California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Neural Correlates of Real World Spatial Navigation in Humans
Recruiting
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Gender:
ALL
Ages:
Between 12 years and 70 years
Trial Updated:
04/23/2025
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Memory, Delayed
Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study
Recruiting
This phase II trial investigates how well lisinopril may work in preventing the progression of non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition where there is an accumulation of fatty cells in the liver. NAFLD increases a person's risk of developing liver cancer. Liver fibrosis is the common finding of chronic liver diseases leading to reduced liver function. Lisinopril is a medication that is commonly used to treat high blood pressure. Lisinopril may help to decrease liver fibros... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Nonalcoholic Steatohepatitis, Hepatocellular Carcinoma
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
Recruiting
This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the safety and efficacy of AGN-193408 SR in participants with open-angle glaucoma or ocular hypertension
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Global Research Management /ID# 241699, Glendale, California
Conditions: Open-angle Glaucoma, Ocular Hypertension
Impact of Sinus Surgery on Individuals With Cystic Fibrosis
Recruiting
This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/23/2025
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Chronic Rhinosinusitis (Diagnosis), Cystic Fibrosis
Pulmonary Hemodynamics During Exercise - Research Network
Recruiting
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of California, Los Angeles, Lung & Heart-Lung Transplant and Pulmonary Hypertension Programs, David Geffen School of Medicine, Los Angeles, California
Conditions: Pulmonary Circulation Diseases
Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis
Recruiting
The exploratory objective of this pilot study is to evaluate the feasibility and safety of an enhanced recovery protocol that will allow adult patients to be discharged to home on an oral antibiotic regimen for three days following a laparoscopic appendectomy for complicated appendicitis. Feasibility will be determined by high compliance and adherence of patients to the postoperative instructions, while safety will be assessed by the incidence of postoperative infectious complications and requir... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Appendicitis Acute, Appendicitis Perforated, Appendicitis With Perforation, Appendicitis Suppurative, Appendicitis Gangrenous
Huntington's Disease Biobank: Advancing Remote Monitoring and Deep Phenotyping
Recruiting
This observational study aims to identify novel biomarkers of disease onset and progression in Huntington's disease by integrating remote monitoring with fluid biomarkers. Using video-based computer vision and mobile app-based cognitive assessments combined with machine learning algorithms, we aim to develop markers that can be used by Huntington's disease patients at home. Using machine learning to analyze videos of movement will capture the movements with an accuracy that will be as good as s... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/22/2025
Locations: Stanford University, Palo Alto, California
Conditions: Huntington Disease
Lemborexant in Delayed Sleep Phase Syndrome
Recruiting
The purpose of the study is to evaluate whether Lemborexant is more effective than placebo in shortening sleep onset latency in patients with delayed sleep phase syndrome (both type 1 and type 2). This will be tracked using sleep logs as well as actigraphy. In this 2-year study, the investigators will examine if Lemborexant administered 5-10 mg nightly taken at desired bedtime (at least 2 hours prior to self-reported sleep onset habitual time) can improve the symptoms of Delayed Sleep Phase Syn... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Delayed Sleep Phase Syndrome
A Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Elismetrep (K-304) in the Treatment of Migraine
Recruiting
This is a double-blind, randomized, multicenter, outpatient evaluation of the safety and efficacy of elismetrep as compared to placebo in the treatment of moderate or severe migraine.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/22/2025
Locations: Hope Clinical Research, Canoga Park, California
Conditions: Acute Migraine
HPV Ends Here: Increasing Uptake of the HPV Vaccine
Recruiting
Develop, implement, and evaluate a culturally tailored multilevel intervention to increase uptake of the HPV vaccine among eligible patients ages 10-12 of the University of California, Davis Health Community Physician (UCDH CP) primary care practices using a randomized controlled trial design.
Gender:
ALL
Ages:
Between 10 years and 12 years
Trial Updated:
04/22/2025
Locations: University of California Davis Health, Sacramento, California
Conditions: HPV Vaccine
A Phase 1/2, Dose-Exploration Study to Evaluate the Safety and Efficacy of BEAM-301 in Patients With Glycogen Storage Disease Type Ia (GSDIa)
Recruiting
This is a Phase 1/2, multicenter, open-label, single-ascending-dose study to evaluate the safety, tolerability, and efficacy of BEAM-301 in adult patients with GSDIa homozygous or compound heterozygous for the G6PC1 c.247C\>T (p.R83C) variant and to determine the optimal biological dose.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Clinical Study Site, Orange, California
Conditions: Glycogen Storage Disease Type Ia
Safety and Efficacy of EIK1001-006 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.
Recruiting
The study is for patients with advanced melanoma who are eligible for standard therapy with Pembrolizumab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: The Oncology Institution of Hope and Innovation, Los Angeles, California
Conditions: Advanced Melanoma