There are currently 268 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
Mindfulness Engaged Neurostimulation for Depression
NCT06399406
Recruiting
Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of ~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermittent... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
06/20/2024
Locations: University of California San Diego, La Jolla, California
Conditions: Depression, Treatment Resistant Depression, Major Depressive Disorder, Depressive Disorder
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The Nuestros Días ("Our Days") Study
NCT06475534
Recruiting
The goal of this observational study is to understand how contextual, individual-level, and cultural factors influence the daily and long-term well-being of caregivers of relatives with memory problems or dementia. The study focuses on caregivers from the Hispanic and Latino community. The main questions it aims to answer are: * What daily factors increase (i.e., risk factors) or decrease (i.e., protective factors) the daily odds of depression and anxiety symptoms reported by caregivers? * How... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/20/2024
Locations: The University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Caregiver Burden, Well-Being, Psychological, Stress, Psychological, Depression, Anxiety
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Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families
NCT06261463
Recruiting
The proposed study draws on prior research to evaluate the feasibility, acceptability and explore preliminary effectiveness of Coffee and Family Education and Support, Version (CAFES2) using a pilot randomized type 1 hybrid effectiveness-implementation design. CAFES2 is a peer-led family and social strengthening multiple family group intervention that is designed to respond to multi-level needs of refugee families. Results of the trial will contribute to the emerging evidence base on family-base... Read More
Gender:
All
Ages:
Between 12 years and 45 years
Trial Updated:
06/12/2024
Locations: University of Illinios Chicago, Chicago, Illinois
Conditions: Depression, Anxiety, PTSD, Family Dynamics, Social Functioning, Family Support, Family Relations
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A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
NCT05081596
Recruiting
The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care.
Gender:
All
Ages:
60 years and above
Trial Updated:
06/11/2024
Locations: Weill Cornell Medicine, White Plains, New York
Conditions: Depression, Pain, Cognitive Impairment
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Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior
NCT05652153
Recruiting
The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measure negative urgency and brain signals in adolescents aged 13-21 years with depression and suicidal thoughts and behaviors. The main questions it aims to answer are: Whether a type of brain signaling c... Read More
Gender:
All
Ages:
Between 13 years and 21 years
Trial Updated:
06/10/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Suicidal Behavior, Suicidal Ideation, Negative Urgency, Cortical Inhibition, Depression
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Depression & Insulin Sensitivity in Adolescents
NCT03263351
Recruiting
There has been a rise in type 2 diabetes (T2D) rates in adolescents, disproportionately in girls from disadvantaged racial/ethnic groups. This group of girls also is at heightened risk for depression, and depression and T2D are linked. Depressive symptoms are a risk factor for worsening of insulin sensitivity, one if the major precursors to T2D. In preliminary studies, the investigators found that a brief cognitive-behavioral therapy group decreased depressive symptoms and prevented worsening of... Read More
Gender:
FEMALE
Ages:
Between 12 years and 17 years
Trial Updated:
06/06/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Type2 Diabetes, Type 2 Diabetes Mellitus, Insulin Sensitivity, Insulin Resistance, Depression, Adolescent Obesity
Register for Updates
Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II
NCT05555875
Recruiting
This study is a clinical trial that evaluates what drives patient engagement and tests the impact of two strategies-automated motivational push messaging and coach support-to improve engagement with an evidence-based mobile app intervention for depression and/or anxiety.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
06/05/2024
Locations: Jessica Morrow Lipschitz, Boston, Massachusetts
Conditions: Depression, Anxiety Disorders
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Randomized Controlled Trial of a Behavioral Training App
NCT06447909
Recruiting
The investigators propose addressing and evaluating the efficacy of a behavioral, contingency management app by conducting a randomized controlled trial (RCT) that will evaluate the app compared to a placebo app control group. Participants will be randomly assigned to immediate intervention using the treatment condition or to a placebo app condition. Participants will not know which condition they are assigned to until after the study completion; they will also not know that they are using the t... Read More
Gender:
All
Ages:
Between 6 years and 12 years
Trial Updated:
06/03/2024
Locations: New York University, New York, New York
Conditions: Behavior, Child, Disruptive Behavior, Executive Dysfunction, Attention-deficit, Anxiety, Depression, Stress
Register for Updates
Dallas 2K: A Natural History Study of Depression
NCT02919280
Recruiting
The Dallas 2K is a 10-year natural history, longitudinal, prospective study of a cohort of 2,000 participants that will help uncover the socio-demographic, lifestyle, clinical, psychological and neurobiological factors that contribute to anti-depressant treatment response: remission, recurrence, relapse and individual outcomes in depressive disorders. Hence, the expected duration of this study is 20 years in length. Since this is an observational study, investigators will explore a comprehensive... Read More
Gender:
ALL
Ages:
10 years and above
Trial Updated:
05/24/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Depression, Depression, Bipolar
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Evaluation of the H.O.O.V.E.S. Healing Intensives Program
NCT06300255
Recruiting
The aim of this study is to measure the impact of these H.O.O.V.E.S. healing intensives on Veteran participants using several psychological instruments. The investigators are planning to administer the demographic questionnaires and psychological instruments to Veteran participants before the healing intensives. Psychological instruments will be administered immediately pre-intervention, pre- and post-session for each session, post-intervention, 90, 120 and 360 days post-intervention. The primar... Read More
Gender:
All
Ages:
Between 18 years and 120 years
Trial Updated:
05/24/2024
Locations: George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah
Conditions: Anxiety, PTSD, Depression
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The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
NCT05453513
Recruiting
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightly integrative study to test the overall hypothesis that cannabis use and depression in young PLWH have an additive effect, inducing both reward deficits and pain hypersensitivity, and that this patter... Read More
Gender:
All
Ages:
Between 18 years and 39 years
Trial Updated:
05/23/2024
Locations: University of Miami, Miami, Florida
Conditions: Hiv, Depression, Cannabis Use Disorder
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A Digital Intervention for Post-Stroke Depression and Executive Dysfunction
NCT05507138
Recruiting
Individuals with stroke commonly experience both depression and cognitive difficulties. The goal of this study is to evaluate the efficacy of a treatment that combines a digital therapeutic (an iPad-based cognitive training program) with learning cognitive strategies. The hypotheses are that this treatment will improve cognitive skills, depression symptoms, daily function, and brain connectivity. In the short-term, the findings will inform the efficacy of the intervention and in the long-term, m... Read More
Gender:
All
Ages:
Between 50 years and 79 years
Trial Updated:
05/21/2024
Locations: Weill Cornell Medical Center, New York, New York
Conditions: Executive Dysfunction, Depression, Stroke
Register for Updates