California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Real-Time Levodopa Level Monitoring in Parkinson Disease
Recruiting
This project aims to develop a minimally invasive sensor device to monitor levodopa levels in real time. We will test the accuracy, tolerability, and safety of this device in people with Parkinson disease.
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
02/10/2025
Locations: University of California San DIego, San Diego, California
Conditions: Parkinson Disease
Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery
Recruiting
The phase I/II trial studies the side effects and best dose of panitumumab-IRDye800 in diagnosing participants with malignant glioma who undergo surgery. Panitumumab-IRDye800 can attach to tumor cells and make them more visible using a special camera during surgery, which may help surgeons better distinguish tumor cells from normal brain tissue and identify small tumors that cannot be seen using current imaging methods.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2025
Locations: Stanford University School of Medicine, Palo Alto, California
Conditions: Malignant Brain Neoplasm, Malignant Glioma
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
Recruiting
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF) severity categories based on the American Society of Echocardiography's (ASE) 4-category scale. The software analyzes continuous ECG waveform data acquired by the FDA-cleared Peerbridge COR® ECG Wearable Monitor, an ambulatory patch device designed for use during daily act... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/09/2025
Locations: Orange County Heart Institute, Orange, California
Conditions: Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement, Conduction Defect, Heart Failure, Valvular Heart Disease, Ischemic Heart Disease, Cardiotoxicity, Myocardial Infarction, Dilated Cardiomyopathy, HFrEF - Heart Failure with Reduced Ejection Fraction, HFpEF - Heart Failure with Preserved Ejection Fraction, Syncope, Remodeling, Cardiac
A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes
Recruiting
This is a Phase 2 randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy and safety of AK117 or placebo, combined with azacitidine in patients with newly diagnosed higher-risk myelodysplastic syndromes (HR-MDS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/09/2025
Locations: UCLA Ronald Reagan Medical Center, Los Angeles, California
Conditions: Higher-risk Myelodysplastic Syndromes
Feasibility Usability & Acceptability Study: Symptom Reporting by Children Adolescents & Young Adults w/Cancer
Recruiting
The purpose of this project is to pilot test an electronically delivered symptom assessment tool Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (Ped-PRO-CTCAE), completed by children/adolescents and young adults (AYAs) and caregivers and shared with their clinicians during an outpatient clinic visit, in preparation for a future test of intervention efficacy.
Gender:
ALL
Ages:
Between 7 years and 21 years
Trial Updated:
02/07/2025
Locations: Stanford University, Palo Alto, California
Conditions: Adolescent Behavior, Pediatric Cancer, Oncology
Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates
Recruiting
The CLEAN (ChLorine to reduce Enteric and Antibiotic resistant infections in Neonates) cluster randomized controlled trial in western Kenya will evaluate the impact of a multi-component chlorination intervention in health care facilities on maternal and neonatal health. Intervention facilities will receive a passive chlorination technology for water supply treatment and a reliable supply of sodium hypochlorite disinfectant. Both intervention and treatment facilities will receive infection preven... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/07/2025
Locations: University of California, Berkeley, Berkeley, California
Conditions: Sepsis, Neonatal Mortality, Antibiotic Resistant Infection, Enteric Infections, Serious Bacterial Infection
TriCalm Hydrogel® in the Treatment of Immunotherapy-Related Pruritus
Recruiting
This is a phase 2, randomized, open-label, single-center study that will assess the efficacy of TriCalm Hydrogel®, a topical gel containing strontium, for treating pruritus related to immune checkpoint inhibitors (ICIs).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2025
Locations: University of California San Diego, La Jolla, California
Conditions: Immunotherapy-related Pruritus
Elranatamab in Relapsed/Refractory Multiple Myeloma
Recruiting
This study evaluates the efficacy of elranatamab alone in patients with relapsed and/or refractory Multiple myeloma who has previously received 1 to 3 combinations of treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2025
Locations: University of California San Diego, La Jolla, California
Conditions: Multiple Myeloma
Cryoablation and Arterial Infusion of SD-101 in Combination with Durvalumab and Tremelimumab
Recruiting
The goal of this Phase 1b clinical trial is to evaluate the safety and efficacy of cryoablation and hepatic arterial administration of SD-101 in participants with advanced hepatocellular carcinoma. After this procedure, participants will be treated with tremelimumab and durvalumab every 4 weeks (STRIDE regimen).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2025
Locations: University of California, San Diego, San Diego, California
Conditions: Hepatocellular Carcinoma
Optimizing an Integrated Mind and Body Treatment for Insomnia: The SLEEPS Study
Recruiting
This single-arm feasibility trial will provide digital cognitive behavioral therapy for insomnia (CBT-I) and passive body heating (PBH) sessions using a sauna blanket over a 9-week treatment period to adults aged 18 years or older with insomnia disorder.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Insomnia Disorder
Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease
Recruiting
This research study is designed to assess the prevalence of specific antibodies and inflammatory cytokines in adult and pediatric participants with CGD.
Gender:
ALL
Ages:
All
Trial Updated:
02/07/2025
Locations: Home-based telemedicine, Sacramento, California
Conditions: Chronic Granulomatous Disease (CGD)
Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults with Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization
Recruiting
This is a first-in-human, Phase 1b/2a, open-label, dose-escalation study of a single treatment course consisting of multiple intradetrusor injections of EG110A in male and female adult participants with Neurogenic Detrusor Overactivity (NDO)-related incontinence following Spinal Cord Injury (SCI), who have persistent incontinence after standard of care therapy and who perform Clear Intermittent Catheterization (CIC) on a regular basis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/07/2025
Locations: Rancho Los Amigos National Rehabilitation Center, Downey, California
Conditions: Neurogenic Detrusor Overactivity, Spinal Cord Injuries