California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MEASuRE: Metreleptin Effectiveness And Safety Registry
Recruiting
The study is a post-authorization, prospective, voluntary registry of patients treated with commercial metreleptin including, but not limited to, patients in the US and EEA.
Gender:
All
Ages:
All
Trial Updated:
11/23/2022
Locations: City of Hope, Duarte, California
Conditions: Generalised Lipodystrophy, Partial Lipodystrophy
AngioSafe Peripheral CTO Crossing System Study (RESTOR-1 Study)
Recruiting
The study is designed to evaluate the safety and efficacy of the AngioSafe Peripheral CTO Crossing System.
Gender:
All
Ages:
22 years and above
Trial Updated:
11/22/2022
Locations: Adventist Health St. Helena, Saint Helena, California
Conditions: Peripheral Artery Occlusion, Peripheral Arterial Disease
Two Year Developmental Follow-up for PREMOD2 Trial (Premature Infants Receiving Milking or Delayed Cord Clamping)
Recruiting
An extension of the PREMOD2 trial, the PREMOD2 Follow-Up trial will evaluate the neurodevelopmental outcomes at 22-26 months corrected age of preterm children who received UCM or DCC. This prospective multi-national randomized controlled trial (RCT) is a two-arm parallel non-inferiority design of two alternative approaches of treatment.
Gender:
All
Ages:
Between 22 months and 42 months
Trial Updated:
11/22/2022
Locations: Loma Linda Medical Center, Loma Linda, California
Conditions: Neurodevelopmental Abnormality
Effects of a Multispecies Probiotic on Migraine
Recruiting
The prevalence of migraine is higher in female patients with various intestinal diseases. An explanation could be that migraine is caused by a leaky gut, defined by increased intestinal permeability that permits particles to pass through the gastrointestinal wall. Probiotics, may be able to improve intestinal barrier function. OBJECTIVE: To test whether probiotics, as adjucnt therapy, can reduce incidence and severity of migraine attacks by reducing intestinal permeability.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
11/21/2022
Locations: Scripps Center for Integrative Medicine, La Jolla, California
Conditions: Migraine, Irritable Bowel Syndrome, Headache, Migraine
Exploratory Open Label Study for Development of a Method To Detect Dendritic Cells
Recruiting
This is a proof-of-concept study designed to confirm that human phagocytic cells can be labeled with the near-infrared dye indocyanine green (ICG) and the presence of the labeled cells 48 hours later in cerebral cortex can be inferred using near infrared spectroscopy (NIRS).
Gender:
All
Ages:
Between 21 years and 90 years
Trial Updated:
11/10/2022
Locations: CNS, A Division of APEX Innovative Sciences, Long Beach, California
Conditions: Probable Alzheimer's Disease
TruGraf® Long-term Clinical Outcomes Study
Recruiting
This is a prospective, multi-center, observational study. Subjects will have OmniGraf™ (TruGraf® and TRAC™) testing at study enrollment and thereafter every 3 months. In addition subjects will have OmniGraf™ (TruGraf® and TRAC™) testing at any time there is a clinical suspicion of acute rejection. Data collection for the primary objective extends over a 2-year period.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/10/2022
Locations: Fresno Nephrology Medical Group, Fresno, California
Conditions: Kidney Transplant Rejection
Non-invasive Pulmonary Artery Prediction
Recruiting
Cardiac remote monitoring devices have expanded our ability to track physiological changes used in the diagnosis and management of patients with cardiac disease. Implantable remote monitoring technologies have been shown to predict heart failure events, and guide therapy to reduce heart failure hospitalizations. The CardioMEMs System, the most studied and established remote monitoring system, relies on a pulmonary artery implant for continuous PAP measurement. However, there are no commercially... Read More
Gender:
All
Ages:
20 years and above
Trial Updated:
11/09/2022
Locations: PIH Good Samaritan Hospital, Los Angeles, California
Conditions: Heart Failure, Pulmonary Arterial Hypertension
Boost Intentions and Facilitate Action to Promote COVID-19 Booster Take-up
Recruiting
This is a prospective randomized clinical trial evaluating how behaviorally-informed outreach text messages affect the take-up of bivalent COVID-19 booster. The investigators will test the impact of sending text reminders as well as the importance of elevating vaccination intentions, facilitating action, and their combination.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: UCLA Health Department of Medicine, Quality Office, Los Angeles, California
Conditions: COVID-19, Vaccines
Information Provision and Consistency Framing to Increase COVID-19 Booster Uptake
Recruiting
This study investigates different ways to elevate intentions to get the COVID-19 booster via text-based reminders, including providing information about the booster and leveraging the consistency principle. The proposed randomized controlled trial will examine the impact of these reminders on booster uptake.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: UCLA Health Department of Medicine, Quality Office, Los Angeles, California
Conditions: COVID-19, Vaccines
Dose-escalation Study of Safety of PBCAR19B in Participants With CD19-expressing Malignancies
Recruiting
This is a Phase 1, nonrandomized, open-label, single-dose, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of PBCAR19B in adult study participants with CD-19 expressing malignancies.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: City of Hope, Duarte, California
Conditions: CD19 Expressing Malignancies, Hematologic Malignancy
StimRouter Registry Clinical Protocol
Recruiting
This Registry study will prospectively evaluate the long-term effectiveness, safety, and tolerability of the StimRouter Neuromodulation System, along with evaluating the technical performance of StimRouter, surgical outcomes, health-related quality of life, concomitant medical use, and subject's impression of improvement.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/07/2022
Locations: University of California San Diego, La Jolla, California
Conditions: Chronic Pain, Peripheral Neuropathy, Nervous System Diseases, Peripheral Nervous System Diseases, Peripheral Nervous System Problem, Peripheral Nerve Injuries, Peripheral Nervous
MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
Recruiting
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiogra... Read More
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
11/07/2022
Locations: UCSF Orthopedic Institute, San Francisco, California
Conditions: Other Instability, Shoulder, Dislocations, Subluxations, Recurrent Dislocation of Shoulder Region