There are currently 256 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Sleep Mechanisms Of Regulating Emotions
Recruiting
This project is the second phase of a two-phased project investigating the impact of a proven sleep intervention, Cognitive Behavioral Therapy for Insomnia (CBT-I) on engagement of the emotion regulation brain network as a putative mechanistic target.
Gender:
ALL
Ages:
Between 25 years and 60 years
Trial Updated:
05/07/2025
Locations: Stanford University, Palo Alto, California
Conditions: Insomnia, Depression
Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities
Recruiting
This study is a randomized Type I hybrid effectiveness-implementation trial aimed at evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program supported by social service providers, in comparison to enhanced usual care for depression in older adults with ambulatory disabilities. A total of 64 participants with ambulatory disabilities will be randomly assigned to either the treatment group (Empower@Home) or the control group (enhanced usual car... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/07/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Depression
Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD
Recruiting
This project aims to adapt, implement, and evaluate a Dialectical Behavior Therapy skills training group intervention for aging adult family caregivers of person with Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) to reduce suicidality. By adapting this modality, the investigators will provide a scalable intervention tailored for this high-risk population, maximizing the public health impact and improving suicide prevention.
Gender:
ALL
Ages:
Between 50 years and 120 years
Trial Updated:
05/06/2025
Locations: Garrison Institute on Aging, Lubbock, Texas
Conditions: Suicide, Depression, Caregiver Burden, Physical Health, Inflammation
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
Recruiting
It is envisioned that multipronged benefits from this pilot work for the UPMC ISD and its members. It is expected the RxWell platform to provide the following benefits: expansion of the use of RxWell to all UPMC ISD members providing peri-operative mood management with advantage of improved peri-operative outcomes, improving saving for the UPMC ISD by hastening the recovery and decreased resource utilization, and addition to the high-value care of UPMC with this holistic approach to patient peri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: UPMC East, Monroeville, Pennsylvania +2 locations
Conditions: Mood Disorders, Anxiety, Depressive Symptoms, Depression, Anxiety Disorders, Anxiety Depression
Expanding First-line Options for Depression and Matching Treatments to Patients: Hatha Yoga vs. Behavioral Therapy
Recruiting
This is a parallel group study design. The investigators propose to compare an online, synchronous group-based yoga intervention developed for individuals with depression to an online, synchronous individualized, evidence-based behavioral therapy for depression, or Brief Behavioral Activation Treatment for Depression (BA). This study is a multi-site randomized trial of adults with clinically significant depressive symptoms. Participants (N=518) will be randomized in an equal allocation ratio (i.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Giuliana Chau, Boston, Massachusetts
Conditions: Depression
Resilience in Adolescent Development
Recruiting
RAD is a 10-year natural history, longitudinal, prospective assessment study of a cohort of 2,500 participants (ages 10-24 years) that will help uncover the socio-demographic, lifestyle, clinical, psychological, and neurobiological factors that contribute to resilience among children, adolescents, and young adults at-risk for mood and anxiety disorders. As this is an exploratory study, we will assess a comprehensive panel of carefully selected participant specific parameters, including socio-dem... Read More
Gender:
ALL
Ages:
Between 10 years and 24 years
Trial Updated:
05/04/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Risk Assessment, Resilience, Psychological, Depression, Mood Disorders, Anxiety Disorders, Mental Health
Acceptance and Commitment Therapy for Depressed People With Spinal Cord Injuries
Recruiting
Living with spinal cord injury (SCI) can have a significant negative impact on an individual's mental health and restrict participation in personally valued activities and roles. Acceptance and commitment therapy (ACT) is an evidence-based approach that can lessen symptoms of mental health disorders (e.g., depressive symptoms) and improve quality of life through mindfulness and acceptance processes and behavior change processes for valued living. Evidence for ACT for individuals living with SCI,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Depression, Spinal Cord Injuries
Dallas 2K: A Natural History Study of Depression
Recruiting
The primary objective of this initiative is to implement a prospective study that will allow us to identify and validate biosignatures of response to treatments for depression and depression outcome (using an integrated array of participant specific data: socio-demographic, lifestyle, clinical and behavioral assessments, fluid-based biomarkers, genomics, neuroimaging, EEG, and cell-based assays) in a longitudinal cohort of subjects with elevated symptoms of a depressive disorder. Symptom remiss... Read More
Gender:
ALL
Ages:
10 years and above
Trial Updated:
05/02/2025
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Depression, Depression, Bipolar
Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)
Recruiting
This study is a randomized Type I hybrid effectiveness-implementation trial aimed at evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program supported by aging service providers, in comparison to enhanced usual care for homebound older adults with depressive symptoms. A total of 256 participants will be randomly assigned to either the treatment group (Empower@Home) or the control group (enhanced usual care) in a 1:1 allocation ratio, with ra... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/02/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Depression
Teen Brain Online II: Understanding How Social Media Affects the Teen Brain
Recruiting
There has been much interest in the potential role of social media (SM) use in driving a current mental health crisis among teens, with a dire need for evidence that goes beyond self-report. One important avenue is to understand the role of the brain in driving the effects of SM use on emotional health and vice versa. However, there is almost no research addressing these questions, largely due to a lack of tasks that can probe the neural correlates of modern SM use. The goal of this clinical tri... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
05/01/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Depression
Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans
Recruiting
The goal of this phase 1 study is to investigate the safety and efficacy of dimethyltryptamine (DMT) in individuals with depression and healthy controls. We hypothesize that administration of DMT will result in decreases in depression, associated symptoms, and neuroplastic changes in depressed subjects. We expect that DMT will induce changes in neuroplasticity as indexed using electroencephalographic (EEG) measures and tasks in both depressed individuals and healthy volunteers, though to differe... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
05/01/2025
Locations: Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine,, West Haven, Connecticut
Conditions: Major Depression Disorder, Depression
Project neuroARTEMIS
Recruiting
The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. This study is intended for individuals that are HIV positive, currently taking prescription antiretroviral medications, and use stimulants. Through this... Read More
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
04/30/2025
Locations: Wake Forest University School of Medicine, Winston-Salem, North Carolina
Conditions: Stimulant Use, Human Immunodeficiency Virus (HIV), Depression