There are currently 253 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Long-term Observation of Participants With Mood Disorders
NCT04877977
Recruiting
Background: More than 12,000 people have taken part in research at the Experimental Therapeutics \& Pathophysiology Branch at the National Institute of Mental Health Intramural Program. This has led to advances in the treatment of depression, bipolar disorder, and suicide risk. Researchers want to follow up with this group to see if they continue to have mental health symptoms and receive psychiatric treatments. Objective: To learn the long-term impact of depression, bipolar disorder, and sui... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/03/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression, Suicide Risk
Register for Updates
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
NCT04582916
Recruiting
Background: Researchers developed \[11C\]MC1, a radioligand for cyclooxygenase-2 (COX-2). COX-2 is an enzyme induced in the brain during inflammation. Researchers want to see the levels of COX-1 (measured as distribution volume VT) are elevated in the brain of two groups of mood disorders patients undergoing MDE relative to the control group. Objective: To determine whether COX-1 and COX-2 are detectable in the brains of individuals with MDD experiencing a major depressive episode (MDE). Eli... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/03/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
Register for Updates
Functional Connectivity Alterations in Suicidal Patients Among Opioid Users
NCT05489042
Recruiting
Suicide is the 10th leading cause of death for Americans of all ages and more people in the United States now die from suicide than die from car accidents. Although death by firearm remains the most common cause of suicide in the United States, an intentional overdose of substance usage such as prescription opioids accounts for over 5,000 suicides per year. In 2017, more than 70,000 drug overdose deaths occurred, making it the leading cause of injury-related death, and well over half (67.8%) inv... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/02/2025
Locations: The Menninger Clinic, Houston, Texas
Conditions: Substance Abuse, Suicide, Depression
Register for Updates
Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)
NCT05942469
Recruiting
FOREST is a positive emotion skills program designed to target mental health and coping needs for frontline violence prevention workers at UCAN. Ten skills are taught over a period of nine months during existing meetings and wellness activities, as well as in online modules in UCAN's Learning Management System (LMS). Through infusing the FOREST skills throughout UCAN, we hope to inspire organizational culture change that will emphasize the importance of wellbeing and enhance resilience, therefor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Northwestern University Feinberg School of Medicine, Chicago, Illinois
Conditions: Burnout, Burnout, Professional, Positive Affect, Depression, Anxiety, Compassion Fatigue, Job Stress
Register for Updates
Developing and Testing an Online Pathway From Screening to Treatment for Depression in Oncology: iPath*D (Aim 2)
NCT05302375
Recruiting
The purpose of this study is to determine the extent to which an online pathway to depression treatment (iPath\*D) is acceptable and usable to patients receiving cancer treatment who report symptoms of depression.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Dartmouth Cancer Center St. Johnsbury, Saint Johnsbury, Vermont
Conditions: Cancer, Depression
Register for Updates
Retrospective Analyses of TrakStar Database
NCT06917339
Recruiting
In this study, real-world data will be used to better understand the effects patient characteristics, symptoms and TMS protocol parameters have on clinical outcomes with NeuroStar TMS.
Gender:
ALL
Ages:
Between 5 years and 120 years
Trial Updated:
03/31/2025
Locations: Neuronetics, Malvern, Pennsylvania
Conditions: Depression, Obsessive-Compulsive Disorder, Anxiety Depression
Register for Updates
Mental Health App for Cancer Survivors Study
NCT06472726
Recruiting
The goal of this clinical trial is to adapt a mental health digital app to treat depression among head and neck cancer patients and survivors. Participants will download and use the digital mental health app for a 6-week period, and will complete related surveys.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/28/2025
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Head and Neck Cancer, Head and Neck Cancers, Depression
Register for Updates
Chronobiological Basis of Menopausal Depression: Correcting Misaligned Circadian Rhythms With Sleep and Light Interventions
NCT06678880
Recruiting
The goal of this clinical trial is to learn more about mood, sleep, and activity during menopause. The main question it aims to answer is: can mood and sleep dysfunction in menopause be improved by resetting misaligned circadian rhythm through one night of strategic sleep timing adjustment and two weeks of exposure to bright light at a certain time of day? Researchers will compare sleep timing (earlier vs. later) and bright white light exposure (morning or evening) to investigate the effect of m... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of California San Diego Hillcrest Medical Center, San Diego, California
Conditions: Depression, Depression During the Menopausal Transition, Menopausal Depression
Register for Updates
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
NCT06627894
Recruiting
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/27/2025
Locations: Eskenazi Hospital, Indianapolis, Indiana +1 locations
Conditions: Depression, Cognitive Decline
Register for Updates
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
NCT05703685
Recruiting
Background: Major depressive disorder (MDD) is a psychiatric condition. People with MDD have occasional bouts of depressive symptoms; these bouts are called major depressive episodes (MDEs). Researchers want to know if people having MDEs have lower levels of an enzyme called PDE4B in their brains. Primary Objective: To determine whether PDE4B is reduced in the brains of individuals with MDD experiencing a major depressive episode (MDE). Secondary Objectives: To determine the optimal length of... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/26/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
Register for Updates
Collaborative Care for Anxiety and Depression in Epilepsy
NCT05559749
Recruiting
This is a randomized effectiveness/implementation trial comparing a 24-week neurology-based collaborative care intervention to usual neurology care among 60 adults with epilepsy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Epilepsy, Anxiety, Depression
Register for Updates
Brief, High-dose rTMS for Depression
NCT04657432
Recruiting
High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination. The purpose of this study is to systematically examine an accelerated protocol of intermittent theta burst (iTBS). Study 1 aims to provide a quantifiable dose-response curve for iTBS and depressive symptom reduction in major depression. Study 2 aims to determine the role of indi... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/25/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Depression, Anxiety
Register for Updates