California is currently home to 5590 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MDMA-Assisted Therapy for Veterans with Moderate to Severe Post Traumatic Stress Disorder
Recruiting
This randomized, double-blind, single-site phase II 2-arm study will investigate the safety and preliminary efficacy of MDMA-assisted therapy compared with low dose d-amphetamine-assisted therapy on the severity of PTSD symptoms in participants aged 18 years and older with PTSD of at least moderate severity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: VA Greater Los Angeles Healthcare System, Westwood campus, Los Angeles, California
Conditions: Post Traumatic Stress Disorder
Study of VGA039 in Healthy Volunteers and Patients with Von Willebrand Disease (VIVID)
Recruiting
The VIVID study is structured in a master protocol format comprised of multiple parts that evaluate intravenous (IV) and subcutaneous (SC) VGA039 in healthy volunteers and subjects with von Willebrand Disease (VWD) and other bleeding disorders.
Gender:
ALL
Ages:
Between 12 years and 60 years
Trial Updated:
03/24/2025
Locations: Orthopedic Institute for Children (UCLA), Los Angeles, California
Conditions: Von Willebrand Diseases
Standardized Extract of Cultured Lentinula Edodes Mycelia (AHCC®) in Ovarian Cancer Patients on Adjuvant Chemotherapy
Recruiting
This is a pilot phase, randomized, double-blinded feasibility pilot study of AHCC in participants with ovarian cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: University of California Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Ovarian Epithelial Carcinoma, Fallopian Tube Carcinoma, Peritoneal Carcinoma
Therapies for Down Syndrome Regression Disorder
Recruiting
Individuals with Down syndrome (DS) have an increased risk of numerous co-occurring conditions, including the neuropsychiatric condition known as Down Syndrome Regression Disorder (DSRD). A DSRD diagnosis often includes a sub-acute onset of catatonia, mutism, depersonalization, loss of ability to perform activities of daily living, hallucinations, delusions, and aggression and is most commonly observed in adolescents and young adults. The study evaluates the safety and efficacy of three current... Read More
Gender:
ALL
Ages:
Between 8 years and 30 years
Trial Updated:
03/24/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Down Syndrome, Regression
A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma
Recruiting
The primary objectives of Cohort A Phase 1b are to evaluate the safety and tolerability of TTI-101 orally administered as a single agent to participants with locally advanced or metastatic, and unresectable Hepatocellular Carcinoma (HCC) and to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of TTI-101 as a single agent. The primary objectives of Cohort A Phase 2 are to evaluate the safety and tolerability of TTI-101 orally administered as a single agent at the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: University of California San Diego, La Jolla, California
Conditions: Hepatocellular Carcinoma
Virtual Care Strategies to Improve Participation in Cardiac Rehabilitation Among Veterans
Recruiting
Home-based CR (HBCR) is an alternative to traditional CR programs that has comparable efficacy in improving morbidity/mortality and increases access to critical services. There is major potential to improve Veteran engagement in CR by combining digital coaching (d-Coaching) with existing VA-supported technologies. The investigator's theory-based intervention targets a critical component of successful CR engagement that is not available through traditional programs: virtual social support through... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/24/2025
Locations: San Francisco VA Medical Center, San Francisco, CA, San Francisco, California
Conditions: Cardiovascular Diseases
Trial of Indication-Based Transfusion of Red Blood Cells in ECMO
Recruiting
TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, is a multicenter, prospective, randomized clinical trial. The overarching goal of TITRE is to determine whether restricting red blood cell (RBC) transfusion according to an indication-based strategy for those with bleeding and/or deficit of tissue oxygen delivery, compared with transfusion based on center-specific hemoglobin or hematocrit thresholds, can reduce organ dysfunction and improve later neurodevelopment in critic... Read More
Gender:
ALL
Ages:
Between 0 days and 6 years
Trial Updated:
03/24/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion, Organ Failure, Multiple
Study of INCB123667 in Subjects With Advanced Solid Tumors
Recruiting
This is an open-label, dose-escalation and dose-expansion study to determine the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy of INCB123667 when administered as monotherapy and in combination with anticancer therapies in participants with selected advanced or metastatic solid tumors. This study will consist of 2 parts. In Part 1, INCB123667 will be administered as monotherapy and in Part 2, INCB123667 will be administered in combination with anticancer therapies of intere... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Solid Tumors
Families, Responsibility, Education, Support, and Health for Executive Function
Recruiting
The pilot study will be a one group open-label treatment program and will be used to refine a parent-based behavioral treatment enhanced with executive-function training (PBT-EF) for children with comorbid overweight or obesity and Attention-Deficit Hyperactivity Disorder (ADHD).
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
03/24/2025
Locations: UCSD Center for Healthy Eating and Activity Research (CHEAR), San Diego, California
Conditions: Overweight and Obesity, Attention-Deficit Hyperactivity Disorder
Incentive Processing and Learning in Anorexia Nervosa and Bulimia Nervosa
Recruiting
The purpose of this study is to investigate areas of the brain responsible for 'liking', 'wanting', and learning in adults with eating disorders using brain imaging techniques, computer tasks, a test meal, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 252 women with an eating disorder (63 AN-restricting type (AN-R), 63 AN-binge eating/purging type... Read More
Gender:
FEMALE
Ages:
Between 18 years and 39 years
Trial Updated:
03/24/2025
Locations: UCSD Eating Disorders Treatment and Research Program, La Jolla, California
Conditions: Anorexia Nervosa, Bulimia Nervosa
Parenting Stress mHealth
Recruiting
Parenting stress is a well-documented barrier to youth engagement in community-based substance use treatment. The current project aims to develop and evaluate a mobile health parenting stress intervention for caregivers of justice-involved youth, a population with high rates of substance use and low rates of treatment engagement.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
03/24/2025
Locations: UCSF Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Stress
A Study of Intravesical Enfortumab Vedotin For Treatment of Patients With Non-muscle Invasive Bladder Cancer (NMIBC)
Recruiting
This study will test a drug called enfortumab vedotin in participants with a type of bladder cancer called non-muscle invasive bladder cancer (NMIBC). This study will also evaluate what the side effects are and if the drug works to treat NMIBC. A side effect is anything a drug does to your body besides treating your disease. In this study enfortumab vedotin will be put into the bladder using a catheter. A catheter is a thin tube that can be put into your bladder.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: UCLA Department of Medicine - Hematology & Oncology, Los Angeles, California
Conditions: Urinary Bladder Neoplasms, Carcinoma in Situ, Carcinoma Transitional Cell, Non-muscle Invasive Bladder Cancer, NMIBC