California is currently home to 5626 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease
Recruiting
A phase 2, double-blind, randomized, placebo-controlled clinical trial to evaluate the safety and efficacy of Allopregnanolone as a regenerative therapeutic for Alzheimer's disease.
Gender:
ALL
Ages:
Between 55 years and 80 years
Trial Updated:
05/06/2025
Locations: ATP Clinical Research, Costa Mesa, California
Conditions: Alzheimer Dementia, Late Onset Alzheimer Disease, Neurodegenerative Diseases
Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD
Recruiting
This study will evaluate the efficacy and safety of SPN-812 (viloxazine extended release) in children 4 to 5 years of age with ADHD.
Gender:
ALL
Ages:
Between 48 months and 69 months
Trial Updated:
05/06/2025
Locations: Advanced Research Center (ARC), Inc., Anaheim, California
Conditions: Attention-Deficit/Hyperactivity Disorder
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
Recruiting
RADAR is a multicentre, international, randomised, open-label phase III clinical trial composed of 2 trials running in parallel. Trial 1 will be led and sponsored by University College London (UCL) and conducted in Europe and Australia/New Zealand. Trial 2 will be led by the Canadian Cancer Trials Group (CCTG) and conducted in North America, with CCTG the regulatory sponsor in Canada, and University of Miami the regulatory sponsor and IND holder in the US. Datasets from Trial 1 and Trial 2 will... Read More
Gender:
ALL
Ages:
Between 16 years and 69 years
Trial Updated:
05/06/2025
Locations: Stanford University - (Stanford Cancer Institute), Stanford, California
Conditions: Hodgkin Lymphoma
Project Talk Trial: Engaging Underserved Communities in End-of-life Conversations
Recruiting
Compared to the general population, individuals from underserved communities are more likely to receive low quality end-of-life care and unwanted, costly and burdensome treatments due in part to a lack of advance care planning (ACP; the process of discussing wishes for end-of-life care with loved ones/clinicians and documenting them in advance directives). This study will use existing, trusted, and respected social networks to evaluate two conversation-based tools intended to engage underserved... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Promotores y Promotoras, Santa Paula, California
Conditions: Advance Care Planning, Advance Directives, Terminal Illness, Chronic Illness, Communication
Prescreening Protocol to Enroll in Food Allergy Clinical Studies at a Single Site
Recruiting
This is a protocol for prescreening of participants who would like to be in clinical studies in our Center at Stanford.
Gender:
ALL
Ages:
Between 1 week and 90 years
Trial Updated:
05/06/2025
Locations: The Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, California
Conditions: Food Allergy
A Novel Multiplex ELISA Assay for Evaluating Patients With Gross Hematuria for Bladder Cancer
Recruiting
To improve upon the non-invasive detection of BCa by further validating a multiplex ELISA assay directed at a BCa-associated diagnostic signature in voided urine samples of patients with gross hematuria.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Bladder Cancer
A Study of 2 Doses of Ritlecitinib in People 12 Years of Age and Older With Alopecia Areata
Recruiting
The purpose of the study is to learn about the safety and effects of the study medicine (called ritlecitinib) for the treatment of alopecia areata. Alopecia areata is a disease that causes hair loss on the scalp, face, and areas of the body. Ritlecitinib is approved in many countries at a dose of 50 mg (milligram) taken by mouth once a day for the treatment of patients 12 years and older with severe alopecia areata. This study will look at both the 50 mg dose and a 100 mg dose. This study is s... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
05/05/2025
Locations: Southern California Clinical Research, Santa Ana, California
Conditions: Alopecia Areata
Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department
Recruiting
The overarching goal of this proposal is to integrate patient social risk information into an existing electronic health record (EHR)-based clinical decision support (CDS) tool (CDSv1) to facilitate emergency department (ED)-initiated, social risk-informed opioid use disorder (OUD) medication treatment and ultimately improve treatment adherence and follow up. The investigators will evaluate the feasibility and acceptability of the social care-enhanced CDS tool, CDSv2, (compared to CDSv1) at a si... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Opioid Use Disorder, Social Determinants of Health (SDOH)
A Study to Prevent Infantile Spasms Relapse
Recruiting
After initially successful treatment, many children with infantile spasms unfortunately have a relapse, and relapse is linked to poor long-term outcomes such as autism and other forms of epilepsy. The aim of this study is to determine if treatment with low-dose prednisolone is safe, well tolerated, and effective in reducing the risk of relapse.
Gender:
ALL
Ages:
Between 2 months and 18 months
Trial Updated:
05/05/2025
Locations: UCLA, Los Angeles, California
Conditions: Infantile Spasms, Infantile Epileptic Spasms Syndrome, West Syndrome
A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies
Recruiting
The goal of this clinical trial is to learn if KQB198 works to treat advanced hematologic malignancies in adults. It will also learn about the safety of KQB198. The main questions it aims to answer are: * What is the safe dose of KQB198 by itself or in combination with other anti-cancer drugs? * Does KQB198 alone or in combination with other anti-cancer drugs decrease the size of the tumor? * What happens to KQB198 in the body? Participants will: * Take KQB198 daily, alone or in combination w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: University of California, San Francisco (UCSF), San Francisco, California
Conditions: Hematologic Malignancies, Adult
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
Recruiting
This is a non-inferiority patient-centered and pragmatic comparative-effectiveness pregnancy randomized controlled trial (RCT) with postpartum maternal and child follow-up through 2 years of 1,572 individuals with gestational diabetes mellitus (GDM) randomized to oral metformin versus injectable insulin. This study will determine if metformin is not inferior to insulin in reducing adverse pregnancy outcomes, is comparably safe for exposed individuals and children, and if patient-reported factor... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Gestational Diabetes Mellitus, Pregnancy, High Risk
TEMPUS ARIES: A Biobank Registry Platform Study in Oncology
Recruiting
This study is a non-interventional, multicenter, multicohort evaluation of participants with cancer who will undergo longitudinal plasma ctDNA biomarker profiling at specific time points in addition to standard of care therapy.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/05/2025
Locations: PIH Health Whittier Hospital & PIH Health Physicians, Whittier, California
Conditions: Cancer