There are currently 252 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II
NCT06867549
Recruiting
The investigators hypothesize that brief behavioral therapy and targeted propofol infusion in depressed geriatric patients will augment subsequent slow wave sleep and improve clinical and cognitive outcomes. The team will recruit 70 participants for a double-blinded placebo controlled randomized controlled trial. Two propofol infusions, 2-6 days apart, will be administered, targeting either a low propofol dose arm (minimal EEG slow waves, brain effect-site concentration 1-2 mcg/ml) or moderate d... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/07/2025
Locations: Washington University School of Medicine/Barnes-Jewish Hospital, Saint Louis, Missouri
Conditions: Depression
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Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression
NCT06263660
Recruiting
This study aims to determine whether a keto-like supplement relative to placebo results in functional brain changes during fMRI tasks evaluating positive and negative valence in individuals with moderate to severe depression. In this double-blind randomized placebo-controlled trial, 75 individuals with a Patient Health Questionnaire (PHQ-9) scale score ≥ 10 (MDD) will be enrolled to participate in an 8-week treatment study to obtain 60 completers. Participants will be randomized with a 1-1 ratio... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/03/2025
Locations: Laureate Institute for Brain Research, Tulsa, Oklahoma
Conditions: Depression
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The Student Wellness and Emotional Growth Resiliency (SWAG-R) Program
NCT06652503
Recruiting
The purpose of this research study is to provide a free 6-week, online psychological coaching program to NSU undergraduate students to help with anxiety, depression, and stress, while improving quality of life and healthy coping skills.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Nova Southeastern University, Fort Lauderdale, Florida
Conditions: Anxiety, Depression, Stress, Wellbeing, Quality of Life
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Transdiagnostic Cognitive Biomarkers
NCT04864080
Recruiting
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depres... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Pain, Depression
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Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care
NCT06019377
Recruiting
This study will deploy a scalable secondary prevention program that leverages existing foster youth transition services to improve mental health functioning and service use before and after exiting foster care. Our short-term objective is to remotely test a group intervention called Stronger Youth Networks and Coping (SYNC) that targets cognitive schemas influencing stress responses, including mental health help-seeking and service engagement, among foster youth with behavioral health risk. SYNC... Read More
Gender:
ALL
Ages:
Between 16 years and 20 years
Trial Updated:
02/25/2025
Locations: Portland State University, Portland, Oregon
Conditions: Adolescent Behavior, Psychosocial Functioning, Coping Behavior, Help-Seeking Behavior, Utilization, Health Care, Depression, Anxiety, Stress Disorders, Post-Traumatic, Emotion Regulation, Child Welfare
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Digital InteGrated Behavioral TreatmeNt for Comorbid ObesITy and DeprEssion Among Racial and Ethnic Adults Age 50 and Older
NCT06636058
Recruiting
The goal of this randomized clinical trial is to test the efficacy of a fully digital intervention, combining the Lumen problem-solving therapy virtual coach for depression management with the Diabetes Prevention Program video-based program for weight loss, among racial and ethnic minorities with comorbid depression and obesity. The study aims include: * Determine the efficacy of the vCare intervention at 6 months. Primary outcomes are weight and depression symptom checklist 20-item (SCL-20) sc... Read More
Gender:
ALL
Ages:
Between 50 years and 74 years
Trial Updated:
02/25/2025
Locations: Department of Medicine, Vitoux Program on Aging and Prevention, Chicago, Illinois +1 locations
Conditions: Obesity, Depression
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Examining the Effects of Estradiol on Neural and Molecular Response to Reward
NCT05282277
Recruiting
This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).
Gender:
FEMALE
Ages:
Between 45 years and 55 years
Trial Updated:
02/24/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Depression, Psychosis, Anhedonia
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Cannabis, Linked Emotions, and Adolescent Risk Study
NCT06576076
Recruiting
The goal of this study is to disentangle relationships between acute cannabis use and withdrawal on proximal depression and suicide risk and recovery in adolescents ages 12-18 years by incorporating time-varying patterns of substance use, mood, and SI. This project aims to guide the development of scalable, individualized, accessible, and affordable interventions aimed to reduce depression and suicide risk among adolescents.
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
02/21/2025
Locations: Massachusetts General Hopsital, Boston, Massachusetts
Conditions: Cannabis Use, Depression, Suicidal Ideation, Adolescent Behavior
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Sleep to Reduce Incident Depression Effectively in Peripartum
NCT06430333
Recruiting
Perinatal depression (PND) is the most common complication in pregnancy and postpartum, which increases risk for adverse perinatal outcomes such as preterm birth, maternal suicidal thoughts, and impaired mother-infant bonding. Insomnia often precedes PND cases and may serve as an entry point for interventions preventing PND. The proposed project is a large-scale clinical trial to test the effectiveness of a mindfulness-based sleep program designed for pregnant women to improve sleep and alleviat... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/20/2025
Locations: Henry Ford Medical Center, Novi, Michigan
Conditions: Insomnia, Depression
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Stress and Pain in People Living With HIV
NCT06784908
Recruiting
This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.
Gender:
ALL
Ages:
Between 18 years and 68 years
Trial Updated:
02/19/2025
Locations: The Yale Stress Center, New Haven, Connecticut
Conditions: HIV, Depression, Cannabis Use Disorder, Stress, Pain
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Conversations With Caregivers About Health and Appearance
NCT06843200
Recruiting
This clinical trial is evaluating the effects of a 2-hour, small group discussion with parents and caregivers of adolescents in Oregon. We will evaluate whether parents'/caregivers' experience reductions in their disordered eating symptoms, mood symptoms, and parent-child relationship quality, relative to parent/caregiver participants in the wait list control. We will also evaluate whether the children of these parents/caregivers experience improvements in their disordered eating and mood sympto... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
02/18/2025
Locations: University of Oregon, Eugene, Oregon
Conditions: Disordered Eating Behaviors, Depression, Feeding Behaviors, Parent-Child Relations
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Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
NCT05543083
Recruiting
The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or a combination of cognitive-behavioral therapy and exercise training groups, decreases stress, improves mood, increases physical activity and physical fitness, and decreases insulin resistance among teenagers at risk for diabetes.
Gender:
FEMALE
Ages:
Between 12 years and 17 years
Trial Updated:
02/17/2025
Locations: Children's Hospital Colorado, Aurora, Colorado +1 locations
Conditions: Insulin Resistance, Depression, Depressive Disorder, Mood Disorders, Mental Disorder in Adolescence, Hyperinsulinism, Glucose Metabolism Disorders, Metabolic Disease
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