California is currently home to 5581 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Patient-centered and Neurocognitive Outcomes with Acetazolamide for Sleep Apnea
Recruiting
Obstructive sleep apnea (OSA) is a severe type of snoring causing people to choke in their sleep. It affects millions of Americans, causing many health problems. For example, patients with OSA often feel very sleepy and are at risk of falling asleep while driving. OSA also causes elevated blood pressure, memory problems and can severely affect quality of life. Patients with OSA are often treated with a face-mask that helps them breath at night but can be difficult to tolerate. In fact, about hal... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: UC San Diego; Altman Clinical and Translational Research Institute Building, La Jolla, California
Conditions: Obstructive Sleep Apnea
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
Recruiting
The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive PACT plus 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will occur at baseline, 2 weeks, 4 weeks, and 8 weeks. Researchers will compare the PACT+iTBS group to the PACT+sham iTBS group to s... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/01/2024
Locations: UCSD, La Jolla, California
Conditions: Depression, Mild Traumatic Brain Injury, Concussion, Brain
ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC
Recruiting
In this Phase 2 study, mCRPC patients with PSMA positive scans who progressed on prior ARTA and up to 2 lines of taxanes, and are naïve to lutetium Lu 177 vipivotide tetraxetan, will be enrolled. The study is open-label, randomized with active control, multi-center study.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: University of California at Davis Cancer Center - 1624, Davis, California
Conditions: Metastatic Castration-resistant Prostate Cancer
4D-150 in Patients with Neovascular (Wet) Age-Related Macular Degeneration
Recruiting
Phase 1/2 dose-escalation and randomized, controlled, masked expansion trial in adults with wet AMD undergoing active anti-VEGF treatment
Gender:
ALL
Ages:
50 years and above
Trial Updated:
11/01/2024
Locations: California Retina Consultants, Oxnard, California
Conditions: Neovascular (Wet) Age-Related Macular Degeneration
Understanding Immunity to the Flu Vaccine in COVID-19 Patients
Recruiting
The purpose of this study is to measure immunity to the flu vaccine over time in patients who have had COVID-19 and may have other medical conditions including obesity, type 2 diabetes, chronic fatigue, or long-term COVID-19 symptoms. Adults and children (age 13 to 64) who had been diagnosed with COVID-19 as well as controls without COVID-19 will be invited to participate in this study.
Gender:
ALL
Ages:
Between 13 years and 64 years
Trial Updated:
11/01/2024
Locations: Stanford University, Palo Alto, California
Conditions: Corona Virus Infection, Flu Vaccine, Immunity
Oxaloacetate for the Improvement of Cognitive Complaints in Stage 0-IIIA Breast Cancer Survivors
Recruiting
This phase II trial studies how well oxaloacetate works in reducing cognitive complaints in stage 0-IIIA breast cancer survivors. Oxaloacetate is a natural substance found in the body and is available as a nutritional supplement. Giving oxaloacetate may reduce inflammation in the brain that could be contributing to cognitive complaints seen after cancer treatments.
Gender:
FEMALE
Ages:
Between 18 years and 74 years
Trial Updated:
11/01/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Early-Stage Breast Carcinoma, Prognostic Stage 0 Breast Cancer AJCC v8, Prognostic Stage I Breast Cancer AJCC v8, Prognostic Stage IA Breast Cancer AJCC v8, Prognostic Stage IB Breast Cancer AJCC v8, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8
Effect of Anti-inflammatory Diet in Osteoarthritis
Recruiting
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: University of California, San Diego, California
Conditions: Osteoarthritis, Knee
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
Recruiting
This is a single site, double-blind, placebo-controlled, crossover trial to quantify the effects of combination adjunctive therapy on glycemic control, ketogenesis during insulinopenia, insulin resistance, and diabetes burden and quality of life.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
10/31/2024
Locations: UC San Diego Altman Clinical & Translational Research Institute, La Jolla, California
Conditions: Type 1 Diabetes
Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in Pediatric PID Patients (KIDCARES10)
Recruiting
The purpose of this study is to assess efficacy, safety and pharmacokinetics of Kedrion Immunoglobulin 10% (KIg10) in pediatric patients with Primary Immunodeficiency Disease (PID).
Gender:
ALL
Ages:
Between 2 years and 16 years
Trial Updated:
10/31/2024
Locations: Velocity Clinical Research - MedPharmics - Lafayette, Chula Vista, California
Conditions: Primary Immunodeficiency Disease
Clinical Trial of a Novel Small Molecule EBNA1 Inhibitor, VK 2019, in Patients With Epstein Barr Virus (EBV)-Positive Nasopharyngeal Cancer (NPC) and Other Epstein-Barr Virus (EBV)-Associated Cancers, With Pharmacokinetic and Pharmacodynamic Correlative Studies
Recruiting
To evaluate the anti cancer effect of VK 2019 in subjects with EBV related nasopharyngeal carcinoma (NPC) for whom there is no other standard treatment available
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: Stanford University, Stanford, California
Conditions: Nasopharyngeal Cancer, Epstein-Barr Virus Related Carcinoma
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
Recruiting
The primary objective of this study is to determine if the peri and post operative use of gabapentin in children reduces the need for narcotics after thoracic surgery. We hypothesize that patients who are given gabapentin will need fewer morphine equivalents postoperatively than those who were not given gabapentin
Gender:
ALL
Ages:
17 years and below
Trial Updated:
10/31/2024
Locations: UC Davis Medical Center, Sacramento, California
Conditions: Pain, Postoperative
Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Recruiting
This is a multicenter, non-interventional study to observe the natural progression of the disease and to study the prevalence of pre-existing antibodies to AAV9 used for gene therapy in a population of patients with PKP2 gene-associated ARVC. Participation from all patients is encouraged regardless of interest in or eligibility for gene therapy.
Gender:
ALL
Ages:
Between 14 years and 65 years
Trial Updated:
10/30/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy