California is currently home to 5587 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Erector Spinae Plane Blockade in Pediatric Scoliosis Surgery Patients
Recruiting
Providing effective analgesia after spinal fusion for idiopathic scoliosis remains a challenge with significant practice variation existing among high volume spine surgery centers. Even in the era of multimodal analgesia, opioids are the primary analgesics used for pain control after pediatric scoliosis surgery, but have multiple known adverse effects. The erector spinae plane block (ESPB) is a newly described fascial plane block performed by injecting local anesthetic between the erector spinae... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
04/30/2025
Locations: Lucille Packard Children's Hospital, Palo Alto, California
Conditions: Scoliosis; Juvenile, Scoliosis; Adolescence
Obstetric Placement Study Using EST
Recruiting
Combined spinal-epidural (CSE) is an established technique for providing labour analgesia to obstetric patients which provides rapid onset but unsustained analgesia. The epidural catheter can be used to extend and provide continuous pain relief, however during single-segment needle-through-needle CSE, the catheter is untested. This study aims to confirm placement of epidural catheters of anesthesia through the epidural stimulation test (EST) which was first described by the PI of the study for c... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Lucille Packard Children's Hospital, Palo Alto, California
Conditions: Obstetric Pain, Anesthesia, Local
Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors
Recruiting
This phase III trial studies how well bupropion works in reducing cancer related fatigue in cancer survivors. Cancer and its treatment can cause fatigue. Bupropion is a drug that is used to treat depression, as well as to help people quit smoking. It belongs to the family of drugs called antidepressants and works by increasing certain types of activity in the brain. Bupropion may reduce cancer-related fatigue by causing changes in inflammation and stress hormones.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Kaiser Permanente-Deer Valley Medical Center, Antioch, California
Conditions: Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Umbilical Vessel Catheterization Under ECG Monitoring and Guidance
Recruiting
Umbilical venous catheters (UVC) are typically places with poor guidance and some radiological confirmation. Misplacement of the catheter could lead to its placement in other unintended anatomical areas such as the liver or the spleen, which could be detrimental in critically-ill infants. Our study aims at using a more non-invasive means of placing and continuously monitoring catheter placement using superficial electrocardiogram (ECG) tracings.
Gender:
ALL
Ages:
Between 1 day and 45 days
Trial Updated:
04/30/2025
Locations: Lucille Packard Children's Hospital, Palo Alto, California
Conditions: Pediatric ALL
Medtronic Terminate AF Study
Recruiting
The purpose of this study is to demonstrate the safety and effectiveness of the Cardioblate iRF and CryoFlex hand held devices for the treatment of non-paroxysmal AF.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: Stanford Hospitals and Clinic, Palo Alto, California
Conditions: Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Bedside Ultrasound of Gastric Contents in Pediatric Populations
Recruiting
Perioperative aspiration of gastric contents is a rare but serious adverse event. The risk of aspiration can be estimated by perioperative evaluation of stomach contents with ultrasound using a validated technique and scoring system. A lack of knowledge or familiarity is frequently cited by anesthesia providers as a rationale for not performing perioperative ultrasound assessments. The purpose of this study is to determine whether novice ultrasonography users (medical students, undergraduates, o... Read More
Gender:
ALL
Ages:
Between 2 years and 60 years
Trial Updated:
04/30/2025
Locations: LPCH/SHC, Stanford, California
Conditions: Gastric Contents
Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer
Recruiting
The purpose of this research study is to evaluate epacadostat when given with routine radiation therapy and chemotherapy (capecitabine and oxaliplatin) to treat rectal cancer before routine surgery is performed to remove the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: University of California Irvine - Chao Family Comprehensive Cancer Center, Orange, California
Conditions: Rectal Cancer
Measuring Surgical Recovery After Radical Cystectomy
Recruiting
The intent of this study is to establish a registry of post-surgical outcomes in patients undergoing radical cystectomy at MD Anderson Cancer Center and the collaborating institutions. The goals of this initiative are to obtain a detailed baseline of multiple patient-reported outcomes (PRO) and clinician-reported outcomes (CRO) as well as various presenting conditions associated with them, so that future quality improvement interventions can be evaluated accurately as to their relative contribut... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: University of California - San Francisco, San Francisco, California
Conditions: Bladder Cancer
An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver Damage
Recruiting
This a phase 1, open label, single dose, parallel cohort study to determine the pharmacokinetics (PK) of study drug (ESK-001) in healthy volunteer participants, and participants with mild, moderate, and severe hepatic impairment.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/29/2025
Locations: Orange County Research Center, Lake Forest, California
Conditions: Hepatic Impairment
Health Care Transition Readiness Short-Form Video Intervention
Recruiting
The goal of this clinical trial is to assess whether social-media style short-form health education videos can increase health care transition readiness, self-efficacy, emotional well-being, health literacy, and appointment attendance, compared with publicly available health education resources in adolescents with chronic illnesses. The main question it aims to answer is: -Hypothesize social media intervention will increase health care transition readiness, self-efficacy, emotional well-being,... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
04/29/2025
Locations: Children Hospital Los Angeles, Los Angeles, California
Conditions: Health Care Transition Readiness, Health Literacy, Self Efficacy, Emotional Wellbeing, Appointment Attendance
Management of Acute Tinnitus With Migraine Medications
Recruiting
Tinnitus represents one of the most common and distressing otologic problems, and it causes various somatic and psychological disorders that interfere with the quality of life. Despite too many research projects on finding the mechanism of tinnitus, its pathophysiology remains poorly understood. It is well understood that many factors, such as poor education, lower income, or occupational, and recreational activity associated with high noise exposure, influence the prevalence and risk of tinnitu... Read More
Gender:
ALL
Ages:
Between 25 years and 85 years
Trial Updated:
04/29/2025
Locations: University of California, Irvine Medical Center ENT Clinic (Pavilion 2), Orange, California
Conditions: Tinnitus
Siegel™ Transcatheter Aortic Valve Replacement System (TAVR) Early Feasibility Study
Recruiting
The Siegel™ Transcatheter Aortic Valve (TAVR) early feasibility study objective is to assess the acute and long-term safety and feasibility of the Siegel TAVR device in adult subjects with symptomatic, severe native aortic stenosis eligible for the transcatheter aortic valve replacement.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/29/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Aortic Stenosis Symptomatic