There are currently 252 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
NCT06812247
Recruiting
Animal assisted therapy (AAT) with dogs has been shown to be beneficial for a wide range of patients with both acute and chronic illnesses, including spinal cord injuries, heart failure, myocardial infarctions, strokes, cancer, post-traumatic stress disorder, and depression. Studies have also demonstrated that even in healthy adults, the presence of dogs is associated with physiologic changes such as increased pain threshold, decreased blood pressure, and decreased heart rate. However, few studi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/05/2025
Locations: Boston Medical Center, Trauma Inpatient Service, Boston, Massachusetts
Conditions: Trauma Injury, Depression, Anxiety, Anger, Pain
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Probiotic Administration for Adolescent Depression
NCT06898788
Recruiting
This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age.
Gender:
ALL
Ages:
Between 15 years and 24 years
Trial Updated:
06/04/2025
Locations: UCSF, San Francisco, California
Conditions: Depression
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Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
NCT04276259
Recruiting
The central goal of this application is to demonstrate the causal contribution of reward learning signals (expected values and reward prediction errors \[RPE\]) to antidepressant responses (Aim1) by experimentally manipulating expected values using transcranial magnetic stimulation (TMS) targeting the vmPFC (Aim 2) and μ-opioid striatal RPE signal using pharmacological approaches (Aim 3).
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/03/2025
Locations: Bellefield Tower, Pittsburgh, Pennsylvania
Conditions: Major Depressive Disorder, Depression
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Cognitive and Affective Processes Online
NCT05736471
Recruiting
This study will provide data for evaluating the psychometric characteristics of the tests assessing cognitive flexibility, including their (1) internal consistency, (2) feasibility and tolerability, their (3) convergent and discriminant validity of cognitive and affective constructs such as those introduced to understand mental disorders, and (4) sensitivity (and correspondence) to individual differences. For these tests to be useful in studying clinical conditions, they must show adequate relia... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Depression
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Treating Psychosocial Distress in Glaucoma
NCT06053307
Recruiting
In this study, using three phases, the investigators will use an iterative development approach to refine a behavioral intervention for managing concomitant psychosocial distress in glaucoma. Phase 1: The investigators will begin by developing a baseline intervention using strategies from Acceptance and Commitment Therapy (ACT), and delivered using a mobile application. Phase 2: The investigators will refine the baseline intervention for glaucoma patients using qualitative interviews conducted w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Glaucoma, Primary Open Angle, Distress, Emotional, Anxiety, Depression
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Assessing Improvements in Mood and Sleep Trial
NCT06639477
Recruiting
This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt). Our goal is evaluate which of two different approaches works best to improve things like trouble sleeping, bad moods, and any suicidality. Participants will complete diagnostic interviews, self-report scales, and wear an actigraphy device for the 8 weeks starting at the baseline visi... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
06/02/2025
Locations: The Regents of the University of California, Los Angeles, Los Angeles, California +2 locations
Conditions: Depression, Suicidality, Sleep
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Digital CBT for Insomnia and Depression
NCT05456607
Recruiting
This study has two primary objectives, each of which addresses critical clinical and research gaps for individuals who have co-occurring insomnia and depression. The first objective is to address whether sequential treatment of insomnia and depression is superior to a single treatment for either depression or for insomnia, and if so, which treatment sequence is optimal. The second objective is to determine if there are heterogeneity of treatment effects; that is, variation in which interventions... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: University of Rochester Sleep Research Laboratory, Rochester, New York
Conditions: Depression, Insomnia
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Mental Health App for Cancer Survivors Study
NCT06472726
Recruiting
The goal of this clinical trial is to adapt a mental health digital app to treat depression among head and neck cancer patients and survivors. Participants will download and use the digital mental health app for a 6-week period, and will complete related surveys.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
05/29/2025
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Head and Neck Cancer, Head and Neck Cancers, Depression
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Storytelling and Mindfulness for Graduate Student Wellbeing
NCT05826860
Recruiting
The purpose of this study is to evaluate an intervention for improving Science, Technology, Engineering, and Math (STEM) graduate student wellbeing. Participants will be recruited from the University of Wisconsin-Madison graduate student body. Data will be collected from participants for up to 2 years, and the investigators anticipate that the study will last for 4 years.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/29/2025
Locations: Wisconsin Institute for Discovery, Madison, Wisconsin
Conditions: Depression, Anxiety, Burnout, Student
Register for Updates
Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions
NCT06557005
Recruiting
The lack of postpartum primary care coordination is a missed opportunity to increase primary care engagement and manage chronic conditions early in life, especially for the \>30% of pregnant people who have or are at risk for these conditions. This study aims to increase postpartum primary care engagement, quality, and experience by strengthening postpartum transitions to primary care using a behavioral economics-informed, multi-component intervention integrated into usual inpatient postpartum c... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypertension, Diabetes, Postpartum, Pregnancy, Anxiety, Depression, Obesity
Register for Updates
A Digital Intervention for Post-Stroke Depression and Executive Dysfunction
NCT05507138
Recruiting
Individuals with stroke commonly experience both depression and cognitive difficulties. The goal of this study is to evaluate the efficacy of a treatment that combines a digital therapeutic (an iPad-based cognitive training program) with learning cognitive strategies. The hypotheses are that this treatment will improve cognitive skills, depression symptoms, daily function, and brain connectivity. In the short-term, the findings will inform the efficacy of the intervention and in the long-term, m... Read More
Gender:
ALL
Ages:
Between 50 years and 79 years
Trial Updated:
05/23/2025
Locations: Weill Cornell Medical Center, New York, New York
Conditions: Executive Dysfunction, Depression, Stroke
Register for Updates
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
NCT06433635
Recruiting
This is a sequential multiple assignment randomized trial for adults (ages \> 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic trial that will compare four commonly prescribed treatments for bipolar depression, which includes three FDA-approved medications (Cariprazine, Quetiapine and Lurasidone) and one antipsychotic/antidepressant combination (Aripiprazole/Escitalopram).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/21/2025
Locations: University of Alabama Birmingham, Birmingham, Alabama +16 locations
Conditions: Bipolar I Disorder, Depression
Register for Updates