California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Precision Performance Status Compared With ECOG Performance Status
NCT07082257
Recruiting
This study compares consumer movement trackers to the Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) in monitoring cancer patient movement. The ECOG PS emphasizes a patient's ambulatory status (ability to walk around), and scores patients on a scale of 0-5: 0 (no restrictions), 1 (ambulatory), 2 (\< 50% of hours spent in bed, unable to carry out work activities), 3 (\> 50% of hours spent in bed, limited in self care), 4 (bedbound and gravely disabled) and 5 (deceased). Accurat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Los Angeles General Medical Center, Los Angeles, California
Conditions: Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Register for Updates
Atacicept in Multiple Glomerular Diseases
NCT06983028
Recruiting
The purpose of this study is to evaluate the safety and tolerability of atacicept in adult and adolescent participants and to measure the effect in reducing proteinuria and preserving renal function.
Gender:
ALL
Ages:
10 years and above
Trial Updated:
07/21/2025
Locations: Vera Therapeutics, Brisbane, California
Conditions: pMN, IgAN, Nephrotic Syndrome, MCD, FSGS
Register for Updates
Study of BMN 349 Single Dose in PiZZ and PiMZ/MASH Adult Participants
NCT06738017
Recruiting
The goal of this clinical trial is to assess the safety and tolerability of a single oral dose of BMN 349 in participants with PiZZ or PiMZ/MASH. Primary outcome measures include incidence of any adverse events (including serious adverse events, dose limit toxicities, and adverse events of special interest), incidence of any laboratory test abnormalities, incidence of lung function test abnormalities and 12-lead ECG parameters. Participants will receive a single dose of either BMN 349 or place... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/21/2025
Locations: University of California, San Diego, San Diego, California
Conditions: Alpha 1-Antitrypsin Deficiency
Register for Updates
A Study to Test Whether BI 1356225 Improves Impulsive Behavior in Men With Opioid Use Disorder Who Are Taking Buprenorphine
NCT06628622
Recruiting
This study is open to men between 18 and 65 years of age with opioid use disorder. Opioid use disorder is also called opioid addiction or opioid dependence. People can join the study if they currently take a medicine called buprenorphine. People with opioid dependence can act on impulse, which can lead to risky behaviours. The purpose of this study is to find out whether a medicine called BI 1356225 improves impulse control in men with opioid dependence. Participants are put into 2 groups by ch... Read More
Gender:
MALE
Ages:
Between 18 years and 65 years
Trial Updated:
07/21/2025
Locations: Collaborative Neuroscience Research, LLC, Los Alamitos, Los Alamitos, California
Conditions: Opioid Use Disorder
Register for Updates
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of INV-9956 in Adult Patients With Advanced Metastatic Castration Resistant Prostate Cancer
NCT06609005
Recruiting
This is a Phase 1 and Phase 2 study to determine the safety profile, RDR and/or MTD, DLT, PK/PD, and preliminary antitumor activity of INV-9956 in adult patients with advanced mCRPC.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Hoag Family Cancer Institute, Newport Beach, California
Conditions: Advanced Metastatic Castration Resistant Prostate Cancer
Register for Updates
Non-healing Diabetic Foot Ulcers Treated With Standard Care With or Without BR-AM
NCT06565156
Recruiting
This trial is a multicenter, randomized, controlled study designed to evaluate the safety and efficacy of BioREtain® Amniotic Membrane (BR-AM) plus standard of care versus standard of care only in the treatment of diabetic foot ulcers. The trial design will control potential variables that may affect the outcome between the treatment group and the control group by standardizing the requirements for debridement, wound dressings, and offloading. Weekly subject visits will help monitor compliance i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Site 19, Palmdale, California
Conditions: Non-infected Diabetic Foot Ulcer, Diabetic Foot, Diabetic Wound, Diabetic Foot Ulcer, Non-ischemic Diabetic Foot Ulcer
Register for Updates
A Study of ZW171 in Participants With Advanced or Metastatic Mesothelin-expressing Cancers
NCT06523803
Recruiting
This study is being done to find out if ZW171 is safe and can treat participants with advanced (locally advanced \[inoperable\] and/or metastatic) mesothelin-expressing cancers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: University of Southern California - Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Mesothelin-expressing Advanced Cancers
Register for Updates
Study of ALTO-101 in Patients With Schizophrenia
NCT06502964
Recruiting
This is a Phase 2, double-blind, placebo-controlled, two-way crossover study to compare the efficacy of ALTO-101T versus placebo in change in electroencephalogram (EEG) cognitive processing markers and measures of cognition. Additional goals are to assess pharmacokinetic (PK), safety, and tolerability of the recently developed ALTO-101T transdermal delivery system (TDS) formulation in a patient population.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
07/21/2025
Locations: Site 5038, Garden Grove, California
Conditions: Schizophrenia, Cognitive Impairment
Register for Updates
Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.
NCT06473779
Recruiting
The objective of this study is to assess the potential for tezepelumab-treated patients (subcutaneous administration) to reduce maintenance therapy without loss of asthma control in adolescent and adults with severe asthma.. Study details include: 1. The study duration will be up to 72 weeks. 2. The treatment duration will be up to 68 weeks. 3. The visit frequency will be once every 4 weeks (Q4W).
Gender:
ALL
Ages:
Between 12 years and 80 years
Trial Updated:
07/21/2025
Locations: Research Site, Palmdale, California
Conditions: Severe Asthma
Register for Updates
INHANCE Stemless Reverse Shoulder IDE
NCT06323980
Recruiting
2:1 Randomized, Controlled, Multi-Center, Prospective, Pre-Market Study of the INHANCE Stemless Reverse Cementless Total Shoulder.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
07/21/2025
Locations: Hoag Orthopedic Institute, Irvine, California
Conditions: Arthroplasty, Replacement, Shoulder
Register for Updates
Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma
NCT06252675
Recruiting
This phase II trial tests the safety and effectiveness of glofitamab given in combination with pirtobrutinib in treating patients with mantle cell lymphoma that has come back after a period of improvement (relapsed) or that has not responded to previous treatment (refractory). Glofitamab and obinutuzumab are monoclonal antibodies that may interfere with the ability of cancer cells to grow and spread. Obinutuzumab may also reduce the risk of immune-related conditions from treatment. Pirtobrutinib... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Mantle Cell Lymphoma
Register for Updates
Pulse Oximeter Accuracy in Healthy Humans During Hypoxia
NCT06142019
Recruiting
The aim of this project is to test the accuracy of pulse oximeters during mild, moderate and severe hypoxia. This is done by comparing the reading of the pulse oximeter during brief, steady state hypoxia with a gold-standard measurement of blood oxygen. This study will be done on healthy male or females between the age group of 18-50.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/21/2025
Locations: Hypoxia Lab, UCSF Department of Anesthesia and Perioperative Care, San Francisco, California
Conditions: Hypoxia, Skin Pigmentation
Register for Updates