California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Microbiome, Anxiety and Cognitive Orientation Study
Recruiting
Mounting evidence shows that the gut microbiome plays an important role in communication within the gut-brain axis. However, the relationship between gut microbiota and their influence on anxiety is still not fully understood. Recent studies on mice found a specific microbe-produced molecule, 4-ethylphenyl sulfate (4EPS), can induce anxious behavior. 4EPS is produced by gut microbes in mice and humans. Research suggests higher 4EPS levels may strongly be associated with anxiety levels. However,... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/12/2022
Locations: Endominance Inc., Irvine, California
Conditions: Anxiety, Microbiome, Mood Disorders, Neurodegeneration, Depression
Evaluating Efficacy of GuessWhat Mobile App Therapy for Children With Autism
Recruiting
The following study aims to understand the efficacy of the mobile game platform, GuessWhat, in delivering behavioral therapy to children with Autism Spectrum Disorder (ASD). GuessWhat is a mobile application (available for free for iOS and Android) which contains a suite of games: pro-social charades, emotion guessing, and quiz. Participant families will use their personal smartphones to download the app and play it with their child according to a predetermined regimen.
Gender:
All
Ages:
Between 3 years and 12 years
Trial Updated:
12/12/2022
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
Yersinia Pestis Lateral Flow Immunoassay for Blood Samples
Recruiting
Plague is a deadly but highly treatable disease caused by the bacterium Y. pestis. Due to the historical development of Y. pestis as a bioweapon by several nation states, it is listed by the US as a potential bioweapon that could be used against US warfighters. Although this bacterium is ecologically established worldwide, it mostly affects impoverished people who live in rural low-resource areas of Madagascar. Plague is acquired directly from bites of infected fleas but, if left untreated, it c... Read More
Gender:
All
Ages:
Between 5 years and 75 years
Trial Updated:
12/12/2022
Locations: US Naval Health Research Center, San Diego, California
Conditions: Plague, Plague, Bubonic, Plague, Pneumonic, Yersinia Pestis Plague, Yersinia Pestis; Bubo, Yersinia Pestis; Pneumonia, Yersinia Sepsis, Yersinia Pestis Infection, Bubo; Yersinia Pestis, Bubonic; Plague, Skin, Pneumonic Plague
A Trial to Evaluate the Safety Tolerability and Pharmacokinetics of B1344 by Subcutaneous Injection in Healthy Subjects
Recruiting
To evaluate the safety, tolerability, and immunogenicity of B1344 by single subcutaneous (s.c.) injection in healthy subjects
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
12/08/2022
Locations: California Clinical Trials Medical Group, Inc., Glendale, California
Conditions: Nonalcoholic Steatohepatitis
Study of OsrhAAT or Placebo in Healthy Volunteers
Recruiting
A Phase 1, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Single Ascending Doses of OsrhAAT in Healthy Volunteers
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
12/08/2022
Locations: Altasciences, Cypress, California
Conditions: Emphysema Secondary to Congenital AATD
Rady Children's Institute Genomic Biorepository
Recruiting
Rady Children's Institute for Genomic Medicine (RCI) will collect biological samples (such as blood), derived genomic sequences (from DNA and RNA), and clinical features in a Biorepository as a standardized resource for future research studies. The purpose of the Genomic Institute Biorepository is to provide consented samples and data for basic and clinical research related to the genomic cause and treatment of childhood disease, and, in the future, as reference (Quality Control) data to improve... Read More
Gender:
All
Ages:
All
Trial Updated:
12/08/2022
Locations: Rady Pediatric Genomics & Systems Medicine Institute, San Diego, California
Conditions: Genetic Diseases
STIMFIX Trail Lead Anchor System for Dorsal Column Stimulator Trail Leads (SECURE Study)
Recruiting
This project will investigate the efficacy of a Stimfix Trail lead anchor system (StimfixTM) in patients undergoing dorsal column stimulator trial. In dorsal column stimulator trails, two leads are placed in the epidural space and various frequencies, pulse widths, and amplitudes are run to reduce pain perception. This therapy has been in use for the last 70 years and today there are about 100,000 implants done annually for various pain indications. The process of obtaining the therapy requires... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/07/2022
Locations: Nuvation Pain Group, Los Angeles, California
Conditions: Pain
A Study to Evaluate EDP-235 in Non-hospitalized Adults With COVID-19
Recruiting
Study of EDP-235 in Non-hospitalized Adults with Mild or Moderate COVID-19.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
12/06/2022
Locations: Torrance Clinical Research Institute, Lomita, California
Conditions: COVID-19
Meditation and Education That is Nurse Delivered for Symptom Management in Paroxysmal Atrial Fibrillation (PAF)
Recruiting
The aim of this project is to determine whether the entire intervention (Mindfulness meditation, AF education, and weekly phone visits) that is nurse delivered to individuals with paroxysmal atrial fibrillation is more effective than a combination, single or no intervention in the reduction of overall AF symptoms, anxiety, and negative illness perception; or the improvement of quality of life (QOL) and functional status.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/06/2022
Locations: Stanford Health Care, Stanford, California
Conditions: Paroxysmal Atrial Fibrillation
Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure
Recruiting
This study is designed to evaluate the clinical utility of a known intraoperative neuromonitoring modality (SSEP) using saphenous nerve as the site of stimulation to identify changes to the lumbar nerves which may be at risk during the lateral lumbar interbody fusion (LLIF) procedure.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2022
Locations: Alphatec Spine Inc., Carlsbad, California
Conditions: Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity, Spinal Instability
Clinical Trial Evaluating Outcomes of Self-Fit and Professionally Fit Hearing Aids
Recruiting
Approximately 48 million people in the United States have hearing loss or hearing difficulties in noisy environments. Whisper.ai Inc has previously brought to market a commercial hearing aid system that reduces background noise and amplifies voices and sounds of interest using its proprietary platform based on machine learning and artificial intelligence technologies. Whisper.ai Inc now seeks to bring to market a new hearing system that will incorporate a "self-fitting" capability. Self-fitting... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
12/02/2022
Locations: Whisper.ai, San Francisco, California
Conditions: Hearing Loss
A Study of Concurrent Stereotactic Body Radiotherapy With Opdualag in Metastatic Uveal Melanoma
Recruiting
This is a phase 2 trial of concurrent stereotactic radiation therapy (SBRT) with immunotherapy with relatlimab and nivolumab for up to two years. SBRT will be given in three doses of 15Gy each to 1-5 separate metastases. Opdualag (nivolumab 480mg and relatlimab 160mg) will be given every 4 weeks for two years
Gender:
All
Ages:
18 years and above
Trial Updated:
12/02/2022
Locations: California Pacific Medical Center Research Institute, San Francisco, California
Conditions: Uveal Melanoma