California is currently home to 5591 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Rehabilitation in Safety-net Environments (RISE) to Improve Outcomes in Vulnerable Patients With COPD
Recruiting
Chronic obstructive pulmonary disease (COPD), one of the leading causes of death in the US, disproportionately affects low socioeconomic communities. While few interventions effectively modify the course of COPD and improve outcomes, pulmonary rehabilitation is the one notable exception. However, implementation of this resource-intensive program in real-life settings, and in particular, for underserved communities, has proven to be challenging. Safety-net centers that serve primarily under-insur... Read More
Gender:
ALL
Ages:
Between 40 years and 90 years
Trial Updated:
11/14/2024
Locations: Zuckerberg San Francisco General (ZSFG) Hospital, San Francisco, California
Conditions: COPD (Chronic Obstructive Pulmonary Disease)
Comparing Perclose to Statseal in Conjunction with Perclose in Femoral 6 French Arteriotomy Closure
Recruiting
The purpose of this clinical study is to compare how well two different devices for achieving hemostasis perform in patients undergoing transfemoral procedures with 6 French Access. Both devices are approved by the FDA for this use, and have already been used by clinicians on patients undergoing transfemoral procedures. It is believed that the use of both devices in combination compared to the Perclose alone will shorten the time that it takes to 'seal' the artery, resulting in a shorter period... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: UCLA Ronald Reagen, Los Angeles, California
Conditions: Arterial Occlusion, Cardiovascular Diseases, Atherosclerosis, Hematoma
Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
Recruiting
This is a multiple site, randomized, double blinded parallel-group controlled study. The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions with the STARSTIM device, which delivers transcranial cathodal direct current stimulation (tDCS). Subjects will be treated with STARTSTIM or sham device for 10 sessions over a 2-week period. The subjects will be followed for an additional 10 weeks post treatment. Quality of Life questionnaires and adverse even... Read More
Gender:
ALL
Ages:
9 years and above
Trial Updated:
11/14/2024
Locations: Loma Linda University Health, Loma Linda, California
Conditions: Refractory Epilepsy, Focal Seizure, Seizures, Focal, Seizures, Epilepsy in Children, Epilepsy, Epilepsy, Tonic-Clonic
Evaluating the Effects of Tasimelteon Vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
Recruiting
This is a multicenter, double-blind, randomized study to evaluate the efficacy and safety of a daily single oral dose of tasimelteon and matching placebo in male and female participants with DSWPD.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/14/2024
Locations: Vanda Investigational Site, Los Angeles, California
Conditions: Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
Vaginal Changes After CO2 Laser
Recruiting
Genitourinary syndrome of menopause (GSM) occurs due to a decline in estrogen levels as a woman approaches menopause. The syndrome negatively impacts women's quality of life and is characterized by vaginal dryness, burning, diminished lubrication, painful intercourse and urinary symptoms such as frequency and urgency. GSM is diagnosed by symptom assessment and physical exam, with current mainstay of treatment being vaginal estrogen. Women with a history of breast cancer, gynecologic cancer, or v... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Beckman Laser Institute, Irvine, California
Conditions: Genitourinary Syndrome of Menopause
Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
Recruiting
The goal of this observational study is to determine whether a marker of dead space (the end-tidal to alveolar dead space fraction \[AVDSf\]) is more strongly associated with mortality risk than markers of oxygenation abnormality (oxygenation index) and to determine whether dead space (AVDSf) is an important marker of heterogeneity in the inhaled nitric oxide (iNO) treatment effect for children with acute respiratory distress syndrome (ARDS). The study aims are: 1. To validate AVDSf for risk s... Read More
Gender:
ALL
Ages:
Between 0 years and 21 years
Trial Updated:
11/13/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Acute Respiratory Distress Syndrome
Training for Urinary Leakage Improvement After Pregnancy
Recruiting
This is a multi-center, randomized single-blind nonsurgical trial conducted in approximately 216 primiparous postpartum women at high risk for prolonged/sustained pelvic floor disorders with symptomatic, bothersome urinary incontinence (UI) amenable to nonsurgical treatment. TULIP is a 3-Arm trial with two active interventions (Arms 1 and 2) and a Patient Education control arm (Arm 3). Arm 1 consists of pelvic floor muscle training (PFMT). Arm 2 uses a home biofeedback device (leva®). The prim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Kaiser Permanente -- San Diego, San Diego, California
Conditions: Urinary Incontinence, Delivery Complication
Blood Specimen Collection For Laboratory Assay Research
Recruiting
To collect lab data from capillary and venous blood specimens for use in analytical research studies to support the development and validation of laboratory procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Roman Health Ventures Study Site, San Francisco, California
Conditions: General; Metabolic Disorder, Sexual Dysfunction, Hair Loss, Pathology
Crisis Response Planning for Military Personnel
Recruiting
The study is a randomized trial comparing outcomes of active duty service members who present to the emergency department at risk for suicide and receive care from providers trained in crisis response planning versus those providing treatment as usual.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Naval Medical Center San Diego, San Diego, California
Conditions: Suicidal, Suicide Threat, Suicidal Ideation
Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis
Recruiting
The goal of this study is to test the safety of drug, Belantamab Mafodotin, and see what effects (good and bad) it has on people who take it and amyloidosis, and to determine the most effective dose of the drug. The study will have 2 phases (parts). The first phase of the study will test different doses of Belantamab Mafodotin. The second phase will test Belantamab Mafodotin at the dose level found to be safe and effective in phase 1
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Stanford Cancer Institute, Stanford, California
Conditions: AL Amyloidosis, Amyloidosis
Compassion Meditation vs. Health Education for Veterans
Recruiting
Chronic pain (CP) is a major health problem for military Veterans, and CP is often associated with comorbid mental health problems, including posttraumatic stress disorder (PTSD) and depression. CP with psychological comorbidity is associated with increased healthcare costs, medication use, risk of suicide and rates of disability and reduced quality of life. Current empirically supported treatments do not always lead to substantial improvements (up to 50% of patients drop out or are do not respo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Chronic Pain, Stress Disorders, Posttraumatic, Depression
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia
Recruiting
To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.
Gender:
ALL
Ages:
10 years and above
Trial Updated:
11/13/2024
Locations: Goodman Eye Center, San Francisco, California
Conditions: Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Ectasia