California is currently home to 5581 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
NCT05833217
Recruiting
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC). This study looks at whether adipose (fat) tissue contributes to PASC by driving chronic inflammation or by serving as a reservoir for SARS-CoV-2 persistence. The results will not only determine whether obesity and IR are risk factors for PASC, but will also define fundamental biology that sets the stage for the investigation of... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/02/2024
Locations: Clinical and Translational Research Unit, Palo Alto, California
Conditions: Long COVID, Insulin Resistance, Insulin Sensitivity
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Short, Simple, Exercise to Improve Circadian Dependent Postprandial Glycemic Responses
NCT05783752
Recruiting
The goal of this clinical trial is to test whether one minute of stair stepping at a comfortable pace can reduce blood sugar after meals. The main objectives of the study are: Compare continuously measured post-meal glucose after stair-stepping to control condition Compare continuously measured post-meal glucose after stair-stepping between meals Assess interaction between condition and meal to determine if the effect of stair-stepping on post-meal glucose depends on meal Participants will be... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/02/2024
Locations: San Diego State University, San Diego, California
Conditions: Postprandial Glycemic Response, Postprandial Hyperglycemia, Postprandial Insulin
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Electrical Stimulation for the Treatment of Glaucoma
NCT05626491
Recruiting
The overall aim of this study is to see whether long-term electrical stimulation with a home-stimulation device works well and is safe for the treatment of open-angle glaucoma. Open-Angle Glaucoma is a disease where the nerves in the back of your eye die off faster than expected regardless of your eye pressure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Byers Eye Institute, Palo Alto, California
Conditions: Glaucoma, Glaucoma, Open-Angle
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Electrical Stimulation for the Treatment of Optic Neuropathies
NCT05626426
Recruiting
The overall aim of this study is to see whether long-term electrical stimulation with a home-stimulation device works well and is safe for the treatment of open-angle glaucoma. Open-Angle Glaucoma is a disease where the nerves in the back of your eye die off faster than expected regardless of your eye pressure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Byers Eye Institute, Palo Alto, California
Conditions: Glaucoma, Glaucoma, Open-Angle, Optic Nerve Diseases
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Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
NCT05611242
Recruiting
The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circulation and have a proximal carotid occlusive disease (occlusion or severe stenosis).
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
12/02/2024
Locations: Pomona Valley, Pomona, California
Conditions: Acute Ischemic Stroke
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Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma
NCT05489887
Recruiting
This is a prospective, multicenter clinical trial in subjects with newly diagnosed high-risk neuroblastoma to evaluate the efficacy and safety of administering naxitamab with standard induction therapy. The initial chemotherapy will include 5 cycles of multi-agent chemotherapy. Naxitamab will be added to all 5 Induction cycles. We hypothesize that the addition of anti-GD2 therapy to induction chemotherapy will result in improved end of induction responses and improved survival.
Gender:
ALL
Ages:
Between 12 months and 21 years
Trial Updated:
12/02/2024
Locations: UCSF Benioff Children's Hospital Oakland-, Oakland, California
Conditions: High-risk Neuroblastoma
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Vincristine Pharmacokinetics in Infants
NCT05359237
Recruiting
This pilot trial compares drug exposure levels using a new method for dosing vincristine in infants and young children compared to the standard dosing method based on body surface area (BSA) in older children. Vincristine is an anticancer drug used to a variety of childhood cancers. The doses anticancer drugs in children must be adjusted based on the size of the child because children vary significantly in size (height, weight, and BSA) and ability to metabolize drugs from infancy to adolescence... Read More
Gender:
ALL
Ages:
12 years and below
Trial Updated:
12/02/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Register for Updates
Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708
NCT05317637
Recruiting
Osteogenesis imperfecta (OI) is a group of congenital and heritable bone disorders that currently affects at least 50,000 people in the United States. OI varies in severity from perinatally lethal to mild forms. The majority of cases is caused by a dominant mutation in type I collagen genes (COL1α1 and COL1α2), altering the quantity or quality of type I collagen. Although OI is typically characterized as a disease of the bone, it is perhaps more accurately described as a connective tissue disor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Osteogenesis Imperfecta
Register for Updates
The Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Cell Transplantation (The RV-BOS Study)
NCT05250037
Recruiting
This observational trial studies whether respiratory viruses are the cause of lung disease (bronchiolitis obliterans syndrome \[BOS\] or graft-versus-host disease of the lung) and changes in lung function in patients who have received a donor stem cell transplant. Patients with chronic graft-versus-host disease (cGVHD) are at higher risk of developing BOS. Studies have also shown that patients who had a respiratory viral illness early after their transplant are at higher risk of developing lung... Read More
Gender:
ALL
Ages:
8 years and above
Trial Updated:
12/02/2024
Locations: Stanford Cancer Institute, Palo Alto, California
Conditions: Bronchiolitis Obliterans Syndrome, Hematopoietic and Lymphoid Cell Neoplasm
Register for Updates
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
NCT05165706
Recruiting
This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR). Blood, adipose and stool are sampled at three timepoints; baseline, peak weight (4 weeks) and post weight loss to monitor changes in cellular processes. Additionally, direct insulin sensitivity testing, and radiological measurement of visceral fat and intrahepatic fat content is measured at three timepoints to correlate clin... Read More
Gender:
ALL
Ages:
Between 35 years and 65 years
Trial Updated:
12/02/2024
Locations: Stanford University, Stanford, California
Conditions: Diabetes Mellitus, Type 2, PreDiabetes, Insulin Resistance, Obesity, Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver, Diet Modification
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Clear Aligners for the Treatment of Dental Malocclusion in OI
NCT04815564
Recruiting
Misalignment of teeth and jaws (also called malocclusion) is a common life altering problem facing many individuals with Osteogenesis Imperfecta (OI). The presence of Dentinogenesis Imperfecta in teeth of OI individuals makes the use of conventional orthodontics in the form of braces very challenging. Clear aligners are newer form of orthodontic treatment and is less invasive than braces. Therefore, the aim of our study is to evaluate the efficiency and safety of using Invisalign clear aligners... Read More
Gender:
ALL
Ages:
Between 12 years and 40 years
Trial Updated:
12/02/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Osteogenesis Imperfecta
Register for Updates
Role of Nutrient Transit in Hyperinsulinemic Hypoglycemia
NCT04615546
Recruiting
Severe hypoglycemia (low blood sugar)after gastric bypass surgery is an increasingly recognized condition, characterized by symptoms of hypoglycemia after eating and inappropriately elevated insulin concentrations that occur at the time of hypoglycemia. Severe hypoglycemia can be dangerous and debilitating and can also impact cognitive function. At the moment no medical therapies have been developed for this disorder. Determining why some but not other patients develop this condition would allow... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Post-Bariatric Hypoglycemia
Register for Updates