California is currently home to 5597 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Effect of Daily Mixed Spice Consumption on Memory Function
Recruiting
The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradual and progressive decline in cognitive function. Recent research has indicated that various spices may hold the key to enhancing brain health and combating the effects of aging on cognitive abilities. The hypothesis is that a mixture of spices, acknowledged for their reported memory protection potential, may yield a more potent beneficial effect on memory function than a single... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
03/20/2025
Locations: UCLA Center for Human Nutrition, Los Angeles, California
Conditions: Memory, Cognitive Function
Fermented Vegetables and Gut Microbiome Pilot Study
Recruiting
The purpose of this research is to determine the effect of fermented vegetable consumption on LAB abundance and tolerability of the intervention in young healthy people before conducting a full RCT with older participants.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/20/2025
Locations: USDA Western Human Nutrition Research Center, Davis, California
Conditions: Fermented Vegetable Intake, Fermented Vegetable Acceptability, Gut Health, Gut Microbiome, Gastrointestinal Immune Function, Microbiome
Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder
Recruiting
The ADAPT-ED study is a two-stage, sequential multiple assignment randomized trial (SMART) to inform the development of an adaptive intervention that is optimally effective in increasing long-term buprenorphine use for adults presenting to the ED with probable opioid use disorder (OUD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: Arrowhead Regional Medical Center, Colton, California
Conditions: Opioid Use Disorder
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
Recruiting
X-NOVA2 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants diagnosed with Major Depressive Disorder (MDD)
Gender:
ALL
Ages:
Between 18 years and 74 years
Trial Updated:
03/20/2025
Locations: Excell Research Inc., Oceanside, California
Conditions: Major Depressive Disorder
Benefits of Choir for Older Adults with Unaddressed Hearing Loss (WP2)
Recruiting
Unaddressed age-related hearing loss is highly prevalent among older adults, typified by negative consequences for speech-in-noise perception and psychosocial wellbeing. There is promising evidence that group singing may enhance speech-in-noise perception and psychosocial wellbeing. However, there is a lack of robust evidence, primarily due to the literature being based on small sample sizes, single site studies, and a lack of randomized controlled trials. Hence, to address these concerns, this... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/20/2025
Locations: Brain and Creativity Institute, University of Southern California, Los Angeles, California
Conditions: Hearing Loss, Age-Related, Speech Intelligibility, Psychosocial Functioning
A Study of Andecaliximab in Participants with Fibrodysplasia Ossificans Progressiva (FOP)
Recruiting
This study is researching an experimental drug called andecaliximab. The study will include pediatric and adult patients with fibrodysplasia ossificans progressiva (FOP). The study will evaluate how safe and effective andecaliximab is in patients with FOP. The study is looking at several research questions, including: * Safety of andecaliximab in participants with FOP * Whether andecaliximab reduces the number of new heterotopic bone lesions (Heterotopic Ossification; HO) * Whether andecalixim... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/20/2025
Locations: University of California San Francisco (UCSF), San Francisco, California
Conditions: Fibrodysplasia Ossificans Progressiva
Motivation for IV Alcohol Self-Administration in Humans
Recruiting
The goal of this translational study is to understand different reasons why people between the ages of 21 and 65 with alcohol use disorder are motivated to self-administer alcohol. The main questions it aims to answer are: * How does a person's desire for a reward affect their motivation to self-administer alcohol? * How does a person's emotions affect their motivation to self-administer alcohol? * How does a person's cognitive functioning affect their motivation to self-administer alcohol? Pa... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
03/20/2025
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Alcohol Use Disorder
Purified Exosome Product (PEP) Injected Into the Hypodermis
Recruiting
This clinical trial aims to characterize the safety, tolerability, and histological profile of PEP (Purified Exosome Product) when injected into the hypodermis of healthy adults. The main questions this study aims to answer are: Is PEP safe and tolerable when injected into the hypodermis of healthy adults? Subjects will serve as their own control and researchers will compare PEP to Control to see if PEP is safe.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/20/2025
Locations: Clinical Testing of Beverly Hills, Encino, California
Conditions: Safety
KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Subjects With Refractory Generalized Myasthenia Gravis
Recruiting
A Study of the Anti-CD 19 Chimeric Antigen Receptor T Cell Therapy for Subjects with Myasthenia Gravis
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/20/2025
Locations: University of California, Irvine, Orange, California
Conditions: Myasthenia Gravis, Generalized Myasthenia Gravis
High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients
Recruiting
Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients. However, these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV). Recent studies have investigated two strategies to overcome poor immune responses in SOT recipients: (1) administration of high-dose (HD)-IIV compared to SD-IIV and (2) two doses of SD-IIV compared to one dose of SD-IIV in the same influenza season. One study compared HD-IIV vs. SD-IIV in adult SOT rec... Read More
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
03/20/2025
Locations: Stanford University, Stanford, California
Conditions: Immunization; Infection, Transplantation Infection, Influenza
Study With Various Immunotherapy Treatments in Participants With Lung Cancer
Recruiting
The purpose of this study is to assess the objective response rate (ORR) of immunotherapy-based combination therapy and to assess the safety and tolerability of immunotherapy-based combination therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: University of California San Diego (UCSD), La Jolla, California
Conditions: Advanced Non-Small Cell Lung Cancer
Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects
Recruiting
All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms: lifestyle intervention (n=24), senolytics (n=24), or placebo (n=24).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Obesity, Healthy Lifestyle