California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
Recruiting
The primary purpose of this study is to evaluate the efficacy of ION363 on clinical function and survival in carriers of fused in sarcoma mutations with amyotrophic lateral sclerosis (FUS-ALS).
Gender:
ALL
Ages:
10 years and above
Trial Updated:
11/08/2024
Locations: University of California San Diego, La Jolla, California
Conditions: Amyotrophic Lateral Sclerosis
Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study
Recruiting
Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with heart failure and reduced ejection fraction (HFrEF).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: University of California San Diego, La Jolla, California
Conditions: Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
A Nutritional Intervention for Body, Brain, and Longevity Effects (NIBBLE)
Recruiting
The study aims to evaluate the safety, feasibility, and efficacy of six-month fasting-mimicking (FMD) intervention in middle-aged adults at elevated risk for Alzheimer's disease due to the apolipoprotein (APOE) ε4 allele. Participants randomly assigned to the active intervention will consume a FMD for 5-days each month over a period of 6-months.
Gender:
ALL
Ages:
Between 45 years and 65 years
Trial Updated:
11/07/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Cerebral Blood Flow, APOE 4
Role of Race in Nutritional Approach in Men on ADT
Recruiting
There is a well-documented association between androgen deprivation therapy (ADT) and cardiovascular morbidity. A majority of men on ADT gain weight contributing to an increase in cardiovascular risk factors (CVRFs) and cardiovascular morbidity. Dietary intervention combined with exercise have shown success in reducing weight/fat mass and improving cardiovascular risk factors (CVRF). There is little data on whether African American men would respond to diet and exercise interventions differently... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: Greater Los Angeles Division of Veterans Affairs, Los Angeles, California
Conditions: Prostate Cancer Metastatic Disease
A Study to Investigate the Efficacy and Safety of NSI-8226 in Adults with Eosinophilic Esophagitis
Recruiting
Phase 2 study to evaluate the safety, tolerability, PK, immunogenicity, and pharmacodynamics of solrikitug in adult participants with eosinophilic esophagitis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/07/2024
Locations: Research Site 1015, San Diego, California
Conditions: Eosinophilic Esophagitis (EoE)
Psilocybin Therapy for Depression in Parkinson's Disease
Recruiting
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/07/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Parkinson Disease, Depression
Starting Technology in At Risk Type 1 Diabetes Study
Recruiting
Diabetes technology has revolutionized T1D management, disparities in technology access are evident among racial-ethnic minorities, patients with lower socioeconomic status and those with poorly controlled T1D (A1c\>8.5%). In order to examine whether diabetes technology can reduce diabetes care burdens and enhance outcomes among some of highest need patients, diabetes technology clinical trials must be expanded beyond the very select populations included in studies thus far (ie., mostly White, h... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: UCLA, Santa Monica, California
Conditions: Diabetes Mellitus, Type 1
A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia
Recruiting
This clinical trial will test the safety and efficacy of combining trametinib and azacitidine in patients with juvenile myelomonocytic leukemia (JMML). Newly diagnosed lower-risk JMML patients will receive trametinib and azacitidine. High-risk JMML patients will receive trametinib, azacitidine, fludarabine, and cytarabine.
Gender:
ALL
Ages:
Between 1 month and 21 years
Trial Updated:
11/07/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Leukemia, Juvenile Myelomonocytic, JMML, JCML, Neurofibromatosis 1, CBL Syndrome
A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis
Recruiting
The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years up to \< 18 years of age). Participants who will complete the total 52-week treatment period will have the opportunity to continue in a Long-Term Extension (LTE) Period of up to 4 years (5 years after study enrollment), or until marketing authorization is obtained in the participant's country, which... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
11/07/2024
Locations: Valley View Wellness Medical Center, Garden Grove, California
Conditions: Ulcerative Colitis
Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms
Recruiting
The main purpose of this study is to determine the effectiveness of the study drug pacritinib in people with relapsed or refractory lymphoproliferative disorders.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: City of Hope, Duarte, California
Conditions: T-Cell Neoplasm, Lymphoproliferative Disorders
Use of CGM in Kidney Transplant Recipients
Recruiting
The investigators want to study the impact CGM (continuous glucose monitoring) has on patients glycemic control as determined by time in range (TIR 70-180 mg/dL) in the Diabetic Kidney Transplant population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/07/2024
Locations: UC Davis Health, Sacramento, California
Conditions: Kidney Transplant; Complications, Diabetes Mellitus, Type 2, Insulin Dependent Diabetes
Development of a Research Infrastructure for Understanding and Addressing Multiple Myeloma Disparities
Recruiting
The objectives of the proposed study are to develop and evaluate protocols for ethnic/racial minority-specific research using cancer registry data. In conjunction with the Cancer Registry of Greater California (CRGC), the investigators have developed procedures to identify, recruit, and survey ethnic/racial minority patients with MM. To pilot the study, the investigators aim initially to test the feasibility of this protocol by contacting 400 eligible patients (100 African Americans, 100 Latinos... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/07/2024
Locations: University of California Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Multiple Myeloma