California is currently home to 5591 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma
Recruiting
This is a Phase 2 study using talimogene laherparepvec, nivolumab, and trabectedin as first, second or third line therapy for advanced sarcoma, including desmoid tumor and chordoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2025
Locations: Sarcoma Oncology Center, Santa Monica, California
Conditions: Sarcoma
SAINT:Trabectedin, Ipilimumab and Nivolumab for Previously Treated Advanced Soft Tissue Sarcoma
Recruiting
This is an open label, dose-seeking phase 1/2 study using escalating doses of TRABECTEDIN given intravenously with defined doses of IPILIMUMAB and NIVOLUMAB based on preliminary results of the Checkmate 012 trial for NSCLC (Hellman et al., 2016). For the Phase 1 Part of Study, only previously treated patients will be enrolled. For the Phase 2 Part of Study, previously treated patients will be enrolled.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2025
Locations: Sarcoma Oncology Research Center, Santa Monica, California
Conditions: Advanced Soft Tissue Sarcoma, Metastatic Soft Tissue Sarcoma
Therapeutic Effects of Electrical Vestibular Stimulation (EVS) on Balance and Gait
Recruiting
The aim of the study to is determine the safety, feasibility, efficacy, and persistence of non-invasive EVS to improve balance and gait performance in healthy individuals across the lifespan. Specifically, our objective is to measure balance and gait performance before, during and after exposure to single sessions and across repeated sequences of EVS at multiple study partner sites.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/20/2025
Locations: Caring Hands Caregivers, Cupertino, California
Conditions: Vestibulopathy
Spermatogonial Differentiation Via Testicular Organoid
Recruiting
Purpose: This clinical trial aims to explore the potential for human sperm production in vitro by sustaining a laboratory-cultured adult testicular environment. It also seeks to identify genetic factors contributing to human sterility and failed spermatogenesis. The study's primary objectives include: 1. Identifying genomic markers associated with sterility and failed spermatogenesis. 2. Developing an ex vivo (outside the body) testis "organ-on-a-chip" ("iTestis") to support stem cell cultivat... Read More
Gender:
MALE
Ages:
Between 18 years and 60 years
Trial Updated:
02/20/2025
Locations: The Turek Clinic, San Francisco, California
Conditions: Infertility, Male, Gene Abnormality, Sterility, Male
VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease
Recruiting
Transmural healing (TMH) is recognized as a potentially important measure of Crohn's disease (CD) activity but not a formal target. Observational studies suggest that TMH may be associated with better long-term outcomes. The study will evaluate TMH using noninvasive intestinal ultrasound (IUS), a patient-friendly technique that can be performed routinely in clinical practice. The aim of the study is to determine if treating to a target of corticosteroid-free (CS-free) IUS outcomes + clinical sym... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/20/2025
Locations: TLC Clinical Research Inc - Los Angeles, Los Angeles, California
Conditions: Moderately to Severely Active Crohn's Disease, Crohn Disease, Disease Crohn
Smoke-free Home Study in Subsidized Housing
Recruiting
Comprehensive smoke-free policies have the potential to substantially reduce tobacco-related disparities among populations in subsidized housing. This study fills this gap by identifying approaches to increase the implementation of smoke-free policies in all types of subsidized housing by increasing the voluntary adoption of smoke-free homes and promoting access to smoking cessation services.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/20/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Tobacco Dependence, Tobacco Smoking
Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology
Recruiting
This is a single-center study of 80 subjects with asthma including those with obesity and metabolic dysfunction (MD), those with obesity and without metabolic dysfunction, those with severe asthma and mucus plugging and those with severe asthma and without mucus plugging. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in a cardiopulmonary exercise testing (CPET) visit to compare lung function markers and change... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/20/2025
Locations: UCSF Airway Clinical Research Center, San Francisco, California
Conditions: Asthma
ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
Recruiting
The goal of this Phase 3 clinical trial is study the safety and efficacy of the nextgen anti-CTLA-4 antibody, gotistobart (ONC-392/BNT316), in patients with metastatic non-small cell lung cancer who have disease progressed on anti-PD-1/PD-L1 antibody based therapy. The study will test whether gotistobart, in comparison with chemotherapy agent docetaxel, could prolong the life for NSCLC patients. Patients will be randomized to be treated with either gotistobart or docetaxel, IV infusion, once eve... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/20/2025
Locations: The Oncology Institute (TOI) Clinical Research - 1109, Cerritos, California
Conditions: Non Small Cell Lung Cancer
Translational Research Center in Lung Cancer Disparities (TRACER) Project 2
Recruiting
The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.
Gender:
MALE
Ages:
Between 18 years and 75 years
Trial Updated:
02/20/2025
Locations: University of Southern California, Los Angeles, California
Conditions: Smoking, Smoking Behaviors, Smoking Cessation, Stress Reaction
Minnelide and Osimertinib for the Treatment of Advanced EGFR Mutated Non-Small Cell Lung Cancer
Recruiting
This phase Ib trial tests the side effects and best dose of minnelide when given together with osimertinib for the treatment of non-small cell lung cancer that has spread to other places in the body (advanced) and has a change (mutation) in a gene called EGFR. Minnelide is a biologically inactive compound that can be broken down in the body to produce a drug that rapidly releases the active compound triptolide when exposed to phosphatases in the bloodstream. Sometimes, mutations in the EGFR gene... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/20/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Advanced Lung Non-Small Cell Carcinoma, Locally Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8, Unresectable Lung Non-Small Cell Carcinoma
A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer
Recruiting
Men with localized, intermediate risk prostate cancer will be randomized to undergo either radical prostatectomy or the TULSA procedure, with a follow-up of 10 years in this multi-centered randomized control trial. This study will determine whether the TULSA procedure is as effective and more safe compared to radical prostatectomy.
Gender:
MALE
Ages:
Between 40 years and 80 years
Trial Updated:
02/20/2025
Locations: Genesis Healthcare, Downey, California
Conditions: Prostate Cancer, Prostate Adenocarcinoma
HM15136 (efpegerglucagon) Treatment for 8 Weeks in Subjects Aged ≥2 Years with Congenital Hyperinsulinism (CHI)
Recruiting
This study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of HM15136 when used as add-on therapy in subjects with CHI with persistent hypoglycemia while on standard of care treatment (SoC). HM15136 will be administered once weekly in multiple doses to subjects in multiple age including pediatric to find appropriate exposure-response data.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
02/20/2025
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Congenital Hyperinsulinism