, Depression, Anxiety, Desmoid
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Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Disorders
NCT06502717
Recruiting
US residents who have mental health issues sign the informed consent form and are screened and enrolled for this study. Participants complete a survey upon enrollment and are randomized into one of two study arms. This study is direct to participant and will NOT utilize clinical sites.
Gender:
ALL
Ages:
Between 25 years and 75 years
Trial Updated:
01/27/2025
Locations: Viome Life Sciences, Bothell, Washington
Conditions: Mental Health Issue, Depression, Anxiety
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Factorial Optimization Trial to Test Effects of Coping Intervention Components
NCT05822687
Recruiting
This study will identify components for inclusion in a coping intervention package to reduce mental health problems among children exposed to high interparental conflict after parental separation/divorce. Reappraisal, distraction, and relaxation coping strategies are related to fewer mental health problems among children, making intervention components based on these strategies key candidates for inclusion in an optimized coping intervention. The primary aim is to experimentally assess the main... Read More
Gender:
ALL
Ages:
Between 9 years and 12 years
Trial Updated:
01/27/2025
Locations: Arizona State University, Tempe, Arizona
Conditions: Anxiety, Depression, Coping Skills, Emotional Problem
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Exercise Plus Duloxetine for Knee Osteoarthritis
NCT04111627
Recruiting
This study evaluates the addition of duloxetine to aerobic exercise in the treatment of symptomatic knee osteoarthritis and depressive symptoms in adults. All participants will receive the receive the treatment protocol, which will first be evaluated in terms of feasibility and then pilot tested.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
01/23/2025
Locations: University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Knee Osteoarthritis, Depression
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Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
NCT06162624
Recruiting
The goal of this research study is to adapt an ACT-self-help workbook to the prison setting and determine the feasibility acceptability, and effectiveness of this workbook. Participants can expect to be in the study for 13 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Anxiety, Depression, Depression, Anxiety, Anxiety Disorders
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External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy
NCT06788977
Recruiting
This online registry aims to understand the potential benefits and safety of external trigeminal nerve stimulation for the treatment of migraine in pregnant women. Women do not need to use external trigeminal nerve stimulation or any other form of migraine treatment to participate in the registry. The main question it aims to answer is: Is external trigeminal nerve stimulation a safe and effective option for migraine treatment during and after pregnancy? There are no required changes in migra... Read More
Gender:
FEMALE
Ages:
Between 18 years and 44 years
Trial Updated:
01/17/2025
Locations: https://public.smart-trial.co/#/public/649d77f0e8f8d0fb993d0c61/6626f6a04f0a3c7dd0860e14/662726d84f0a3c7dd08aeaa0/signup?lang=en-us&enforceLanguage=true, Darien, Connecticut
Conditions: Pregnancy, Migraine, Headache, Postpartum, Depression, Anxiety
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Dopaminergic Therapy for Anhedonia - 2
NCT06075771
Recruiting
The purpose of this 8-week, double-blind, placebo-controlled, study is to explore new treatment options for people with depression who have high inflammation and anhedonia. Seventy male and female participants with depression, between 25-55 years of age, with higher levels of inflammation and anhedonia will be randomized to receive L-DOPA or matched placebo over 8 weeks. Participants will complete lab tests, medical and psychiatric assessments, motivation and motor tasks, and MRI scans as part o... Read More
Gender:
ALL
Ages:
Between 25 years and 55 years
Trial Updated:
01/16/2025
Locations: Emory University Hospital, Atlanta, Georgia
Conditions: Anhedonia, Depression
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Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
NCT06273527
Recruiting
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as... Read More
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
01/15/2025
Locations: UC San Diego, San Diego, California
Conditions: Anxiety Disorders, Depression, Post Traumatic Stress Disorder
Register for Updates