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Depression Clinical Trials
A listing of 268 Depression clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
61 - 72 of 268
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There are currently 268 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
Featured Trial
Studying an Investigational Drug as Additional Therapy Treatment for Depression
Recruiting
This phase 2/3 study aims to assess the safety and effectiveness of an investigational drug (SEP-363856) as an additional treatment for adults with Major Depressive Disorder and who have not had success with antidepressants in treating their depression symptoms. This study may be suitable for you if you have been diagnosed with depression and your previous antidepressant treatments have not been effective. Should you express interest, the research site will contact you directly to provide further details and address any questions you may have about study requirements, risks/benefits, and compensation.
Conditions:
Depression
Depressive disorder
All Conditions
Featured Trial
Narcolepsy Clinical Study
Recruiting
The Vibrance Studies are researching the safety and effectiveness of a once-daily oral investigational study drug and how it may work in adults 18–70 years of age for the potential treatment of excessive daytime sleepiness (EDS) symptoms in adults with narcolepsy type 1 (NT1) or narcolepsy type 2 (NT2).
All participants who qualify will receive the study drug or placebo (a tablet that looks like the study drug but contains no active medicine), as well as study-related procedures and study-related laboratory tests at no cost. Compensation for time and travel may also be available.
All participants who qualify will receive the study drug or placebo (a tablet that looks like the study drug but contains no active medicine), as well as study-related procedures and study-related laboratory tests at no cost. Compensation for time and travel may also be available.
Conditions:
Narcolepsy
Narcolepsy With Cataplexy
Narcolepsy Without Cataplexy
Narcolepsy 1
Narcolepsy Type 1
Featured Trial
High Triglyceride Clinical Research Study
Recruiting
Living with high triglycerides? See if our clinical study is right for you.
Don’t let financial stress hold you back. All clinical study-related assessments, care, and the investigational study drug are available at no cost. You could also be eligible for compensation for travel.
Don’t let financial stress hold you back. All clinical study-related assessments, care, and the investigational study drug are available at no cost. You could also be eligible for compensation for travel.
Conditions:
High Triglycerides
High Triglyceride Level
Hypertriglyceridemia
Elevated Triglycerides
Triglycerides High
Featured Trial
Studying an Investigational Medication's Impact on Cardiovascular Events
Recruiting
The main objectives of this Phase 3 study are to evaluate the safety and effectiveness of an investigational medication's ability to reduce major adverse cardiovascular events (such as heart attacks and strokes) in adults at risk. Participants will be randomly assigned to receive either the investigational medication or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.
Conditions:
All Conditions
Hyperlipidemia
Cardiovascular Disease
Ischemic heart disease (IHD)
Stroke
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
Recruiting
Background:
Researchers developed \[11C\]MC1, a radioligand for cyclooxygenase-2 (COX-2). COX-2 is an enzyme induced in the brain during inflammation. Researchers want to see the levels of COX-1 (measured as distribution volume VT) are elevated in the brain of two groups of mood disorders patients undergoing MDE relative to the control group.
Objective:
To determine whether COX-1 and COX-2 are detectable in the brains of individuals with MDD experiencing a major depressive episode (MDE).
Eli... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/06/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
Filipino Family Health Initiative 1.0
Recruiting
The goal of this clinical trial is to test the effectiveness of an online parenting program on Filipino parents living in California. The main aims are to:
* Test the effectiveness of the online Incredible Years® model of parent training and its impact on primary outcomes.
* Determine the impact of intervention engagement (i.e., higher attendance) on parenting practices and child behavior outcomes.
* Describe Intervention delivery and its online implementation in real-world community settings.... Read More
Gender:
ALL
Ages:
8 years and above
Trial Updated:
02/05/2025
Locations: Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California
CAPABLE Transplant
Recruiting
The purpose of this mixed methods study is to adapt CAPABLE as CAPABLE Transplant to accomplish two things: 1) To resolve barriers to being classified as active on the Kidney Transplant (KT) waitlist and 2) as a surgical prehabilitation intervention targeting the pre-frail/ frail KT waitlist population. It consists of two phases- an open label pilot and a randomized waitlist control trial.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/05/2025
Locations: Johns Hopkins School of Nursing, Baltimore, Maryland
ICBT (Internet Based Cognitive Behavioral Therapy) for Maternal Depression: Community Implementation in Head Start
Recruiting
Low income women of childbearing age are at increased risk for depression and often do not receive needed treatment. Investigators developed Mom-Net, an on-line cognitive behavioral treatment (CBT) for depression to address the needs of low income women of childbearing age. The intervention program also includes live coaching to help the mothers engage and learn the CBT material. Mom-Net has been shown to be highly effective in reducing depressive symptoms and improving parenting behavior and ch... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
02/04/2025
Locations: Oregon Research Institute, Springfield, Oregon
Conditions: Depression
Implementation of Problem-Solving Treatment in Community Health Centers (PST-Aid)
Recruiting
Although evidence-based clinical interventions (CI) are a preferred treatment option for patients with depression, CIs are rarely available in community primary care settings. When available, CIs are often delivered with poor fidelity and abandoned by practitioners during the initial months post-training. Identifying effective implementation strategies to support the adoption, reach, and sustained use with fidelity of these CIs could enhance the effectiveness of primary care-based treatment of d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: OCHIN, Inc., Portland, Oregon
Conditions: Depression
Apimostinel + Automated Neurocognitive Training for Depression
Recruiting
Apimostinel shows initial promise as a novel rapid-acting antidepressant medication with minimal side effects or safety concerns. Cognitive Training (CT) is a digital intervention that has shown promise in extending the durability of another similar drug (ketamine). This randomized controlled trial will test the efficacy and safety of apimostinel (vs. placebo) for the acute treatment of depression, and will test the potential of CT to enhance and/or extend the durability of apimostinel's antidep... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/03/2025
Locations: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Conditions: Depression
Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
Recruiting
The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/02/2025
Locations: University of Miami Neuroimaging Facility, Coral Gables, Florida +1 locations
Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Recruiting
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/02/2025
Locations: Eskenazi Hospital, Indianapolis, Indiana +1 locations
Conditions: Depression, Cognitive Decline
Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Disorders
Recruiting
US residents who have mental health issues sign the informed consent form and are screened and enrolled for this study. Participants complete a survey upon enrollment and are randomized into one of two study arms. This study is direct to participant and will NOT utilize clinical sites.
Gender:
ALL
Ages:
Between 25 years and 75 years
Trial Updated:
01/27/2025
Locations: Viome Life Sciences, Bothell, Washington
Factorial Optimization Trial to Test Effects of Coping Intervention Components
Recruiting
This study will identify components for inclusion in a coping intervention package to reduce mental health problems among children exposed to high interparental conflict after parental separation/divorce. Reappraisal, distraction, and relaxation coping strategies are related to fewer mental health problems among children, making intervention components based on these strategies key candidates for inclusion in an optimized coping intervention. The primary aim is to experimentally assess the main... Read More
Gender:
ALL
Ages:
Between 9 years and 12 years
Trial Updated:
01/27/2025
Locations: Arizona State University, Tempe, Arizona
Exercise Plus Duloxetine for Knee Osteoarthritis
Recruiting
This study evaluates the addition of duloxetine to aerobic exercise in the treatment of symptomatic knee osteoarthritis and depressive symptoms in adults. All participants will receive the receive the treatment protocol, which will first be evaluated in terms of feasibility and then pilot tested.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
01/23/2025
Locations: University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Knee Osteoarthritis, Depression
Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
Recruiting
The goal of this research study is to adapt an ACT-self-help workbook to the prison setting and determine the feasibility acceptability, and effectiveness of this workbook.
Participants can expect to be in the study for 13 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: University of Wisconsin, Madison, Wisconsin
61 - 72 of 268