There are currently 253 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Ketamine for the Treatment of Depression in Parkinson's Disease
NCT04944017
Recruiting
The main purpose of this study is to examine the efficacy and safety of a repeated dosing ketamine infusion paradigm compared to placebo in individuals with PD. A subset of participants in each arm will undergo baseline and post-treatment PET and fMRI scans, to examine whether changes in synaptic density and reorganization of functional networks underlie ketamine's putative antidepressant effects in PD.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/08/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Parkinson's Disease, Depression
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Mood and Thought Process Study
NCT05585775
Recruiting
The primary objective for this project is to test whether affective executive functioning is a mechanism of action of mindfulness-based cognitive therapy and Wellness for Wellbeing. The main questions it aims to answer are: 1. Test the effect of MBCT vs. Wellness for Wellbeing on affective inhibition (i.e., emotionally valenced inhibition as measured via the affective Go/No Go task) using an RCT. 2. Test the effect of MBCT vs. Wellness for Wellbeing on (a) affective updating and (b) affective s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Butler Hospital, Providence, Rhode Island
Conditions: Depression in Remission, Depressive Symptoms, Depression
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Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
NCT05682677
Recruiting
The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive PACT plus 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will occur at baseline, 2 weeks, 4 weeks, and 8 weeks. Researchers will compare the PACT+iTBS group to the PACT+sham iTBS group to s... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/01/2024
Locations: UCSD, La Jolla, California
Conditions: Depression, Mild Traumatic Brain Injury, Concussion, Brain
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Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
NCT06004115
Recruiting
This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders. In a double blind, placebo controlled crossover design, up to 65 individuals will be recruited who will have a diagnosis of major depressive disorder (MDD) and at least one anxiety disorder (AD) (AD-MDD group), up to 65 participants will have a diagnosis of MDD and no diag... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/30/2024
Locations: Laureate Institute for Brain Research, Tulsa, Oklahoma
Conditions: Depression, Anxiety, Fear, Depression, Anxiety and Fear, Anxiety Disorders, Anxious Depression
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IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)
NCT06582784
Recruiting
The purpose of this research study is to evaluate a mobile application (app) for depression treatment called "Moodivate" among cancer survivors. Moodivate was developed by our research team to assist with the treatment of depressed mood. Participants will be randomly assigned to either download the mobile app, "Moodivate", or not. Approximately 2/3 of participants enrolled will receive the mobile app and the remaining 1/3 will not. All participants will complete electronic questionnaire measur... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/28/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Depression, Depressive Symptoms, Cancer
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Early Life Stress and Depression: Molecular and Functional Imaging
NCT04713722
Recruiting
Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experiences (they are resilient). In spite of this, little is known about the neurobiological mechanisms related to childhood adversity, especially oxidative stress abnormalities in the brain. To fill this gap,... Read More
Gender:
FEMALE
Ages:
Between 20 years and 32 years
Trial Updated:
10/28/2024
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Depression, Trauma, Psychological
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Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care
NCT04877197
Recruiting
The purpose of this study is to demonstrate whether Behavioral Activation for depression delivered via home based telehealth (BA-HT) is effective in improving social and role functioning in Veterans recently discharged from Cardiovascular disease (CVD-related) inpatient care. Eligible participants will receive either (1) twelve sessions of BA-HT or (2) standard best practices post CVD hospitalization care. Study participants will be 132 Veterans discharged from the Ralph H. Johnson VA Medical C... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/25/2024
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Depression, Cardiovascular Diseases
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Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury
NCT05497115
Recruiting
The purpose of this study to learn about patients' experience with the Trauma Resilience and Recovery program (TRRP) and/or the enhanced care group.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
10/24/2024
Locations: George Washington University Hospital, Washington, Virginia
Conditions: Posttraumatic Stress Disorder, Depression
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Psilocybin in Chronic Low Back Pain and Depression
NCT06355414
Recruiting
This study seeks to provide insight on psilocybin's effects on mechanisms of chronic pain among patients with co-morbid chronic low back pain and depression (CLBP+D). Participants will receive either a single high-dose of psilocybin (25mg absolute dose) or methylphenidate (40mg absolute dose). Participants will be asked to complete assessments of pain, depressive symptoms, and more general questionnaires regarding the participants experiences during the experimental sessions and the associated... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
10/24/2024
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Chronic Low-back Pain, Depression
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Cognitive Behavioral and Faith Fellowship to Improve Thy Health
NCT06292637
Recruiting
Investigators will examine the efficacy of a faith-based depression intervention, in reducing symptoms of depression among African American adults in Wisconsin. Twelve church groups, each with 10 people (N=120) will be invited to participate. This intervention will be the first evidence-based, faith-based intervention designed for African Americans if validated.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Second Baptist Church, Madison, Wisconsin +1 locations
Conditions: Depression
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Efficacy of a Multi-level School Intervention for LGBTQ Youth
NCT05541406
Recruiting
Efficacy of a Multi-level School Intervention for LGBTQ Youth
Gender:
ALL
Ages:
Between 12 years and 20 years
Trial Updated:
10/23/2024
Locations: El Monte High School, El Monte, California +20 locations
Conditions: Depression, Anxiety, Post Traumatic Stress Disorder, Coping Behavior, Sexual Minority Stress, Suicidality, Substance Use, Bullying, Harassment
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Exploring Virtual Reality Adventure Training Exergaming
NCT05563805
Recruiting
The current project aims to design and implement an 8-week Virtual Reality Adventure Therapy Exergaming (V-RATE) intervention focused on women veterans. A randomized controlled trial using a repeated measure design with a 1-month follow-up assessment will be employed to examine effects on physical and mental health outcomes.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
10/23/2024
Locations: University of Texas at Arlington, Arlington, Texas
Conditions: Physical Activity, Sedentary Behavior, Depression, Cognitive Function, Post Traumatic Stress Disorder, Quality of Life, Anxiety
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