California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Metformin for Pulmonary Hypertension HFpEF
Recruiting
The main objective of this study is to determine the clinical efficacy of metformin versus placebo and the therapeutic response with regards to functional capacity and hemodynamics in PH-HFpEF.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: UCSF Medical Center, San Francisco, California
Conditions: Pulmonary Hypertension, Heart Failure
Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM Subjects
Recruiting
The purpose of this study is to assess the safety and tolerability of VBI-1901 in subjects with recurrent malignant gliomas (glioblastoma, or GBM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: University of California, Irvine, Irvine, California
Conditions: Glioblastoma Multiforme
Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors
Recruiting
The purpose of this study is to assess the safety, tolerability, and immunogenicity of mRNA-4157 alone and in combination in participants with solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: Angeles Clinic and Research Institute, Los Angeles, California
Conditions: Solid Tumors
Improving Bladder Function in SCI by Neuromodulation
Recruiting
This trial will investigate the safety and utility of spinal cord neuromodulation to improve urinary bladder function in the context of spinal cord injury.
Gender:
MALE
Ages:
Between 18 years and 45 years
Trial Updated:
03/07/2025
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Spinal Cord Injury
Optimizing Nutrition and Milk (Opti-NuM) Project
Recruiting
Early nutrition critically influences growth, neurodevelopment and morbidity among infants born of very low birth weight (VLBW), but current one-size-fits-all feeding regimes do not optimally support these vulnerable infants. There is increasing interest in "precision nutrition" approaches, but it is unclear which Human Milk (HM) components require personalized adjustment of doses. Previous efforts have focused on macronutrients, but HM also contains essential micronutrients as well as non-nutri... Read More
Gender:
ALL
Ages:
Between 1 hour and 21 days
Trial Updated:
03/06/2025
Locations: Stanford University, Palo Alto, California
Conditions: Very Low Birth Weight Baby, Early Nutrition and the Preterm Infant, Nutritional Requirements, Human Milk Fortification, Human Milk Microbiome, Human Milk Feeding, Human Milk Nutrition, Growth & Development
Response to an Investigational Device in Patients with Restless Legs Syndrome
Recruiting
This study assesses the tolerability, safety, and impact of an investigational medical device on restless legs syndrome symptoms. The IRB has established that the investigational device is non-significant risk.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/06/2025
Locations: Noctrix Health Headquarters, Pleasanton, California
Conditions: Restless Legs Syndrome
Using CTA Measures to Define Cardiac Risk In NFL Alumni
Recruiting
The GAMEFILM Registry is a post-market, multi-center, data collection study assessing the presence of CAD in NFL alumni.
Gender:
ALL
Ages:
All
Trial Updated:
03/06/2025
Locations: Stanford, Stanford, California
Conditions: Coronary Artery Disease (CAD), Heart Disease, Coronary Atherosclerosis
Role of Transposable Elements in Septic Immune Aging
Recruiting
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction, Sepsis, Severe, Sepsis at Intensive Care Unit, Sepsis, Severe Sepsis and Septic Shock, Sepsis, Septic Shock
Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S02)
Recruiting
This clinical trial evaluates the use of self-collected vaginal samples for human papillomavirus (HPV) testing in patients referred for a colposcopy and/or cervical excisional procedures to improve cervical cancer prevention. HPV is a common virus which usually causes infections that last only a few months, but sometimes can last longer. It is known to cause a variety of cancers including cancer of the cervix. Even though there are ways to detect cervical cancer early, many individuals do not un... Read More
Gender:
FEMALE
Ages:
25 years and above
Trial Updated:
03/06/2025
Locations: UCSF Medical Center-Parnassus, San Francisco, California
Conditions: Cervical Carcinoma, Human Papillomavirus Infection
Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308)
Recruiting
The primary objective of this study is to evaluate the safety and tolerability of subcutaneous (SC) tarlatamab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Extensive Stage Small Cell Lung Cancer
Toddlers' Responses to Strangers
Recruiting
The study will assess if toddlers show differences in stranger wariness according to race, temperament, social network diversity, and neighborhood diversity.
Gender:
ALL
Ages:
Between 13 months and 24 months
Trial Updated:
03/06/2025
Locations: Social Science 2 Building, Santa Cruz, California
Conditions: Social Behavior
Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP
Recruiting
Rates of bacterial sexually transmitted infections (STIs) are rising globally, demanding innovative interventions beyond the scope of current efforts to prevent STIs. The United States Doxycycline Post-exposure Prophylaxis (DoxyPEP) Study has demonstrated the efficacy of doxycycline post-exposure prophylaxis (PEP) among men who have sex with men and transgender women; but puzzlingly, doxycycline PEP was found ineffective in cisgender women in the Kenyan doxycycline Post-Exposure Prophylaxis (dPE... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: University of California, San Francisco/San Francisco General Hospital, San Francisco, California
Conditions: Sexually Transmitted Diseases, Bacterial