There are currently 253 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Safe Mothers, Safe Children Initiative
NCT04752618
Recruiting
The purpose of this study is to assess the efficacy of the combined interventions, Skills Training in Affective and Interpersonal Regulation (STAIR) and Parent-Child Interaction Therapy (PCIT) or P-STAIR, for treating maternal PTSD and reducing maltreatment recidivism.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: McSilver Institute for Poverty Policy and Research, New York, New York
Conditions: PTSD, Depression, Child Maltreatment
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WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt
NCT05183230
Recruiting
The goal of this project is to test whether WellPATH-PREVENT (a novel, mobile psychosocial intervention) improves a specific aspect of emotion regulation, i.e., cognitive reappraisal ability, and reduces suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a suicide-related hospitalization (i.e. for suicidal ideation or suicide attempt).
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
11/22/2024
Locations: New York Presbyterian Hospital/Weill Cornell Medicine, New York, New York +1 locations
Conditions: Suicide, Attempted, Suicidal Ideation, Depression
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Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches
NCT05176392
Recruiting
This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide marked reduction in mTBI related headaches and symptoms in comparison to their placebo counterparts.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/18/2024
Locations: VA San Diego Healthcare System, San Diego, California
Conditions: TBI (Traumatic Brain Injury), Headache, Depression
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Brief Interventions for Coping with Distress
NCT05779761
Recruiting
This study is being done to compare the effectiveness of three different skills trainings to cope with distress. These three trainings are: 1) an attention skills training, 2) an attention and reflective thought skills training, and 3) a health and wellness education training.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/18/2024
Locations: Teachers College, Columbia University, New York, New York
Conditions: Distress, Emotional, Emotional Dysfunction, Anxiety, Depression
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Brain Stimulation and Decision-making
NCT04099056
Recruiting
Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in this process, it remains unclear exactly how these regions are influencing choice behavior especially when choices become more challenging. The goal of this project is to understand how these regions, such as the cingulate cortex, impact difficult choice behavior. Specifically, the researchers are i... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/14/2024
Locations: Emory University, Atlanta, Georgia
Conditions: Depression
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Study on Allopregnanolone and Depression in Women Across the Menopause Transition
NCT06238700
Recruiting
This study aims to identify how enhanced allopregnanolone activity (via pregnenolone) affects behavior and neurobiology that may underlie perimenopausal depression.
Gender:
FEMALE
Ages:
Between 40 years and 60 years
Trial Updated:
11/13/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Depression
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Families With Pride ("Familias Con Orgullo").
NCT06057337
Recruiting
This study will evaluate the effects of a parenting intervention for Hispanic sexual minority youth in preventing/reducing drug use and depressive symptoms. It will also examine whether the intervention improves parent social support for the adolescent, parent acceptance, family functioning, and whether it reduces general stress and stress associated with being a Hispanic sexual minority.
Gender:
ALL
Ages:
Between 13 years and 19 years
Trial Updated:
11/12/2024
Locations: University of Miami, Coral Gables, Florida
Conditions: Depression, Drug Use
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Cold and Heat Investigation to Lower Levels of Depression
NCT06263738
Recruiting
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water plunge. Participants will complete a baseline assessment of their depressive symptoms as well as 1-week and 2-week post-treatment followup assessments.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/11/2024
Locations: Vail Health Behavioral Health Innovation Center, Edwards, Colorado
Conditions: Depression, Mood Disorders
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Ketamine for the Treatment of Depression in Parkinson's Disease
NCT04944017
Recruiting
The main purpose of this study is to examine the efficacy and safety of a repeated dosing ketamine infusion paradigm compared to placebo in individuals with PD. A subset of participants in each arm will undergo baseline and post-treatment PET and fMRI scans, to examine whether changes in synaptic density and reorganization of functional networks underlie ketamine's putative antidepressant effects in PD.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/08/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Parkinson's Disease, Depression
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Mood and Thought Process Study
NCT05585775
Recruiting
The primary objective for this project is to test whether affective executive functioning is a mechanism of action of mindfulness-based cognitive therapy and Wellness for Wellbeing. The main questions it aims to answer are: 1. Test the effect of MBCT vs. Wellness for Wellbeing on affective inhibition (i.e., emotionally valenced inhibition as measured via the affective Go/No Go task) using an RCT. 2. Test the effect of MBCT vs. Wellness for Wellbeing on (a) affective updating and (b) affective s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Butler Hospital, Providence, Rhode Island
Conditions: Depression in Remission, Depressive Symptoms, Depression
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Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
NCT05682677
Recruiting
The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive PACT plus 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will occur at baseline, 2 weeks, 4 weeks, and 8 weeks. Researchers will compare the PACT+iTBS group to the PACT+sham iTBS group to s... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/01/2024
Locations: UCSD, La Jolla, California
Conditions: Depression, Mild Traumatic Brain Injury, Concussion, Brain
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Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
NCT06004115
Recruiting
This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders. In a double blind, placebo controlled crossover design, up to 65 individuals will be recruited who will have a diagnosis of major depressive disorder (MDD) and at least one anxiety disorder (AD) (AD-MDD group), up to 65 participants will have a diagnosis of MDD and no diag... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/30/2024
Locations: Laureate Institute for Brain Research, Tulsa, Oklahoma
Conditions: Depression, Anxiety, Fear, Depression, Anxiety and Fear, Anxiety Disorders, Anxious Depression
Register for Updates