California is currently home to 5608 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Gentamicin for Junctional Epidermolysis Bullosa
Recruiting
Herlitz junctional epidermolysis bullosa (H-JEB), an incurable, fatal, inherited skin disease, is caused by loss-of-function mutations in the LAMA3, LAMB3 or LAMC2 genes, resulting in loss of laminin 332 and poor epidermal-dermal adherence. Eighty percent of H-JEB patients have LAMB3 mutations and about 95% of these are nonsense mutations. The investigators recently demonstrated that gentamicin readily induced nonsense mutation readthrough and produced full-length laminin beta3 in several nonsen... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/03/2020
Locations: University of Southern California, Los Angeles, California
Conditions: Junctional Epidermolysis Bullosa
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
Recruiting
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/04/2019
Locations: Sutter Health/Alta Bates Summitt Medical Center, Oakland, California
Conditions: Mitral Valve Insufficiency
Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele
Recruiting
The purpose of this study is to evaluate the feasibility of a fetoscopic surgical technique for antenatal correction of fetal myelomeningocele. Two surgical approaches will be utilized. The percutaneous approach will be offered to participants with a posterior placenta. The laparotomy/uterine exteriorization approach will be offered to participants regardless of placental location.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/11/2019
Locations: University of Southern California / Huntington Memorial Hospital, Los Angeles, California
Conditions: Neural Tube Defects, Spina Bifida, Myelomeningocele, Chiari Malformation
MyHeart Counts Cardiovascular Health Study
Recruiting
The MyHeart Counts Cardiovascular Health Study will utilize mobile health capabilities of smartphones and wearables to assess daily activity measures of the general population and compare these to measures of cardiovascular health risk factors and fitness. How people divide their time among exercise, sedentary behavior, and sleep all affect cardiovascular health, yet to date these have largely gone unmeasured. With the advancement of phone sensors and wearable fitness tracking devices these fact... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2019
Locations: Stanford University, Stanford, California
Conditions: Cardiovascular Health
REtroperitoneal SArcoma Registry: an International Prospective Initiative
Recruiting
Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a rare disease. Therefore, prospective analysis of high quality data is a top priority. Primary Objectives of this study are: * to prospectively collect standardized clinical data and radiological and pathological material from primary RPS patients treated with surgery at r... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/11/2019
Locations: University of Southern California (USC), Los Angeles, California
Conditions: Retroperitoneal Sarcoma
Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry
Recruiting
The objective of this study is to evaluate the procedural and clinical outcomes of patients with bicuspid aortic valve stenosis undergoing transcatheter aortic valve replacement.
Gender:
ALL
Ages:
Between 19 years and 129 years
Trial Updated:
02/07/2019
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Bicuspid Aortic Valve
Safety and Efficacy Study of OMS721 in Patients With Atypical Hemolytic Uremic Syndrome
Recruiting
The purpose of this study is to evaluate the platelet count change from baseline and safety of OMS721 in adults and adolescents with atypical hemolytic uremic syndrome (aHUS). The study will also evaluate pharmacokinetics (PK), pharmacodynamics (PD), and anti-drug antibody response (ADA).
Gender:
ALL
Ages:
12 years and above
Trial Updated:
10/17/2018
Locations: Omeros Investigational Site, Los Angeles, California
Conditions: Thrombotic Microangiopathies, Atypical Hemolytic Uremic Syndrome
Study of the TearCare System in Dry Eye Disease
Recruiting
This study is being conducted to evaluate the short-term (1 month) safety and effectiveness of a single TearCare procedure to treat adult patients with dry eye disease. NOTE: All sites have been selected for this study.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
08/15/2018
Locations: Eye Research Institute, Newport Beach, California
Conditions: Dry Eye
Impact of Unrestrictive Exercise Following Mid-Urethral Sling Surgery
Recruiting
To determine the impact of unrestricted postoperative activity on intermediate- and long-term continence outcomes of mid-urethral sling surgery in women with stress urinary incontinence. To assess the natural return to baseline activity level when patients are unrestricted following mid-urethral sling surgery with or without concomitant anterior or posterior pelvic organ prolapse repair.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Stress Urinary Incontinence
The Use of cineMRI to Evaluate Botox in Patients With Medication Refractory Overactive Bladder
Recruiting
With the goal of providing improved treatment to patients with overactive bladder symptoms (OAB), the investigators seek to apply the new technology of time-resolved (cine) MRI combined with urodynamics (UDS) to understand the exact effect of intravesical botulinum toxin on bladder physiology. The investigators will specifically aim to assess the physiological mechanism by which intravesical botulinum alleviates urgency and urge incontinence symptoms in women with OAB refractory to medical thera... Read More
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Overactive Bladder
Does Bladder Instillation Reduce Time to Discharge After Sling Surgery
Recruiting
The purpose of this randomized control trial study is to determine if intraoperative bladder instillation of fluid decreases the time to discharge after having an outpatient mid-urethral sling procedure, and to measure the cost savings of this decrease in hospital stay. Charges will be broken down between recovery room charges and discharge area, as recovery room charges are significantly higher. The investigators suspect that a shorter time in the recovery room will translate into fewer charges... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Stress Urinary Incontinence
Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
Recruiting
The purpose of this study is twofold. First, is to determine whether vancomycin is effective in the early treatment of Biliary Atresia (BA) and Primary Sclerosing Cholangitis (PSC), and if so, by what mechanism. Secondly, to characterize human intestinal microbial communities and their interactions with the host.
Gender:
ALL
Ages:
Between 2 weeks and 40 years
Trial Updated:
11/10/2016
Locations: Sacramento Pediatric Gastroenterology, Sacramento, California
Conditions: Primary Sclerosing Cholangitis, Biliary Atresia