There are currently 252 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
NCT06523439
Recruiting
This is a single-site open-label clinical trial of the Stanford Accelerated Intermittent Neuromodulation Therapy (SAINT®) protocol. The goal of this clinical trial is to learn if a new form of transcranial magnetic stimulation (TMS)-known generally as accelerated intermittent theta burst stimulation (aiTBS) and specifically as SAINT®-is effective as a first-line therapy in treating adolescents aged 14-19 years-old in their first episode of depression who have not undergone a full course of depre... Read More
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
12/06/2024
Locations: Dell Medical School at University of Texas at Austin, Austin, Texas
Conditions: Major Depressive Disorder, Depression in Adolescence, Depression, Major Depressive Episode
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Depression, Aging, Stress and Heart Health Study
NCT05570721
Recruiting
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women. The menopausal transition or perimenopause is a period of vulnerability for both depression and CVD, making it a key time to study this critical public health issue. This research will preliminarily explore whether disruption in two novel stress pathways 1) the renin-angiotensin-aldosterone system (RAAS) and autonomic nervous system (ANS) and... Read More
Gender:
FEMALE
Ages:
Between 44 years and 55 years
Trial Updated:
12/04/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Menopause, Depression, Heart Disease in Women, Stress
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Perinatal Research on Improving Sleep and Mental Health
NCT05596318
Recruiting
The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep hygiene education (SHE) for preventing perinatal depression? 2. Is the effect of digital CBT-I on perinatal depression mediated through prenatal insomnia symptom improvement? 3. Is the effect of digital CBT-I on perinatal depression moderated by baseli... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Insomnia, Depression
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Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention
NCT05965310
Recruiting
The goal of this parallel arm prospective randomized control trial study is to compare outcomes in Anterior Cruciate Ligament Reconstruction (ACLR) Surgery patients after exposure to a virtual psychological intervention (VPI) versus standard care. The main question the investigators are asking is if virtual administration of psychological CBT modules will be an accessible and convenient vehicle to improve ACLR outcomes. Participants will be placed either into a treatment group receiving virtual... Read More
Gender:
ALL
Ages:
13 years and above
Trial Updated:
12/04/2024
Locations: Henry Ford Health System, Detroit, Michigan
Conditions: Depression, Anterior Cruciate Ligament Injuries, Mental Health Issue
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Mood Lifters for Undergraduates
NCT05684120
Recruiting
Large-scale, effective, low-cost, and evidence-based programs that can nimbly translate new research discoveries into prevention and care for psychosocial-based problems are urgently needed since the vast majority of people who need evidence-based care do not receive it. The purpose of this randomized control trial is to investigate the feasibility and efficacy of a Mood Lifters group template specifically for undergraduate students. Mood Lifters is an effective peer-led program that improves o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Depression, Anxiety, Mood Disorders, Mental Health Wellness 1, Stress
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Safe Mothers, Safe Children Initiative
NCT04752618
Recruiting
The purpose of this study is to assess the efficacy of the combined interventions, Skills Training in Affective and Interpersonal Regulation (STAIR) and Parent-Child Interaction Therapy (PCIT) or P-STAIR, for treating maternal PTSD and reducing maltreatment recidivism.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: McSilver Institute for Poverty Policy and Research, New York, New York
Conditions: PTSD, Depression, Child Maltreatment
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WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt
NCT05183230
Recruiting
The goal of this project is to test whether WellPATH-PREVENT (a novel, mobile psychosocial intervention) improves a specific aspect of emotion regulation, i.e., cognitive reappraisal ability, and reduces suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a suicide-related hospitalization (i.e. for suicidal ideation or suicide attempt).
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
11/22/2024
Locations: New York Presbyterian Hospital/Weill Cornell Medicine, New York, New York +1 locations
Conditions: Suicide, Attempted, Suicidal Ideation, Depression
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Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches
NCT05176392
Recruiting
This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide marked reduction in mTBI related headaches and symptoms in comparison to their placebo counterparts.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/18/2024
Locations: VA San Diego Healthcare System, San Diego, California
Conditions: TBI (Traumatic Brain Injury), Headache, Depression
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Brief Interventions for Coping with Distress
NCT05779761
Recruiting
This study is being done to compare the effectiveness of three different skills trainings to cope with distress. These three trainings are: 1) an attention skills training, 2) an attention and reflective thought skills training, and 3) a health and wellness education training.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/18/2024
Locations: Teachers College, Columbia University, New York, New York
Conditions: Distress, Emotional, Emotional Dysfunction, Anxiety, Depression
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Brain Stimulation and Decision-making
NCT04099056
Recruiting
Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in this process, it remains unclear exactly how these regions are influencing choice behavior especially when choices become more challenging. The goal of this project is to understand how these regions, such as the cingulate cortex, impact difficult choice behavior. Specifically, the researchers are i... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/14/2024
Locations: Emory University, Atlanta, Georgia
Conditions: Depression
Register for Updates
Study on Allopregnanolone and Depression in Women Across the Menopause Transition
NCT06238700
Recruiting
This study aims to identify how enhanced allopregnanolone activity (via pregnenolone) affects behavior and neurobiology that may underlie perimenopausal depression.
Gender:
FEMALE
Ages:
Between 40 years and 60 years
Trial Updated:
11/13/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Depression
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Families With Pride ("Familias Con Orgullo").
NCT06057337
Recruiting
This study will evaluate the effects of a parenting intervention for Hispanic sexual minority youth in preventing/reducing drug use and depressive symptoms. It will also examine whether the intervention improves parent social support for the adolescent, parent acceptance, family functioning, and whether it reduces general stress and stress associated with being a Hispanic sexual minority.
Gender:
ALL
Ages:
Between 13 years and 19 years
Trial Updated:
11/12/2024
Locations: University of Miami, Coral Gables, Florida
Conditions: Depression, Drug Use
Register for Updates