There are currently 254 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Cerebellar Stimulation and Cognitive Control
NCT03217110
Recruiting
The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
01/09/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Schizophrenia, Autism Spectrum Disorder, Bipolar Disorder, Depression, Parkinson Disease
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Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
NCT06749288
Recruiting
A randomized, double-blind, placebo-controlled, direct-to-consumer trial assessing the impact of health and wellness products on hormonal health and associated health outcomes in women with menopausal health issues
Gender:
FEMALE
Ages:
Between 21 years and 105 years
Trial Updated:
01/07/2025
Locations: Radicle Science, Inc, Del Mar, California
Conditions: Menopause, Sleep Disturbance, Anxiety, Depression, Cognitive Function, Fatigue, Libido
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Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)
NCT06455527
Recruiting
This technology development project will be informed and guided by initial data collection of human subject data. For this purpose, the investigators will recruit n=100 people with mild to moderate depression in a double-blinded, parallel-arm, sham-controlled data collection period administered at home and using the investigator's remotely supervised (RS) tDCS protocol. Enrolled participants will complete 10 days of 30-minute tDCS (2.0, DLPFC left anodal) using the RS-tDCS protocol. During each... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/06/2025
Locations: NYU Langone Health, New York, New York
Conditions: Depression
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Amplitude Titration to Improve ECT Clinical Outcomes
NCT05699226
Recruiting
A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT: H1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode placement switch at V2). H2: Individualized amplitude arm will have improved cognitive outcomes (DKEFS-... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
01/03/2025
Locations: University of New Mexico Health Science Center, Albuquerque, New Mexico
Conditions: Depression, ECT, Cognitive Change
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VOICES Socials for Older Veterans With Depression
NCT06145334
Recruiting
VOICES Veterans Socials (VS) support Veterans in the community through weekly social groups. Veterans socials have the potential to improve social functioning, mental health symptoms, and create lasting social support. This project aims to evaluate and improve Veterans Socials to help older Veterans with depression by adapting materials, interviewing VS attendees, and collecting questionnaires. The goal is to improve the program based on the results for future use and research.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
12/20/2024
Locations: VA Bedford HealthCare System, Bedford, MA, Bedford, Massachusetts
Conditions: Depression, Loneliness, Isolation
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MOSAIC (MOthers' AdvocateS In the Community) for Pregnant Women and Mothers of Children Under 5 With Experience of Intimate Partner Violence
NCT05106361
Recruiting
The purpose of this R34 exploratory research proposal is to conduct formative work for a larger randomized controlled trial (RCT) evaluating the effectiveness of the "Mother AdvocateS In the Community (MOSAIC) Plus" intervention to reduce depressive and PTSD symptoms and prevent additional IPV among pregnant women and mothers with children under 5 experiencing IPV. The MOSAIC Plus intervention will integrate IPT principles and skills into the MOSAIC intervention in order to expand it to address... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: YWCA Flint, Flint, Michigan
Conditions: Intimate Partner Violence, Depression, Post Traumatic Stress Disorder
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CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
NCT05663034
Recruiting
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based treatment for insomnia (MBTI) in treating insomnia symptoms and ameliorating depressive symptoms in persons with mild to moderate TBI and comorbid Post-Traumatic Stress Symptoms (PTSS) and insomnia symptoms in a 360 patients. Participants will undergo as... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Intrepid Spirit Center - Eglin Air Force Base, Eglin Air Force Base, Florida +4 locations
Conditions: Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress, Sleep, Memory Impairment, Cognitive Behavioral Therapy, Concussion, Brain, Head Injury, Brain Injury Traumatic Mild
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Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
NCT05117255
Recruiting
This project is designed to determine if a computer-delivered cognitive-behavioral treatment can improve the otherwise poor alcohol use disorder treatment outcomes for individuals with a co-occurring anxiety disorder. In the past, the investigators showed that this treatment does improve outcomes for these individuals when delivered by a therapist. If the present work shows that the computer-delivered version is also effective, it would provide an inexpensive program with virtually unlimited sca... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/11/2024
Locations: Lodging Plus Program, Fairview Hospital, Minneapolis, Minnesota
Conditions: Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, Alcohol Use Disorder, Depression
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Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
NCT06523439
Recruiting
This is a single-site open-label clinical trial of the Stanford Accelerated Intermittent Neuromodulation Therapy (SAINT®) protocol. The goal of this clinical trial is to learn if a new form of transcranial magnetic stimulation (TMS)-known generally as accelerated intermittent theta burst stimulation (aiTBS) and specifically as SAINT®-is effective as a first-line therapy in treating adolescents aged 14-19 years-old in their first episode of depression who have not undergone a full course of depre... Read More
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
12/06/2024
Locations: Dell Medical School at University of Texas at Austin, Austin, Texas
Conditions: Major Depressive Disorder, Depression in Adolescence, Depression, Major Depressive Episode
Register for Updates
Depression, Aging, Stress and Heart Health Study
NCT05570721
Recruiting
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women. The menopausal transition or perimenopause is a period of vulnerability for both depression and CVD, making it a key time to study this critical public health issue. This research will preliminarily explore whether disruption in two novel stress pathways 1) the renin-angiotensin-aldosterone system (RAAS) and autonomic nervous system (ANS) and... Read More
Gender:
FEMALE
Ages:
Between 44 years and 55 years
Trial Updated:
12/04/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Menopause, Depression, Heart Disease in Women, Stress
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Perinatal Research on Improving Sleep and Mental Health
NCT05596318
Recruiting
The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep hygiene education (SHE) for preventing perinatal depression? 2. Is the effect of digital CBT-I on perinatal depression mediated through prenatal insomnia symptom improvement? 3. Is the effect of digital CBT-I on perinatal depression moderated by baseli... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Insomnia, Depression
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Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention
NCT05965310
Recruiting
The goal of this parallel arm prospective randomized control trial study is to compare outcomes in Anterior Cruciate Ligament Reconstruction (ACLR) Surgery patients after exposure to a virtual psychological intervention (VPI) versus standard care. The main question the investigators are asking is if virtual administration of psychological CBT modules will be an accessible and convenient vehicle to improve ACLR outcomes. Participants will be placed either into a treatment group receiving virtual... Read More
Gender:
ALL
Ages:
13 years and above
Trial Updated:
12/04/2024
Locations: Henry Ford Health System, Detroit, Michigan
Conditions: Depression, Anterior Cruciate Ligament Injuries, Mental Health Issue
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