There are currently 252 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
NCT06433635
Recruiting
This is a sequential multiple assignment randomized trial for adults (ages \> 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic trial that will compare four commonly prescribed treatments for bipolar depression, which includes three FDA-approved medications (Cariprazine, Quetiapine and Lurasidone) and one antipsychotic/antidepressant combination (Aripiprazole/Escitalopram).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/21/2025
Locations: University of Alabama Birmingham, Birmingham, Alabama +16 locations
Conditions: Bipolar I Disorder, Depression
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Inflammation and Depression in People With HIV
NCT05849038
Recruiting
The purpose of this 10-week, double-blind, placebo-controlled study is to determine whether inflammation impacts reward and motor neural circuitry to contribute to depressive symptoms like anhedonia and psychomotor slowing in people with Human Immunodeficiency Virus (HIV) and depression. Sixty male and female patients with HIV who have depression, anhedonia and high inflammation and are stable on effective treatment for their HIV will be randomized to receive either the anti-inflammatory drug ba... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/21/2025
Locations: Grady Memorial Hospital, Atlanta, Georgia +1 locations
Conditions: HIV, Depression, Anhedonia
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A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
NCT05081596
Recruiting
The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
05/20/2025
Locations: Weill Cornell Medicine, White Plains, New York
Conditions: Depression, Pain, Cognitive Impairment
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Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
NCT05474846
Recruiting
To learn if Cognitive Behavior Therapy (called CBT), combined with either Bright Light Therapy (called BLT), methylphenidate, and/or melatonin, can help improve sleep and other related symptoms such as fatigue, anxiety, and depression in cancer patients. This is an investigational study. In this study, BLT, Methylphenidate and Melatonin will be compared to their placebos.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Sleep, Fatigue, Anxiety, Cancer, Depression
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Investigation to Understand and Optimize Psilocybin
NCT06512194
Recruiting
This study will examine the effects of a single dose of psilocybin, administered with psychological support, on symptoms of depression. It will also assess whether different post-dosing interventions, including a non-invasive technique called transcutaneous auricular Vagus Nerve Stimulation (taVNS), influence various psychological and behavioral outcomes. In addition, the study will explore objective measures of real-world social behavior and identify early behavioral responses that may be assoc... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/19/2025
Locations: Vail Health Behavioral Health, Edwards, Colorado
Conditions: Depression
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SilverCloud as a School-Based Intervention for Vulnerable Youth
NCT06004414
Recruiting
The goal of this study is to test the efficacy and feasibility of a clinician-guided, app-based cognitive behavioral therapy (CBT) program, SilverCloud, as a school-based mental health intervention for vulnerable youth. An open trial of SilverCloud will be conducted to determine preliminary efficacy in this sample and inform program refinements by collecting outcome self-report assessments and conducting interviews on feasibility and acceptability. After the program and its implementation strate... Read More
Gender:
ALL
Ages:
Between 13 years and 22 years
Trial Updated:
05/16/2025
Locations: Rutgers University, New Brunswick, New Jersey +2 locations
Conditions: Depression, Anxiety
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PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
NCT06713616
Recruiting
The purpose of this study is to compare the relative effectiveness, acceptability, and side effects of ketamine delivered through an IV (a drip into the arm) which is not currently FDA approved for use in the treatment of treatment-resistant depression (TRD) and Esketamine (Spravato®), taken as a nasal spray which has received FDA approval for use in the treatment of treatment-resistant depression (TRD) in the treatment of patients with treatment-resistant depression (TRD). The study will look a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: Mood Institute, Milford, Connecticut +5 locations
Conditions: Depression
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CAPABLE Transplant
NCT06326905
Recruiting
The purpose of this mixed methods study is to adapt CAPABLE as CAPABLE Transplant to accomplish two things: 1) To resolve barriers to being classified as active on the Kidney Transplant (KT) waitlist, 2) as a surgical prehabilitation intervention targeting the pre-frail/ frail KT waitlist population. It consists of two phases- an open label pilot and a randomized waitlist control trial, and 3) pilot test the feasibility and acceptability for CAPABLE Transplant in symptom and waitlist specific me... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Johns Hopkins School of Nursing, Baltimore, Maryland
Conditions: Quality of Life, Depression, End Stage Renal Disease, Disability Physical
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Family Acceptance Project Online (Pilot RCT)
NCT06839859
Recruiting
Research shows that sexual and gender minority youth (SGMY) experience high rates of mental health problems and other challenges (e.g., social, academic). A major factor that leads to these challenges is family rejection (family behaviors and reactions that minimize, deny, ridicule and attempt to prevent or change a child's sexual orientation, gender identity and gender expression). Racial and ethnic minority youth experience the highest rates of family rejection and related health risks. The F... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
05/08/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: LGBTQ, Racial Disparities, Family Relationships, Minority Stress, Depression, Anxiety, Drug Use, Teen Dating Violence, Sexual Risk Reduction
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Psilocybin Therapy for Depression in Parkinson's Disease
NCT06455293
Recruiting
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
05/08/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Parkinson Disease, Depression
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Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities
NCT06721559
Recruiting
This study is a randomized Type I hybrid effectiveness-implementation trial aimed at evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program supported by social service providers, in comparison to enhanced usual care for depression in older adults with ambulatory disabilities. A total of 64 participants with ambulatory disabilities will be randomly assigned to either the treatment group (Empower@Home) or the control group (enhanced usual car... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/07/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Depression
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Sleep Mechanisms Of Regulating Emotions
NCT06373718
Recruiting
This project is the second phase of a two-phased project investigating the impact of a proven sleep intervention, Cognitive Behavioral Therapy for Insomnia (CBT-I) on engagement of the emotion regulation brain network as a putative mechanistic target.
Gender:
ALL
Ages:
Between 25 years and 60 years
Trial Updated:
05/07/2025
Locations: Stanford University, Palo Alto, California
Conditions: Insomnia, Depression
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