There are currently 255 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy
NCT05908565
Recruiting
The goal is to optimize peer coaching in order to optimize engagement and outcomes in digital therapy. The unmet mental health needs of community college students are staggering and a growing body of research demonstrates that therapy provided digitally with the assistance of trained community members without advanced degrees in mental health is an effective and scalable way to address these needs. Despite being effective for improving symptoms and functioning in those who engage in it, uptake a... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/23/2024
Locations: East Los Angeles College, Los Angeles, California
Conditions: Depression, Anxiety
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Storytelling and Mindfulness for Graduate Student Wellbeing
NCT05826860
Recruiting
The purpose of this study is to evaluate an intervention for improving Science, Technology, Engineering, and Math (STEM) graduate student wellbeing. Participants will be recruited from the University of Wisconsin-Madison graduate student body. Data will be collected from participants for up to 2 years, and the investigators anticipate that the study will last for 4 years.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2024
Locations: Wisconsin Institute for Discovery, Madison, Wisconsin
Conditions: Depression, Anxiety, Burnout, Student
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To Improve Depressive Symptoms Using a Web-App
NCT05405803
Recruiting
This study is being done to answer a question on whether a Web App-based Lifestyle Physical Activity Promotion Program is effective in improving depressive symptom experience of midlife Korean American women (WPAPP-K).
Gender:
FEMALE
Ages:
Between 40 years and 60 years
Trial Updated:
07/17/2024
Locations: The University of Texas at Austin, Austin, Texas
Conditions: Depression
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Treatment, Emotion, and Neuromodulation of Depression (TREND) Study
NCT05436379
Recruiting
The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.
Gender:
ALL
Ages:
Between 18 years and 26 years
Trial Updated:
07/17/2024
Locations: The University of Pittsburgh, Department of Psychiatry, Pittsburgh, Pennsylvania
Conditions: Depression
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The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity
NCT04953806
Recruiting
Chronic Obstructive Pulmonary Disease (COPD) is prevalent and debilitating chronic disease in Veterans. COPD is highly co-morbid with depression and anxiety conferring greater morbidity and mortality risk. Physical activity is a modifiable behavior that can improve COPD outcomes. However, to date, interventions targeting physical activity have not addressed the high comorbidity between COPD and depression and/or anxiety symptoms ("emotional distress") despite emotional distress predicting poorer... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/16/2024
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: COPD, Depression, Anxiety
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Assessing an EEG Biomarker of Response to TMS for Major Depression
NCT05008198
Recruiting
Veterans with treatment resistant depression (TRD) have the opportunity to receive transcranial magnetic stimulation (TMS) treatment via the VA's National TMS Clinical Pilot Program. While some see improvement with their depression, others do not. Therefore, it may be beneficial to be able to predict with biomarkers what participants may see improvement with their treatment. Electroencephalography (EEG) is a means to identify such biomarkers. Four hundred Veterans with TRD will be enrolled in th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2024
Locations: White River Junction VA Medical Center, White River Junction, VT, White River Junction, Vermont
Conditions: Depression
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Cognitive Enhancement in Depression (The COG-D Study)
NCT05400512
Recruiting
This study will investigate whether transcranial direct current stimulation (tDCS) enhances the effects of computerized cognitive training in older adults with recurrent depression (2 or more lifetime episodes; either current or within past 3 years).
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/08/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Aging, Depression, Cognitive Symptom
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taVNS or TMS or Both for Depression
NCT05725239
Recruiting
The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) and transcranial (through the skull) magnetic stimulation (TMS). For participants who already have a cervical VNS device, the investigators will not change their treatment and will use this in place of... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/02/2024
Locations: Medical University of South Carolina Institute of Psychiatry, Charleston, South Carolina
Conditions: Depression
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Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
NCT04276259
Recruiting
The central goal of this application is to demonstrate the causal contribution of reward learning signals (expected values and reward prediction errors \[RPE\]) to antidepressant responses (Aim1) by experimentally manipulating expected values using transcranial magnetic stimulation (TMS) targeting the vmPFC (Aim 2) and μ-opioid striatal RPE signal using pharmacological approaches (Aim 3).
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/01/2024
Locations: Bellefield Tower, Pittsburgh, Pennsylvania
Conditions: Major Depressive Disorder, Depression
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Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults
NCT06060860
Recruiting
Autistic adults are at a greater risk for mental health problems compared to the general population, with 50% meeting criteria for a co-occurring psychiatric condition. Depression and anxiety are the most common of these conditions among autistic adults, contributing to long-term detrimental effects on health, day-to-day functioning, and quality of life. This study will conduct the first large-scale head-to-head comparison of the two most widely studied mental health interventions for autistic a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina +1 locations
Conditions: Autism Spectrum Disorder, Depression, Anxiety
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Telehealth Behavioral Activation for Teens
NCT06273995
Recruiting
Behavioral activation is one such empirically supported intervention. Derived from cognitive-behavioral therapy, a well-established treatment for depression, behavioral activation uses psychoeducation and skill-building to increase an individual's engagement in valued and enjoyable activities (e.g., socializing with family and friends, exercising, participating in a hobby) in order to improve depressive symptoms. Research has shown that behavioral activation is an effective intervention for depr... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
06/20/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Depression, Suicide and Self-harm, Depression in Adolescence, Depression Mild, Depression Moderate, Depression Severe
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Mindfulness Engaged Neurostimulation for Depression
NCT06399406
Recruiting
Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of \~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermitten... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/20/2024
Locations: University of California San Diego, La Jolla, California
Conditions: Depression, Treatment Resistant Depression, Major Depressive Disorder, Depressive Disorder
Register for Updates