California is currently home to 5579 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry
Recruiting
The objective of this study is to evaluate the procedural and clinical outcomes of patients with bicuspid aortic valve stenosis undergoing transcatheter aortic valve replacement.
Gender:
ALL
Ages:
Between 19 years and 129 years
Trial Updated:
02/07/2019
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Bicuspid Aortic Valve
Safety and Efficacy Study of OMS721 in Patients With Atypical Hemolytic Uremic Syndrome
Recruiting
The purpose of this study is to evaluate the platelet count change from baseline and safety of OMS721 in adults and adolescents with atypical hemolytic uremic syndrome (aHUS). The study will also evaluate pharmacokinetics (PK), pharmacodynamics (PD), and anti-drug antibody response (ADA).
Gender:
ALL
Ages:
12 years and above
Trial Updated:
10/17/2018
Locations: Omeros Investigational Site, Los Angeles, California
Conditions: Thrombotic Microangiopathies, Atypical Hemolytic Uremic Syndrome
Study of the TearCare System in Dry Eye Disease
Recruiting
This study is being conducted to evaluate the short-term (1 month) safety and effectiveness of a single TearCare procedure to treat adult patients with dry eye disease. NOTE: All sites have been selected for this study.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
08/15/2018
Locations: Eye Research Institute, Newport Beach, California
Conditions: Dry Eye
Impact of Unrestrictive Exercise Following Mid-Urethral Sling Surgery
Recruiting
To determine the impact of unrestricted postoperative activity on intermediate- and long-term continence outcomes of mid-urethral sling surgery in women with stress urinary incontinence. To assess the natural return to baseline activity level when patients are unrestricted following mid-urethral sling surgery with or without concomitant anterior or posterior pelvic organ prolapse repair.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Stress Urinary Incontinence
The Use of cineMRI to Evaluate Botox in Patients With Medication Refractory Overactive Bladder
Recruiting
With the goal of providing improved treatment to patients with overactive bladder symptoms (OAB), the investigators seek to apply the new technology of time-resolved (cine) MRI combined with urodynamics (UDS) to understand the exact effect of intravesical botulinum toxin on bladder physiology. The investigators will specifically aim to assess the physiological mechanism by which intravesical botulinum alleviates urgency and urge incontinence symptoms in women with OAB refractory to medical thera... Read More
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Overactive Bladder
Does Bladder Instillation Reduce Time to Discharge After Sling Surgery
Recruiting
The purpose of this randomized control trial study is to determine if intraoperative bladder instillation of fluid decreases the time to discharge after having an outpatient mid-urethral sling procedure, and to measure the cost savings of this decrease in hospital stay. Charges will be broken down between recovery room charges and discharge area, as recovery room charges are significantly higher. The investigators suspect that a shorter time in the recovery room will translate into fewer charges... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/17/2018
Locations: Cedars-Sinai Medical Center, Beverly Hills, California
Conditions: Stress Urinary Incontinence
Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
Recruiting
The purpose of this study is twofold. First, is to determine whether vancomycin is effective in the early treatment of Biliary Atresia (BA) and Primary Sclerosing Cholangitis (PSC), and if so, by what mechanism. Secondly, to characterize human intestinal microbial communities and their interactions with the host.
Gender:
ALL
Ages:
Between 2 weeks and 40 years
Trial Updated:
11/10/2016
Locations: Sacramento Pediatric Gastroenterology, Sacramento, California
Conditions: Primary Sclerosing Cholangitis, Biliary Atresia
Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS
Recruiting
This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and/or eating restriction accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include anxiety, emotional lability, depression, irritability, aggression, oppositionality, deterioration in school performance, behavioral... Read More
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
10/05/2016
Locations: Stanford University, Palo Alto, California
Conditions: Pediatric Acute-Onset Neuropsychiatric Syndrome, Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections, PANS, PANDAS
Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease
Recruiting
To identify demographic, clinical, genetic, immunologic and/or microbial (i.e., fecal stream characterization) risk factors that influence the likelihood of development of the HAEC phenotype in children who carry the diagnosis of HD. The newly formed HAEC Collaborative Research Group (HCRG) will utilize the 4 participating centers in the current consortia and recruit additional centers to enroll children diagnosed with Hirschsprung disease. 1a: To recruit 200 patients with Hirschsprung disease... Read More
Gender:
ALL
Ages:
Between 1 day and 17 years
Trial Updated:
08/10/2016
Locations: Cedars-Sinai Medical Center 8723 Alden Drive, Suite 240, Los Angeles, California
Conditions: Hirschsprung Disease, Enterocolitis
IRIS Registry: Intelligent Research in Sight Registry
Recruiting
The IRIS™ Registry (Intelligent Research in Sight) is the nation's first comprehensive eye disease clinical registry. The American Academy of Ophthalmology is developing it as part of the profession's shared goal of continual improvement in the delivery of eye care.The IRIS Registry will be a centralized system for ophthalmology practices to promote practice innovations and achieve clinical excellence.
Gender:
ALL
Ages:
6 months and above
Trial Updated:
07/11/2016
Locations: American Academy of Opthalmology, San Francisco, California
Conditions: Eye Diseases
Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of Recurrence
Recruiting
Most pediatric patients with solid tumors respond to initial high-dose, intensive therapy and complete treatment in remission. High-risk patients however, frequently have recurrent disease which is then treated with ad hoc regimens or early phase therapies with little benefit to the patient. Metronomic therapy (MC), defined as lower dose continuous drug exposure, has been successfully tested in pediatric leukemias with excellent results in terms of improved outcome, toxicity profiles, and cost.... Read More
Gender:
ALL
Ages:
Between 12 months and 31 years
Trial Updated:
05/13/2015
Locations: Miller Children's and Women's Hospital Long Beach, Long Beach, California
Conditions: Solid Tumor