There are currently 281 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
NCT05663034
Recruiting
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based treatment for insomnia (MBTI) in treating insomnia symptoms and ameliorating depressive symptoms in persons with mild to moderate TBI and comorbid Post-Traumatic Stress Symptoms (PTSS) and insomnia symptoms in a 360 patients. Participants will undergo as... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/14/2024
Locations: Intrepid Spirit Center - Eglin Air Force Base, Eglin Air Force Base, Florida +3 locations
Conditions: Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress, Sleep, Memory Impairment, Cognitive Behavioral Therapy, Concussion, Brain, Head Injury, Brain Injury Traumatic Mild
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Pramipexole to Enhance Social Connections
NCT06269146
Recruiting
This study seeks to understand if the medication pramipexole improves social connectedness and functioning in adults (ages 18-50) who experience anxiety or depression. The study plans to enroll 108 participants total across two sites (University of California San Diego and New York State Psychiatric Institute). Pramipexole will be given in a 6-week randomized, double-blind, placebo-controlled trial. Social reward processing will be assessed using measures of brain function (fMRI), behavior, and... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
05/13/2024
Locations: University of California, San Diego, San Diego, California +1 locations
Conditions: Anxiety Disorders, Anxiety, Depression, Social Disconnection
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Behavioral Activation-Rehabilitation to Improve Depressive Symptoms & Physical Function After Acute Respiratory Failure
NCT03431493
Recruiting
More and more people are surviving after receiving life support for respiratory failure in the intensive care unit, but these patients often experience problems with depression and physical functioning that lead to reduced quality of life. There is a lack of treatment for these patients, with past research suggesting that treatment may be more successful if mental and physical health are addressed at the same time. This research evaluates whether a therapy delivered via telephone and home visits... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
05/10/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Respiratory Insufficiency, Depression, Rehabilitation, Critical Care
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Transcranial Magnetic Stimulation for MCI
NCT05992831
Recruiting
The goal of this phase II study is to establish the dose-response curves of a safe and clinically feasible non-invasive brain stimulation technique (accelerated Transcranial Magnetic Stimulation (TMS)) to improve both depression and cognitive function in Mild Cognitive Impairment (MCI) patients with comorbid depression. It is known that TMS can effectively treat depression. Identifying the right dose of accelerated TMS in MCI patients is necessary prior to designing subsequent trials to determin... Read More
Gender:
All
Ages:
Between 60 years and 85 years
Trial Updated:
05/10/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Mild Cognitive Impairment, Depression
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Internet Based Psychological Support
NCT02726061
Recruiting
The investigators have developed interactive, multimedia-intensive, computer-based treatment programs that include depression (Problem-Solving Therapy), stress management, and conflict management. Together the three modules are called PATH. The problem-solving module is based on an evidence-based psychotherapy called Problem-Solving Therapy in which depressed patients identify problems in their lives and work through a structured format for solving these problems. We have subjected the problem-... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/10/2024
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Depression, Stress, Conflict Resolution
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Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression
NCT05772702
Recruiting
The purpose of this research study is to study closed-loop transcranial alternating current stimulation (tACS) to determine its effects on symptoms of depression in people with major depressive disorder.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
05/09/2024
Locations: Carolina Center for Neurostimulation, Chapel Hill, North Carolina
Conditions: Depression, Major Depressive Disorder, tACS
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Virtual Reality-Reward Training for Anhedonia
NCT05342077
Recruiting
The purpose of this study is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. VR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. Target enrollment is 80 male and female part... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Positive Affect, Depression
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Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
NCT05094297
Recruiting
This research study is being done to investigate if the GH Method exercise program positively affects body composition, improves physical abilities and can improve the overall sense of wellbeing (e.g. depression, PTSD, etc.) in U.S. Veterans. Subjects will be asked to complete 94 total visits (four (4) study testing visits and 90 exercise visits). Enrolled subjects will be tested for fitness, strength, and health risk factors at UIC 4 times and will complete 90 exercise training visits at the GH... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Chronic Pain, Acute Pain, Fatigue, Depression
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PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
NCT04582916
Recruiting
Background: Researchers developed [11C]MC1, a radioligand for cyclooxygenase-2 (COX-2). COX-2 is an enzyme induced in the brain during inflammation. Researchers want to see the levels of COX-1 (measured as distribution volume VT) are elevated in the brain of two groups of mood disorders patients undergoing MDE relative to the control group. Objective: To determine whether COX-1 and COX-2 are detectable in the brains of individuals with MDD experiencing a major depressive episode (MDE). Eligi... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
05/07/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
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Dose-Response Effect Exercise and Depression
NCT06166095
Recruiting
The present study aims to address gaps in the literature by evaluating the objectively measured dose-response relationship between exercise and depression symptoms; examining changes in resting (Brain-derived Neurotrophic Factor) BDNF from baseline to week 10 of an exercise intervention; and assessing varying exercise intensities on enjoyment, affect, and health-related quality of life in sedentary young adult college students.
Gender:
All
Ages:
Between 18 years and 25 years
Trial Updated:
05/06/2024
Locations: University of Central Florida, Orlando, Florida
Conditions: Depression
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Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
NCT05925322
Recruiting
The investigators hypothesized that during the 9-week course of Engage & Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
05/06/2024
Locations: Weill Cornell Medicine, New York, New York
Conditions: Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
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Cannabidiol and Older Adult Cannabis Users
NCT06290063
Recruiting
Cannabis use increased 10 fold among adults over the age of 65 between 2014 and 2016 but very little data exists on the extent of their harmful effects on health and behavior. The overarching goal of this project is to test a novel harm reduction strategy in which older individuals who seek to use cannabis for pain, anxiety or mood problems (depression/anxiety) will be randomly assigned to one of three conditions in an 8 week randomized controlled trial: hemp-derived CBD+THC, hemp-derived CBD-TH... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
05/06/2024
Locations: University of Colorado at Boulder, Boulder, Colorado
Conditions: Sleep, Anxiety, Depression, Pain
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