There are currently 281 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Using a Smartphone App to Target Current Mental Health Symptoms of Anxiety and Depression
NCT06037382
Recruiting
This is a prevention intervention study that will examine the efficacy of a smartphone-based intervention in decreasing cancer risk by targeting mental health risk factors of anxiety and depression.
Gender:
All
Ages:
Between 40 years and 64 years
Trial Updated:
10/27/2023
Locations: Dartmouth College, Hanover, New Hampshire
Conditions: Depression, Anxiety, Cancer
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Brain Stimulation and Decision-making
NCT04099056
Recruiting
Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in this process, it remains unclear exactly how these regions are influencing choice behavior especially when choices become more challenging. The goal of this project is to understand how these regions, such as the cingulate cortex, impact difficult choice behavior. Specifically, the researchers are i... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
10/26/2023
Locations: Emory University, Atlanta, Georgia
Conditions: Depression
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Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
NCT06069843
Recruiting
Ketamine is a NMDA-receptor antagonist that promotes synapse formation and has been shown to rapidly improve symptoms in depression. Even a single dose of ketamine has been shown to improve depression and cognition with short-term memory, inhibitory control, cognitive flexibility, and processing speed showing improvements within days of treatment. The mechanism behind ketamine's rapid action is not clear but some groups have speculated it may be related to enhanced neuroplasticity, particularly... Read More
Gender:
All
Ages:
Between 50 years and 90 years
Trial Updated:
10/23/2023
Locations: Icahn School of Medicine at Mount Sinai (Depression and Anxiety Center), New York, New York
Conditions: Depression, Mild Cognitive Impairment
Register for Updates
Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation
NCT06039930
Recruiting
The purpose of this randomized trial is to conduct a fully powered effectiveness trial of video-delivered PROTECT (Tele-PROTECT) compared to a video-delivered depression education (DepEd) control condition to be delivered to 140 English- and Spanish-speaking NYC elder abuse victims. Investigators hypothesize three main aims: Effectiveness Aim: Tele-PROTECT participants will have significantly greater and clinically meaningful reductions in depression when compared to the DepEd control; Abuse Im... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
10/19/2023
Locations: Weill Cornell Medicine, New York, New York
Conditions: Depression, Elder Abuse
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Improving Brain Stimulation Through Imaging
NCT03851380
Recruiting
Repetitive pulse transcranial magnetic stimulation (rTMS) is a noninvasive treatment that involves stimulating the brain; however, treatment benefit depends on placing a TMS coil in the correct place on the head to reach critical brain regions below. Clinicians typically use scalp-based targeting, a process in which rather than using MRI guidance to target brain regions for stimulation, they use landmarks on the scalp. Several researchers, including the investigators' lab, showed that the curren... Read More
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
10/18/2023
Locations: VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California
Conditions: Depression, Depressive Disorder, Treatment-Resistant, COVID Stress
Register for Updates
Strengthening Community Mental Health
NCT06093737
Recruiting
The goal of this clinical trial is to examine the impact of the Communities Organizing for Power through Empathy (COPE) intervention in adults in communities having recently experienced or at risk of experiencing disaster. The main questions it aims to answer are: How does the COPE intervention affect individual mental health? How does the COPE intervention affect protective factors like coping and social support? How does the COPE intervention affect community resilience? How does delivery of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/17/2023
Locations: Together Baton Rouge, Baton Rouge, Louisiana
Conditions: Mental Health, Emotional Wellbeing, Anxiety, Depression, Stress, Coping, Perceived Stress, Perceived Social Support
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Resilience in Adolescent Development
NCT03458936
Recruiting
The RAD study is a longitudinal study to prospectively characterize the biological mechanisms of resilience in adolescents and young adults at risk for developing depression. The study will capture biomarkers from the domains of socio-demographic and clinical data, cognitive and psychological assessments, fluid-based biomarkers, neuroimaging and EEG. Such biomarkers will compose a human biosignature of resilience and identify risk factors for depression, contributing to effective treatment selec... Read More
Gender:
All
Ages:
Between 10 years and 24 years
Trial Updated:
10/12/2023
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Risk Assessment, Resilience, Psychological, Depression, Mood Disorders, Anxiety Disorders
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Mindful Moms Randomized Control Trial
NCT04886856
Recruiting
The purpose of this study is to test whether a program called "Mindful Moms" can be helpful for specific measures of mood and health in pregnant women with depressive symptoms, compared to group-based education workshops.
Gender:
Female
Ages:
18 years and above
Trial Updated:
10/10/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Depression
Register for Updates
Computational Psychiatric Approach to Depression
NCT04189939
Recruiting
The purpose of this research is to investigate how the brain changes in patients undergoing electroconvulsive (ECT) treatment for depression. Subjects will be invited to be in this study because (1) they are a patient about to receive ECT treatment for depression, or (2) they are a patient diagnosed with depression and do not qualify for ECT treatment, or (3) they are a healthy adult volunteer with no history of depression. All volunteers must be between the ages of 18-85. Participation in this... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/09/2023
Locations: Wake Forest School of Medicine, Winston-Salem, North Carolina
Conditions: Depression, Treatment Resistant Depression
Register for Updates
Efficacy of a Multi-level School Intervention for LGBTQ Youth
NCT05541406
Recruiting
Efficacy of a Multi-level School Intervention for LGBTQ Youth
Gender:
All
Ages:
Between 12 years and 20 years
Trial Updated:
10/06/2023
Locations: El Monte High School, El Monte, California +17 locations
Conditions: Depression, Anxiety, Post Traumatic Stress Disorder, Coping Behavior, Sexual Minority Stress, Suicidality, Substance Use, Bullying, Harassment
Register for Updates
Collaborative Care for Anxiety and Depression in Epilepsy
NCT05559749
Recruiting
This is a randomized effectiveness/implementation trial comparing a 24-week neurology-based collaborative care intervention to usual neurology care among 60 adults with epilepsy.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/03/2023
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Epilepsy, Anxiety, Depression
Register for Updates
Exploring Virtual Reality Adventure Training Exergaming
NCT05563805
Recruiting
The current project aims to design and implement an 8-week Virtual Reality Adventure Therapy Exergaming (V-RATE) intervention focused on women veterans. A randomized controlled trial using a repeated measure design with a 1-month follow-up assessment will be employed to examine effects on physical and mental health outcomes.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
10/02/2023
Locations: University of Texas at Arlington, Arlington, Texas
Conditions: Physical Activity, Sedentary Behavior, Depression, Cognitive Function, Post Traumatic Stress Disorder, Quality of Life, Heart Rate Variability, Anxiety
Register for Updates