California is currently home to 5944 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Nerve Transfer to Improve Function in High Level Tetraplegia
Recruiting
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: undergo standard of care pre- and post-op testing and study exams complete pre- and post-questionnaires undergo standard of care nerve transfer surgeries follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months attend therapy at local therapist for up to 2 years postop.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/27/2024
Locations: Stanford University, Stanford, California
Conditions: Cervical Spinal Cord Injury, Tetraplegia
A Study of AMG 355 Alone and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors
Recruiting
The primary objectives of this study are to: Evaluate the safety and tolerability of AMG 355 as monotherapy and in combination with pembrolizumab in participants with advanced solid tumors Determine the recommended phase 2 dose and the maximum tolerated dose for AMG 355 as monotherapy and in combination with pembrolizumab in participants with advanced solid tumors.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
03/27/2024
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Advanced Solid Tumors
A Study to Test Whether Avenciguat Helps People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver) Who Had Bleeding in the Esophagus or Fluid Accumulation in the Belly
Recruiting
This study is open to adults with advanced liver cirrhosis caused by hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis or other causes. People can join the study if they have high blood pressure in the portal vein (main vessel going to the liver) and bleeding in the esophagus or fluid accumulation in the belly. The purpose of this study is to find out whether a medicine called avenciguat helps people with this condition. Participants are put into 2 groups by... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/27/2024
Locations: California Liver Research Institute, Pasadena, California
Conditions: Hypertension, Portal, Liver Cirrhosis
A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis
Recruiting
The primary objective of this study is to evaluate the long-term safety of avacopan in participants with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
03/27/2024
Locations: Medvin Clinical Research, Covina, California
Conditions: Antineutrophil Cytoplasmic Antibody-associated Vasculitis
A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer
Recruiting
The purpose of this study is to assess the safety, tolerability, and preliminary efficacy of BMS-986460 in men with Metastatic Castration-resistant Prostate Cancer.
Gender:
Male
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: Stanford Cancer Center, Palo Alto, California
Conditions: Metastatic Castration-resistant Prostate Cancer
A Study to Estimate How Often Post-stroke Spasticity Occurs and to Provide a Standard Guideline on the Best Way to Monitor Its Development
Recruiting
This study will monitor patients during the first year following their stroke. Stroke is a very serious condition where there is a sudden interruption of blood flow in the brain. The main aim of the study will be to find out how many of those who experience their first-ever stroke then go on to develop spasticity that would benefit from treatment with medication. Spasticity is a common post-stroke condition that causes stiff or ridged muscles. The results of this study will provide a standar... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
03/27/2024
Locations: University Of California, Los Angeles Medical Center, Los Angeles, California
Conditions: Spasticity as Sequela of Stroke
Phase 2a Study to Assess the Efficacy and Safety of AZD4604 in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA
Recruiting
This is a Phase 2a, multicentre, randomised, placebo-controlled, double-blind, parallel-group study to evaluate the efficacy, safety and PK of AZD4604 administered BID using a dry-powder inhaler at one dose level over a 12-week Treatment period in adult participants with uncontrolled moderate-to-severe asthma.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/27/2024
Locations: Research Site, La Jolla, California
Conditions: Asthma
A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis
Recruiting
The participants of this study will have confirmed Primary Biliary Cholangitis (PBC). Participants will also have inadequate response or intolerance to ursodeoxycholic acid (UDCA) a drug used to treat PBC. PBC is a disease that progresses slowly. It causes damage to the bile ducts in the liver, leading to a build-up of bile acids which causes further damage. The liver damage in PBC may lead to scarring (cirrhosis). PBC may also be associated with multiple symptoms. Many people with PBC may re... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: GastroIntestinal BioSciences, Los Angeles, California
Conditions: Primary Biliary Cholangitis (PBC)
Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR Inhibitors
Recruiting
A Phase 2 multi-center, open-label, single arm study of nab-sirolimus in patients with well-differentiated neuroendocrine tumors (NETs) of the gastrointestinal tract, lung, or pancreas who have not received prior treatment with mTOR inhibitors
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California
Conditions: Neuroendocrine Tumors, NET, Pancreatic Neuroendocrine Tumor, Gastrointestinal Neuroendocrine Tumor, Pulmonary Neuroendocrine Tumor
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder for Bladder Cancer Treatment, MODERN Study
Recruiting
This phase II/III trial examines whether patients who have undergone surgical removal of bladder, but require an additional treatment called immunotherapy to help prevent their bladder cancer from coming back, can be identified by a blood test. Many types of tumors tend to lose cells or release different types of cellular products including their DNA which is referred to as circulating tumor DNA (ctDNA) into the bloodstream before changes can be seen on scans. Health care providers can measure t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: UC San Diego Moores Cancer Center, La Jolla, California
Conditions: Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Urothelial Carcinoma AJCC v6 and v7, Stage III Bladder Urothelial Carcinoma AJCC v6 and v7, Stage IV Bladder Urothelial Carcinoma AJCC v7
A Phase 2 Study of ONO-2808 in Patients With Multiple System Atrophy
Recruiting
This is a Phase 2, double-blind, parallel-group, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of multiple doses of ONO-2808 in patients with MSA. This is the first study of ONO-2808 in patients with MSA.
Gender:
All
Ages:
Between 30 years and 80 years
Trial Updated:
03/27/2024
Locations: The Parkinson's Movement and Disorder Institute, Fountain Valley, California
Conditions: Multiple System Atrophy (MSA)
A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer
Recruiting
This study will evaluate the efficacy and safety of inavolisib in combination with Phesgo (pertuzumab, trastuzumab, and rHuPH20 injection for subcutaneous use) compared with placebo in combination with Phesgo, as maintenance therapy, after induction therapy in participants with previously untreated HER2-positive advanced breast cancer (ABC).
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: Disney Family Cancer Center, Burbank, California
Conditions: Metastatic Breast Cancer