California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Derm-Maxx in Patients with Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone
Recruiting
This randomized controlled study evaluates the adjuvant use of Derm-Maxx in patients with diabetic foot ulcers
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2025
Locations: Premium Podiatry, Encino, California
Conditions: Diabetic Foot Ulcer
A Study of LM-24C5 For Advanced Solid Tumors
Recruiting
To assess the safety and tolerability, obtain the recommended phase 2 dose (RP2D)/optimal biologic dose (OBD) and/or Maximum Tolerated Dose (MTD) for LM-24C5 in subjects with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2025
Locations: University of Southern California (USC) - Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Advanced Solid Tumor
Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Recruiting
This phase I trial studies the side effects and best dose of mosunetuzumab when given together with polatuzumab vedotin and lenalidomide in treating patients with diffuse large B-cell lymphoma (DLBCL) that has come back after a period of improvement (relapsed) or that has not responded to previous treatment (refractory). Mosunetuzumab and polatuzumab vedotin are monoclonal antibodies that may interfere with the ability of cancer cells to grow and spread. Polatuzumab, linked to a toxic agent call... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2025
Locations: City of Hope Comprehensive Cancer Center LAO, Duarte, California
Conditions: Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma, Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
Research on Equity in Abortion Care by TeleHealth
Recruiting
This study will examine the ways in which telehealth for reproductive healthcare affects timing, costs, and follow-up care; whether telehealth reaches people in areas with greater health inequities; and the attributes of telehealth that patients want. Study surveys will be administered to interested, eligible participants: 2,000 patients seeking abortion care will complete the study, comprising of 2 groups: patients seeking medication abortion care either (1) in-person or (2) via telehealth. Thi... Read More
Gender:
ALL
Ages:
Between 14 years and 64 years
Trial Updated:
03/07/2025
Locations: Advancing New Standards in Reproductive Health (ANSIRH), Oakland, California
Conditions: Abortion in First Trimester, Abortion Early, Abortion; Attempted
Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia
Recruiting
This early phase I trial tests the safety and side effects of allogeneic CMV-specific CD19-CAR T cells plus CMV-MVA vaccine and how well it works in treating patients with high-risk acute lymphoblastic leukemia after a matched related donor (allogeneic) hematopoietic stem cell transplant (alloHSCT). Chimeric antigen receptor (CAR) T-cell therapy is a type of treatment in which T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Acute Lymphoblastic Leukemia
Reliability of the Samsung Galaxy for the Detection of Moderate to Severe Obstructive Sleep Apnea
Recruiting
The study will test the reliability of the Samsung Galaxy for the Detection of Moderate to Severe Obstructive Sleep Apnea (OSA)
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/07/2025
Locations: Stanford University, Palo Alto, California
Conditions: Obstructive Sleep Apnea of Adult
OPtilume™ BPH Catheter SystEm for Treatment of Men eXperiencing Symptomatic BPH
Recruiting
APEX is a prospective multi-site registry of real-world experience with the Optilume™ BPH Catheter System for treatment of men experiencing symptomatic BPH.
Gender:
MALE
Ages:
All
Trial Updated:
03/07/2025
Locations: Golden State Urology, Sacramento, California
Conditions: Benign Prostatic Hyperplasia
A Study to Learn More About How Well BAY 2927088 Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Human Epidermal Growth Factor Receptor 2 (HER2)
Recruiting
Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutations. Advanced NSCLC is a group of lung cancers that have spread to nearby tissues or to other parts of the body or that are unlikely to be cured or controlled with currently available treatments. HER2 is a protein that helps cells to grow and divide. A damage (also called mutation) to the building... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: Patty & George Hoag Cancer Center, Newport Beach, California
Conditions: Advanced Non-small Cell Lung Cancer, HER2 Mutation
PTT-936 Alone or in Combination in Patients With Locally Advanced or Metastatic Solid Tumors
Recruiting
This Phase 1/2a study will explore the safety and efficacy of PTT-936, an Alpha Kinase 1 (ALPK1) activator, used alone or in combination with anti-PD-1/L1 therapy in patients with locally advanced or metastatic solid tumors. The study is divided into two parts: Phase 1 (Part A) focuses on determining the pharmaceutically active dosage range and evaluating the safety profile of PTT-936 when administered as a monotherapy. Phase 2a (Part B) will assess the safety and efficacy of PTT-936 combined wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: Precision NextGen Oncology and Research Center, Beverly Hills, California
Conditions: Locally Advanced or Metastatic Solid Tumors
Study to Evaluate NRCT-101SR in Pediatric Subjects with ADHD
Recruiting
To evaluate the efficacy and safety of NRCT-101SR compared to placebo in subjects 13-17 years of age with ADHD
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
03/07/2025
Locations: Advanced Research Center, Inc, Anaheim, California
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
Platform Clinical Study for Conquering Scleroderma
Recruiting
The goal of this clinical trial is to test efficacy of different investigational products (IPs) compared with placebo on the change from baseline to the end of the treatment period at Week 52 in lung capacity in participants with Interstitial Lung Disease Secondary to Systemic Sclerosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: Keck School of Medicine at USC Medical Center, Los Angeles, California
Conditions: Interstitial Lung Disease Due to Systemic Disease, Scleroderma
A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer
Recruiting
This is a Phase III, 2-arm, randomised, open-label, multicentre, global study assessing the efficacy and safety of neoadjuvant Dato-DXd plus durvalumab followed by adjuvant durvalumab with or without chemotherapy compared with neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab with or without chemotherapy in participants with previously untreated TNBC or hormone receptor-low/HER2-negative breast cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: Research Site, Bakersfield, California
Conditions: Breast Cancer