California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Dupilumab in the Treatment of Pediatric Alopecia Areata
Recruiting
This is a prospective, randomized, double-blind, placebo-controlled clinical trial. The study will take place at four sites. This trial will enroll a total of 76 children and adolescents with moderate to severe AA (affecting at least 30% of the scalp) at the time of screening with a targeted 61 participants completing through Week 48. All subjects must have evidence of hair regrowth within the last 7 years of their last episode of hair loss; and have screening IgE ≥200 and/or have personal and/o... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
02/06/2025
Locations: University of California, Irvine, Irvine, California
Conditions: Alopecia Areata
The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency
Recruiting
The primary purpose of Study INZ701-104 (the ENERGY study) is to assess the safety and tolerability of INZ-701 in infants with ENPP1 Deficiency or with ABCC6 Deficiency.
Gender:
ALL
Ages:
1 year and below
Trial Updated:
02/06/2025
Locations: Rady Children's Hospital, San Diego, California
Conditions: Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Autosomal Recessive Hypophosphatemic Rickets, Generalized Arterial Calcification of Infancy, ATP-Binding Cassette Subfamily C Member 6 Deficiency, Pseudoxanthoma Elasticum
Project Dulce for Arab Americans With Type 2 Diabetes
Recruiting
Arab Americans (AA) face many challenges in diabetes self-management due to the limited educational resources and support available for them. The cultural and linguistic barriers between patients and health care providers lead to poor diabetes management and outcomes. This study (Project Dulce Arabic) is adapted from the Project Dulce, an American Diabetes Association (ADA)-recognized Diabetes Self-Management Education Support (DSMES) program. Project Dulce Arabic comprises both peer-led diabete... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: San Ysidro Health, El Cajon, California
Conditions: Diabetes Mellitus, Type 2
Reduced-dose Botox for Urgency Incontinence Among Elder Females
Recruiting
The purpose of this study is to study the treatment of urgency urinary incontinence (UUI), specifically among women 70 years and older, by comparing reduced versus standard dose of onabotulinumtoxinA (BTX; trade name BOTOX(c)) injection in the bladder.
Gender:
FEMALE
Ages:
70 years and above
Trial Updated:
02/06/2025
Locations: Kaiser Permanente Medical Group, San Diego, California
Conditions: Overactive Bladder, Urinary Incontinence in Old Age, Urgency Urinary Incontinence
A Prospective and Retrospective Observational Study of Multidrug-Resistant Patient Outcomes With and Without Ibalizumab
Recruiting
The virological efficacy of ibalizumab has been clearly demonstrated in multiple clinical trials. This study will expand ibalizumab's clinical data set and allow a better understanding of the virologic response durability on ARV regimens with or without ibalizumab in a heterogeneous real-world patient population. Additional data on the efficacy and safety of ibalizumab and its impact on patient reported outcomes will be captured until study end. Primary Objective: To evaluate the long-term eff... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: Ruane Clinical Research, Los Angeles, California
Conditions: HIV Infections, Multi-Antiviral Resistance
A Clinical Study to Assess the Efficacy and Safety of Alpha DaRT224 for the Treatment of Patients With Recurrent Cutaneous Squamous Cell Carcinoma
Recruiting
This is a multi-center clinical study enrolling up to 86 participants. The primary objectives are to determine the objective response rate (ORR) established by the confirmed best overall response (BOR) following intratumoral administration of DaRT - Diffusing Alpha-Emitters Radiation Therapy, as well as to assess the Duration of Response (DOR) 6 months from initial response. Secondary objectives are to assess the safety of DaRT, and to assess the progression free survival (PFS), overall survival... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: UCLA, Los Angeles, California
Conditions: Recurrent Squamous Cell Carcinoma
EyeConic: Qualification for Cone-Optogenetics
Recruiting
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Gender:
ALL
Ages:
All
Trial Updated:
02/06/2025
Locations: University of California San Francisco, Department of Ophthalmology, San Francisco, California
Conditions: Retinal Dystrophies
An Optimal Dose Finding Study of N-Acetylcysteine in Patients with Myeloproliferative Neoplasms
Recruiting
This is a phase I/II study evaluating the optimal dose of N-acetylcysteine (N-AC) in patients with myeloproliferative neoplasms (MPN).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: University of California, Irvine, Irvine, California
Conditions: Myeloproliferative Neoplasm, MPN, Essential Thrombocythemia, Polycythemia Vera, Myelofibrosis
Strengths-based Linkage to Alcohol Care (SLAC) for Hazardous Drinkers in Primary Care
Recruiting
This pilot study will determine the feasibility, acceptability, and efficacy of Strengths-based Linkage to Alcohol Care (SLAC; a behavioral intervention) to link Veterans, identified as hazardous drinkers in VHA primary care, to alcohol care. Participants screening positive in VA primary care for hazardous drinking and posttraumatic stress disorders (PTSD) and/or depression in the past year will be recruited. Participants will be randomly assigned to one of two study conditions - SLAC plus usual... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California
Conditions: Alcohol-induced Disorders, Alcohol Drinking, Mental Health
GDNF Gene Therapy for Multiple System Atrophy
Recruiting
The objective of this randomized, double-blinded, placebo-controlled Phase 1 investigation is to evaluate the safety and potential clinical effect of AAV2-GDNF delivered to the putamen in subjects with either a possible or probable diagnosis of Multiple System Atrophy.
Gender:
ALL
Ages:
Between 35 years and 75 years
Trial Updated:
02/06/2025
Locations: University of California Irvine, Irvine, California
Conditions: Multiple System Atrophy
Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17
Recruiting
This is a phase II study using risk and response-adapted therapy for low, intermediate and high risk classical Hodgkin lymphoma. Chemotherapy regimens will be based on risk group assignment. Low-risk and intermediate- risk patients will be treated with bendamustine, etoposide, Adriamycin® (doxorubicin), bleomycin, Oncovin® (vincristine), vinblastine, and prednisone (BEABOVP) chemotherapy. High-risk patients will receive Adcetris® (brentuximab vedotin), etoposide, prednisone and Adriamycin® (doxo... Read More
Gender:
ALL
Ages:
25 years and below
Trial Updated:
02/06/2025
Locations: Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Conditions: Hodgkin Lymphoma
Two Dose Levels of Privigen in Pediatric CIDP
Recruiting
A randomized, open-label, prospective, multicenter study designed to investigate 2 dose levels in pediatric subjects 2 to ≤ 17 years of age with confirmed or possible CIDP, either previously exposed to IVIG treatment or unexposed to IVIG treatment
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
02/06/2025
Locations: Children's Hospital of Los Angeles, Los Angeles, California
Conditions: Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)