There are currently 257 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Diet and Depression
NCT06252701
Recruiting
This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of UPF.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/30/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Depression, Major Depressive Disorder, Weight Gain, Obesity, Metabolic Syndrome
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FMRI Accelerated TMS Depression
NCT06562153
Recruiting
This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerated antidepressant transcranial magnetic stimulation (TMS) treatment.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/26/2024
Locations: 30 Bee Street, Charleston, South Carolina
Conditions: Depression
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Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
NCT06085937
Recruiting
There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/25/2024
Locations: University of Kansas Strawberry Hill Campus, Kansas City, Kansas +1 locations
Conditions: Suicide, Suicidal Ideation, Depression
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Self-Compassion for Children and Caregivers
NCT05818397
Recruiting
The Self-Compassion for Children and Caregivers Study aims to understand if an online course designed to help kids and their caregivers learn self-compassion is feasible, enjoyable, and helpful for well-being and relationships in families from diverse backgrounds. Children ages 8-11 who have a caregiver willing to participate with them will: * Attend 2 in-person study visits (about 1-1.5 hour each) that includes * A survey for caregiver and child * A brief computer puzzle challengetask whi... Read More
Gender:
ALL
Ages:
Between 8 years and 11 years
Trial Updated:
09/24/2024
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Anxiety, Depression
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Resilience in Adolescent Development
NCT03458936
Recruiting
The RAD study is a longitudinal study to prospectively characterize the biological mechanisms of resilience in adolescents and young adults at risk for developing depression. The study will capture biomarkers from the domains of socio-demographic and clinical data, cognitive and psychological assessments, fluid-based biomarkers, neuroimaging and EEG. Such biomarkers will compose a human biosignature of resilience and identify risk factors for depression, contributing to effective treatment selec... Read More
Gender:
ALL
Ages:
Between 10 years and 24 years
Trial Updated:
09/20/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Risk Assessment, Resilience, Psychological, Depression, Mood Disorders, Anxiety Disorders
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Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation
NCT06039930
Recruiting
The purpose of this randomized trial is to conduct a fully powered effectiveness trial of video-delivered PROTECT (Tele-PROTECT) compared to a video-delivered depression education (DepEd) control condition to be delivered to 140 English- and Spanish-speaking NYC elder abuse victims. Investigators hypothesize three main aims: 1. Effectiveness Aim: Tele-PROTECT participants will have significantly greater and clinically meaningful reductions in depression when compared to the DepEd control; 2. Ab... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
09/19/2024
Locations: Weill Cornell Medicine, New York, New York
Conditions: Depression, Elder Abuse
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Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study
NCT06595251
Recruiting
The Fit2Play prospective cohort study examines the effects of a park-based youth physical activity afterschool program on youth participant fitness and mental health outcomes. Duke will perform a secondary analysis of the data collected as part of the Fit2Play prospective cohort study run by Miami-Dade County Parks and Recreation.
Gender:
ALL
Ages:
Between 6 years and 14 years
Trial Updated:
09/17/2024
Locations: Miami-Dade County Parks, Recreation and Open Spaces Department, Miami, Florida
Conditions: Overweight, Obesity, Hypertension, Prehypertension, Anxiety, Well-being, Depression, Low Physical Fitness, Psychological
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A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression
NCT06570369
Recruiting
The main goal of this clinical trial is to learn if the active study drug (code name: SP-624) has any effect on the electrical activity of the brain in adult healthy volunteers and in adults with major depression. Another goal of the study is to learn if SP-624 improves memory and learning in adults with major depression. The study will also provide additional information on the safety of SP-624 and how well it is tolerated in adult healthy volunteers and adults with major depression. Researche... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
09/17/2024
Locations: Alivation Research, Lincoln, Nebraska
Conditions: Major Depressive Disorder, Depression, Healthy
Register for Updates
Treatment of Depression Post-SCI
NCT04263285
Recruiting
Depression is more common after a spinal cord injury (SCI) than in the general population. Unfortunately, it is unknown how depression is typically treated in individuals with SCI or if commonly used treatment methods are effective. This study will investigate the safety and impact of a novel method for treating depression called repetitive transcranial magnetic stimulation (rTMS). rTMS is a type of non-invasive brain stimulation. Fourteen individuals with a cervical or thoracic level SCI and de... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/04/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Depression, Spinal Cord Injuries
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Aging and Reward System Response to Inflammation and Anxiety Study
NCT05363527
Recruiting
The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation. Loss of pleasure or loss of motivation will be evaluated using self-report questionnaires, computer tasks, and during a brain scan.
Gender:
ALL
Ages:
Between 60 years and 80 years
Trial Updated:
09/04/2024
Locations: Norman Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, California
Conditions: Anhedonia, Inflammation, Anxiety, Aging, Depression
Register for Updates
Individualized (fMRI-guided) TMS Treatment for Depression
NCT06266390
Recruiting
The purpose of this study is to investigate the responses of the brain region known as the subgenual anterior cingulate cortex (sgACC) during transcranial magnetic stimulation (TMS) in individuals with depression. Specifically, investigators aim to determine whether the sgACC is engaged when TMS is delivered to specific targets and if the engagement of sgACC changes throughout a full TMS treatment intervention. To achieve this goal, the investigators will employ a combination of TMS and Magnetic... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/30/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Depression, Major Depressive Disorder, Persistent Depressive Disorder
Register for Updates
Suicide Specific Rumination in Veterans
NCT06481033
Recruiting
Few treatments target core features of suicidal thoughts and behaviors in Veterans. Real-time functional magnetic resonance imaging neurofeedback can provide information regarding brain activation associated with suicide-specific rumination, defined as a "repetitive mental fixation on one's suicidal thoughts and intentions." The goal of this feasibility study is for Veterans to learn strategies for modulating activity within brain regions that have been demonstrated to contribute to the maintena... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/28/2024
Locations: James J. Peters VA Medical Center, Bronx, NY, Bronx, New York
Conditions: Depression, Suicide, Mood Disorders
Register for Updates