There are currently 252 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System
NCT06555172
Recruiting
This feasibility clinical trial aims to assess the feasibility of implementing a 1-month app-based meditation program with officers in the juvenile legal system and other professionals working directly with legal-involved youth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Anxiety, Depression, Burnout, Professional, Emotion Regulation
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ICBT (Internet Based Cognitive Behavioral Therapy) for Maternal Depression: Community Implementation in Head Start
NCT05142384
Recruiting
Low income women of childbearing age are at increased risk for depression and often do not receive needed treatment. Investigators developed Mom-Net, an on-line cognitive behavioral treatment (CBT) for depression to address the needs of low income women of childbearing age. The intervention program also includes live coaching to help the mothers engage and learn the CBT material. Mom-Net has been shown to be highly effective in reducing depressive symptoms and improving parenting behavior and ch... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
02/04/2025
Locations: Oregon Research Institute, Springfield, Oregon
Conditions: Depression
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Implementation of Problem-Solving Treatment in Community Health Centers (PST-Aid)
NCT06494384
Recruiting
Although evidence-based clinical interventions (CI) are a preferred treatment option for patients with depression, CIs are rarely available in community primary care settings. When available, CIs are often delivered with poor fidelity and abandoned by practitioners during the initial months post-training. Identifying effective implementation strategies to support the adoption, reach, and sustained use with fidelity of these CIs could enhance the effectiveness of primary care-based treatment of d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: OCHIN, Inc., Portland, Oregon
Conditions: Depression
Register for Updates
Apimostinel + Automated Neurocognitive Training for Depression
NCT06400121
Recruiting
Apimostinel shows initial promise as a novel rapid-acting antidepressant medication with minimal side effects or safety concerns. Cognitive Training (CT) is a digital intervention that has shown promise in extending the durability of another similar drug (ketamine). This randomized controlled trial will test the efficacy and safety of apimostinel (vs. placebo) for the acute treatment of depression, and will test the potential of CT to enhance and/or extend the durability of apimostinel's antidep... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/03/2025
Locations: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Conditions: Depression
Register for Updates
Factorial Optimization Trial to Test Effects of Coping Intervention Components
NCT05822687
Recruiting
This study will identify components for inclusion in a coping intervention package to reduce mental health problems among children exposed to high interparental conflict after parental separation/divorce. Reappraisal, distraction, and relaxation coping strategies are related to fewer mental health problems among children, making intervention components based on these strategies key candidates for inclusion in an optimized coping intervention. The primary aim is to experimentally assess the main... Read More
Gender:
ALL
Ages:
Between 9 years and 12 years
Trial Updated:
01/27/2025
Locations: Arizona State University, Tempe, Arizona
Conditions: Anxiety, Depression, Coping Skills, Emotional Problem
Register for Updates
Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Disorders
NCT06502717
Recruiting
US residents who have mental health issues sign the informed consent form and are screened and enrolled for this study. Participants complete a survey upon enrollment and are randomized into one of two study arms. This study is direct to participant and will NOT utilize clinical sites.
Gender:
ALL
Ages:
Between 25 years and 75 years
Trial Updated:
01/27/2025
Locations: Viome Life Sciences, Bothell, Washington
Conditions: Mental Health Issue, Depression, Anxiety
Register for Updates
External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy
NCT06788977
Recruiting
This online registry aims to understand the potential benefits and safety of external trigeminal nerve stimulation for the treatment of migraine in pregnant women. Women do not need to use external trigeminal nerve stimulation or any other form of migraine treatment to participate in the registry. The main question it aims to answer is: Is external trigeminal nerve stimulation a safe and effective option for migraine treatment during and after pregnancy? There are no required changes in migra... Read More
Gender:
FEMALE
Ages:
Between 18 years and 44 years
Trial Updated:
01/17/2025
Locations: https://public.smart-trial.co/#/public/649d77f0e8f8d0fb993d0c61/6626f6a04f0a3c7dd0860e14/662726d84f0a3c7dd08aeaa0/signup?lang=en-us&enforceLanguage=true, Darien, Connecticut
Conditions: Pregnancy, Migraine, Headache, Postpartum, Depression, Anxiety
Register for Updates
Dopaminergic Therapy for Anhedonia - 2
NCT06075771
Recruiting
The purpose of this 8-week, double-blind, placebo-controlled, study is to explore new treatment options for people with depression who have high inflammation and anhedonia. Seventy male and female participants with depression, between 25-55 years of age, with higher levels of inflammation and anhedonia will be randomized to receive L-DOPA or matched placebo over 8 weeks. Participants will complete lab tests, medical and psychiatric assessments, motivation and motor tasks, and MRI scans as part o... Read More
Gender:
ALL
Ages:
Between 25 years and 55 years
Trial Updated:
01/16/2025
Locations: Emory University Hospital, Atlanta, Georgia
Conditions: Anhedonia, Depression
Register for Updates
Latino Teen Depression Treatment Study
NCT05499182
Recruiting
Despite experiencing higher rates of depressive symptoms (Center for Disease Control and Prevention, 2020) and similar rates of Major Depressive Disorder (MDD; Substance Abuse and Mental Health Services Administration (SAMHSA), 2019), Latino adolescents in the U.S. are significantly less likely than their non-Latino White peers to receive treatment for MDD (SAMHSA, 2019). The purpose of this study is to identify a stakeholder-preferred implementation strategy that may improve psychotherapy atten... Read More
Gender:
ALL
Ages:
13 years and above
Trial Updated:
01/14/2025
Locations: Researchmatch.org, Nashville, Tennessee
Conditions: Depression
Register for Updates
Cerebellar Stimulation and Cognitive Control
NCT03217110
Recruiting
The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
01/09/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Schizophrenia, Autism Spectrum Disorder, Bipolar Disorder, Depression, Parkinson Disease
Register for Updates
Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)
NCT06455527
Recruiting
This technology development project will be informed and guided by initial data collection of human subject data. For this purpose, the investigators will recruit n=100 people with mild to moderate depression in a double-blinded, parallel-arm, sham-controlled data collection period administered at home and using the investigator's remotely supervised (RS) tDCS protocol. Enrolled participants will complete 10 days of 30-minute tDCS (2.0, DLPFC left anodal) using the RS-tDCS protocol. During each... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/06/2025
Locations: NYU Langone Health, New York, New York
Conditions: Depression
Register for Updates
Amplitude Titration to Improve ECT Clinical Outcomes
NCT05699226
Recruiting
A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT: H1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode placement switch at V2). H2: Individualized amplitude arm will have improved cognitive outcomes (DKEFS-... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
01/03/2025
Locations: University of New Mexico Health Science Center, Albuquerque, New Mexico
Conditions: Depression, ECT, Cognitive Change
Register for Updates