California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers
Recruiting
This clinical trial compares telephone-based physical activity coaching to self monitored physical activity for improving physical function in older adults who are undergoing surgery for lung cancer and their caregivers. Lung cancer surgery in older adults is associated with functional declines and unique challenges. Performing physical activity around the time of surgery has been shown to improve functional outcomes in patients and exercise programs delivered via telehealth may improve access a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: University of California, Davis, California
Conditions: Lung Carcinoma
Investigating the Use of Intravenous Tranexamic Acid in Gender Affirming Mastectomy
Recruiting
Gender affirming surgeries (GAS) have been steadily increasing in the US, with the gender affirming mastectomy (GAM) being the most common surgery performed. Complications associated with these surgeries include hematoma and seroma. Prior studies in orthopedics, plastic surgery, and trauma have shown significant reduction of bleeding and ecchymosis with the use of tranexamic acid (TXA). TXA is a synthetic amino acid that blocks plasminogen conversion to plasmin, to stabilize clot formation. The... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: UCSF Department of Plastic & Reconstructive Surgery, San Francisco, California
Conditions: Postoperative Hematoma, Postoperative Seroma
Study of Inupadenant (EOS100850) with Chemotherapy As Second Line Treatment for Nonsquamous Non-small Cell Lung Cancer
Recruiting
The study will first determine the optimal dose of inupadenant to be given in combination with carboplatin and pemetrexed to patients that progressed after receiving first line anti-PD(L)1 treatment for locally advanced or metastatic non-small cell lung cancer. The efficacy and safety of the combination is then compared to standard of care carboplatin and pemetrexed in the same populations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Innovative Clinical Research Institute (ICRI), Whittier, California
Conditions: Metastatic NSCLC - Non-Small Cell Lung Cancer, Locally Advanced NSCLC - Non-Small Cell Lung Cancer
Aging and Reward System Response to Inflammation and Anxiety Study
Recruiting
The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation. Loss of pleasure or loss of motivation will be evaluated using self-report questionnaires, computer tasks, and during a brain scan.
Gender:
ALL
Ages:
Between 60 years and 80 years
Trial Updated:
09/04/2024
Locations: Norman Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, California
Conditions: Anhedonia, Inflammation, Anxiety, Aging, Depression
Using Nicotine to Reverse Age-related Auditory Processing Deficits
Recruiting
The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety o... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
09/04/2024
Locations: Hearing and Speech Lab, Irvine, California
Conditions: Auditory Perceptual Impairment, Aging
Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy
Recruiting
We have recently developed and optimized a vaginal Optical Coherence tomography/angiography endoscopy imaging system. This technology is able to obtain a comprehensive image of the vaginal epithelium, blood vessels, and lamina propria. The primary focus of this study is establishing the Optical Coherence Tomography system's capability of capturing vaginal changes that occur before and after menopause, as well as before and after treatment with fractional-CO2 laser therapy. There are two aims of... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Beckman Laser Institute and Medical Clinic, Irvine, California
Conditions: Genitourinary Syndrome of Menopause
Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome
Recruiting
Individuals with Sturge-Weber Syndrome (SWS) sometimes have brain involvement which can result in seizures, stroke-like episodes and neurologic deficits. The purpose of this study is to integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. The research aims are: 1. To integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. 2. Identify plasma and imaging biomarkers sensitive to ex... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/04/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Sturge-Weber Syndrome
Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer
Recruiting
This prospective, multicenter, 1:1 randomized, controlled trial is designed to evaluate the safety and effectiveness of the Breast Cancer Locator (BCL) in subjects with non-palpable invasive breast cancer or ductal carcinoma in situ (DCIS). Subjects will be randomized to breast conserving surgery (BCS) utilizing either the BCL or wire localization (WL) to guide surgery.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: BASS Medical Group, Walnut Creek, California
Conditions: Breast Cancer Female
Treatment of Disturbed Sleep in Progressive Supranuclear Palsy (PSP)
Recruiting
Prior research has identified profound sleep disruption in individuals with PSP. Not only were these individuals sleeping relatively short periods at night, they were also not recuperating lost sleep during the day. Research also showed the relative preservation of a series of nuclei key in regulating wake and arousal. Investigators believe that therapeutically targeting wake promoting centers with a specific medication will improve sleep quality and overall well-being in PSP. To study this, inv... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: University of California- San Francisco, San Francisco, California
Conditions: Treatment
The Effects of Core Shamanism in Fibromyalgia
Recruiting
This study aims to determine the feasibility of a shamanism intervention for patients with fibromyalgia, acquire efficacy data to determine if Shamanism reduces clinical pain and other common symptoms associated with fibromyalgia, and determine if the Shamanism intervention changes heart rate electrocardiogram (ECG), breathing rate, and brain wave electroencephalogram (EEG) outcomes in fibromyalgia patients and shamanic practitioners. The investigators hypothesize that 80% of individuals will c... Read More
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
09/03/2024
Locations: Susan Samueli Integrative Health Institute, Irvine, California
Conditions: Fibromyalgia
A Single Session Community-Based Body Empowerment Session
Recruiting
This present study will examine the effectiveness of a single session, virtually delivered body empowerment program for decreasing participants thin ideal internalization. The intervention asks participants to identify cultural norms surrounding appearance and attractiveness, then challenge these ideals. Participants will answer questions about thin ideal internalization before and after the program.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/03/2024
Locations: Equip Health, Carlsbad, California
Conditions: Body Image
The PREDICT Registry:
Recruiting
This is a prospective, non-interventional (observational) cohort study conducted within the medical network of the participating investigators and institutions. Patients meeting the eligibility criteria (see below) will be eligible for participation and the investigators will obtain written informed consent. A central Institutional Review Board (IRB), WCG IRB, will approve the protocol and each participating institution.
Gender:
FEMALE
Ages:
Between 30 years and 85 years
Trial Updated:
09/03/2024
Locations: Sutter Institute for Medical Research, Sacramento, California
Conditions: DCIS