California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
BHV-7000 Acute Treatment of Bipolar Mania
Recruiting
The purpose of this study is to determine whether BHV-7000 is a safe and effective acute treatment for manic episodes in bipolar disorder I.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
06/18/2024
Locations: Advanced Research Center, Inc., Anaheim, California
Conditions: Bipolar Disorder
Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine
Recruiting
A migraine is a moderate to severe headache typically on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms. Menstrual migraine (MM) is defined as migraine attacks that occur within the perimenstrual period (PMP) in at least 2 out of 3 menstrual cycles. The PMP is from 2 days before the onset of menstrual bleeding to 2 days after. This study will assess how safe and effective ubrogepant i... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: Neuro Pain Medical Center /ID# 257155, Fresno, California
Conditions: Migraine
Clareon PanOptix Pro vs. Clareon PanOptix - Study B
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of Clareon™ PanOptix™ Pro Trifocal Intraocular Lens (IOL) compared to Clareon™ PanOptix™ Trifocal IOL.
Gender:
All
Ages:
22 years and above
Trial Updated:
06/18/2024
Locations: Wolstan & Goldberg Eye Associates, Torrance, California
Conditions: Aphakia, Presbyopia
Clareon PanOptix Pro vs. Clareon PanOptix - Study A
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of Clareon™ PanOptix™ Pro Trifocal Intraocular Lens (IOL) compared to Clareon™ PanOptix™ Trifocal IOL.
Gender:
All
Ages:
22 years and above
Trial Updated:
06/18/2024
Locations: Wolstan & Goldberg Eye Associates, Torrance, California
Conditions: Aphakia, Presbyopia
Feasibility of a Prenatal Yoga Mobile App in African American Pregnant Women
Recruiting
The goal of this research is to test if a prenatal yoga app can improve well-being in African American/Black (AA) pregnant women. The main questions it aims to answer are: Is the Down Dog prenatal yoga app feasible for AA pregnant women? How does mental and physical health change after using the Down Dog app for 12-weeks? What cultural adaptations to the Down Dog app are needed? The study lasts for 12 weeks and participants are asked to: do prenatal yoga with the app for at least 20 min/day,... Read More
Gender:
Female
Ages:
Between 18 years and 46 years
Trial Updated:
06/18/2024
Locations: San Diego State University, San Diego, California
Conditions: Pregnancy Related, Mental Health Issue, Discrimination, Racial, Stress, Depression
A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
Recruiting
This study will evaluate the efficacy and safety of Armour Thyroid treatment compared with synthetic T4 in subjects who have primary hypothyroidism and are currently stabilized (i.e., in-range thyroid-stimulating hormone [TSH]) on synthetic T4 treatment. This study will also therefore evaluate the efficacy and safety of dose conversion from synthetic T4 therapy to Armour Thyroid therapy.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
06/18/2024
Locations: John Muir Medical Center /ID# 257103, Concord, California
Conditions: Hypothyroidism
Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With Biktarvy
Recruiting
The goal of this clinical study is to learn more about the effects of switching to the study drugs, bictegravir (BIC)/lenacapavir (LEN), fixed-dose combination (FDC) versus current therapy bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) FDC in people living with HIV-1 (PWH). The primary objective of this study is to learn how effective it is to switch to BIC/LEN FDC tablets versus continuing on B/F/TAF FDC tablets in virologically suppressed PWH.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: Be Well Medical Center, Berkeley, California
Conditions: HIV-1-infection
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer
Recruiting
The main purpose of this study is to compare the disease-free survival between participants receiving treatment with TAR-210 versus investigator's choice of intravesical chemotherapy for treatment of intermediate-risk NMIBC.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: Genesis Research LLC, Los Alamitos, California
Conditions: Non-Muscle Invasive Bladder Cancer
CMV-specific HIV-CAR T Cells as Immunotherapy for HIV/AIDS
Recruiting
Human immunodeficiency virus type 1 (HIV-1) causes a persistent infection that ultimately leads to acquired immunodeficiency syndrome (AIDS). Treatment of HIV-1 infection with combination anti-retroviral therapy (ART) suppresses HIV-1 replication to undetectable viral levels and saves lives. Nevertheless, ART cannot eradicate latent cellular reservoirs of the virus, and HIV-1 infection remains a life-long battle. Adoptive cellular immunotherapy using chimeric antigen receptor (CAR) engineered T... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: HIV-1
SW-682 in Advanced Solid Tumors
Recruiting
This is a first-in-human (FIH), Phase 1a/1b open-label, multicenter, dose escalation and dose expansion study of SW-682 in adult participants with metastatic or unresectable advanced solid tumors with or without Hippo pathway alterations that are refractory to, or have progressed, during or after appropriate prior systemic anticancer therapy, including chemotherapy, immunotherapy, radiation therapy or targeted therapy, or for which no treatment is available, or prior standard of care (SOC) thera... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: SpringWorks Clinical Trial Site, La Jolla, California
Conditions: Advanced Solid Tumor, Mesothelioma, Malignant
A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor
Recruiting
This is a parallel group, Phase 3, multinational, multicenter, randomized, double-blind, placebo-controlled, 3-arm study for treatment of participants diagnosed with moderate-to-severe AD on background TCS who have had inadequate response to prior biologic or oral JAKi therapy. The purpose of this study is to measure the efficacy and safety of treatment with amlitelimab solution for subcutaneous (SC) injection compared with placebo in participants with moderate-to-severe AD aged 12 years and ol... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
06/18/2024
Locations: Encino Research Center Site Number : 8401042, Encino, California
Conditions: Dermatitis Atopic
A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis on Background Topical Corticosteroids
Recruiting
This is a parallel group, Phase 3, multinational, multicenter, randomized, double-blind, placebo controlled, 3-arm study for treatment of participants diagnosed with moderate-to-severe atopic dermatitis (AD) with a history of inadequate response of topical treatment, on background topical corticosteroid (TCS) and/or topical calcineurin inhibitor (TCI). The purpose of this study is to measure the efficacy and safety of treatment with amlitelimab solution for subcutaneous (SC) injection compared... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
06/18/2024
Locations: Encino Research Center Site Number : 8401042, Encino, California
Conditions: Dermatitis Atopic