California is currently home to 5622 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Better Sleep Study
Recruiting
The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable target, improves depression outcomes in a subgroup of adolescents with depression and a misaligned relationship between biological circadian timing and waketime utilizing a cognitive-behavioral sleep intervention.
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/02/2025
Locations: UCSF Nancy Friend Pritzker Psychiatry Building, San Francisco, California
Conditions: Depression in Adolescence, Delayed Sleep Phase
Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy
Recruiting
This clinical trial tests how well a geriatric assessment (GA) with GA-directed treatment recommendations, compared to GA with usual care, works in identifying risk factors, reducing chemotherapy radiation toxicity and functional decline, and improving the overall quality of life in older patients with non-small cell lung cancer (NSCLC). Older patients with lung cancer undergoing chemotherapy are at an increased risk of adverse outcomes including treatment toxicity and functional and physical co... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/02/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: City of Hope Comprehensive Cancer Center, Duarte, California
Conditions: Relapsed/Refractory Non-Hodgkin Lymphoma
A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
Recruiting
The primary objective of the study is to assess the efficacy of high dose and low dose fluticasone propionate (Fp)/albuterol sulfate (ABS) integrated electronic module multidose dry powder inhaler (eMDPI) compared to ABS eMDPI in decreasing severe clinical asthma exacerbation (CAEs). Secondary Objectives: To evaluate the efficacy of Fp/ABS compared to ABS and the effect on systemic corticosteroid (SCS) exposure To evaluate the safety and tolerability of Fp/A BS The duration for each particip... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
07/02/2025
Locations: Teva Investigational Site 15685, Bakersfield, California
Conditions: Asthma
Single-tracer Multiparametric PET Imaging
Recruiting
The overarching goal of this project is to develop and evaluate a single-tracer multiparametric positron emission tomography (PET) imaging solution for simultaneous imaging of blood flow and glucose metabolism using 18F-fluorodeoxyglucose (FDG) alone. The investigators working hypothesis is that quantitative blood flow can be extracted from dynamic 18F-FDG PET data by use of tracer kinetic modeling, in addition to glucose metabolism that 18F-FDG is conventionally used for.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: UC Davis EXPLORER Molecular Imaging Center, Sacramento, California
Conditions: Healthy Subjects, Cardiovascular Disease
Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer
Recruiting
GEMINI-Hepatobiliary study will assess the efficacy, safety and tolerability of novel immunomodulators alone and in combination with other anticancer drugs in participants with specified advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Research Site, Costa Mesa, California
Conditions: Hepatocellular Carcinoma, Biliary Tract Cancer
Electrical Stimulation for the Treatment of Optic Neuropathies
Recruiting
The overall aim of this study is to see whether long-term electrical stimulation with a home-stimulation device works well and is safe for the treatment of open-angle glaucoma. Open-Angle Glaucoma is a disease where the nerves in the back of your eye die off faster than expected regardless of your eye pressure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Byers Eye Institute, Palo Alto, California
Conditions: Glaucoma, Glaucoma, Open-Angle, Optic Nerve Diseases
Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/Mem T-lymphocytes) for the Treatment of Central Nervous System Lymphoma
Recruiting
This phase I trial tests the safety, side effects, and best dose of intracerebroventricularly (ICV) administered CD19-chimeric antigen receptor (CAR) T cells in treating patients with central nervous system (CNS) lymphoma. CAR T cell therapy is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient's blood. Then the gene for a special receptor that binds to a certain protein,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Central Nervous System Lymphoma
Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies
Recruiting
This phase I trial tests the safety and side effects of leflunomide in combination with steroids in treating patients with acute graft versus host disease who have undergone done stem cell transplant for blood cancers (hematologic malignancies). Sometimes the transplanted cells from a donor can attack the body's normal cells (called graft-versus-host disease). Leflunomide and steroids are immunosuppressive drugs that work in different ways to lower the body's immune response so that the new dono... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Acute Graft Versus Host Disease, Hematopoietic and Lymphoid System Neoplasm
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
Recruiting
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).
Gender:
ALL
Ages:
Between 1 day and 17 years
Trial Updated:
07/02/2025
Locations: Children's Hospital of Los Angeles, Los Angeles, California
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
GWICTIC: NAC Mechanistic Study in Gulf War Veterans
Recruiting
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.
Gender:
ALL
Ages:
Between 47 years and 70 years
Trial Updated:
07/02/2025
Locations: VA Palo Alto Health Care System War Related Illness and Injury Study Center, Palo Alto, California
Conditions: Gulf War Syndrome
ACT1VATE: Addressing Emotional Distress to Improve Outcomes Among Diverse Adults With Type 1 Diabetes
Recruiting
This research will compare a psychological intervention ("ACT1VATE") versus diabetes self-management education and support (DSME/S; usual care) in improving clinical, behavioral, psychosocial, process, and cost outcomes among adults with poorly controlled type 1 diabetes (T1D) who are experiencing significant diabetes-related emotional distress and poor glycemic control in a real world, healthcare environment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Scripps Whittier Diabetes Institute, San Diego, California
Conditions: Type 1 Diabetes