California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Clinical and Basic Investigations Into Congenital Disorders of Glycosylation
Recruiting
The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.
Gender:
ALL
Ages:
All
Trial Updated:
11/07/2024
Locations: Rady Children's Hospital, San Diego, California
Conditions: Congenital Disorders of Glycosylation
Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy
Recruiting
This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will undergo PET scans of the brain at two weeks and two months after injury to measure neuro-inflammation. The results of the PET scans will be analyzed and correlated with the risk of post-traumatic epilepsy.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/07/2024
Locations: University of California, Davis, Sacramento, California
Conditions: Epilepsy, Post-Traumatic
Controlled Desaturation Study for Perin Health Patch Validation
Recruiting
This study aims to test the accuracy of the Perin Health Patch (PHP), a non-invasive, chest-worn device that measures blood oxygen levels, by comparing its readings to a standard pulse oximeter device. The PHP device uses light sensors to measure blood oxygen saturation (SpO2), similar to how standard pulse oximeters work, and could allow for continuous remote monitoring at home. Participants in this study will breathe low-oxygen air through a mask to simulate different oxygen levels in a contro... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/06/2024
Locations: Perin Health Devices, Woodland Hills, California
Conditions: Oxygen Saturation Measurement
Oxybutynin for Post-surgical Bladder Pain and Urgency
Recruiting
Bladder pain and urgency are common after bladder surgery. The objective is to determine if transdermal administration is superior to oral administration in alleviating pain and urgency.
Gender:
ALL
Ages:
Between 4 years and 8 years
Trial Updated:
11/06/2024
Locations: University of California Davis Medical Center (UCDMC), Sacramento, California
Conditions: Overactive Bladder Syndrome, Neuropathic Bladder
Accuracy of Pulse CO-Oximetry Technology in Characterizing Noninvasive SpHb
Recruiting
This protocol is a request from Masimo to assist in the collection of data to be used to further refine the accuracy of the monitor's algorithm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/06/2024
Locations: UC Davis Health, Sacramento, California
Conditions: Surgery, Hemoglobin
Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Their Family Care Givers
Recruiting
This clinical trial evaluates the impact of telehealth self-management coaching sessions on quality of life in pancreatic cancer survivors and their family care givers (FCGs). Patients with pancreatic cancer experience many symptoms because of the disease and treatment, which can have a negative impact on quality of life. Patients and their families have unmet needs during treatment, including a lack of quality of life programs that offer support to patients. Supporting patients and families on... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: City of Hope at Arcadia, Arcadia, California
Conditions: Metastatic Pancreatic Adenocarcinoma
FID-007 and Cetuximab in Treating Patients With Advanced Head and Neck Squamous Cell Carcinoma
Recruiting
The goal of this FID-007 Clinical Trial is to compare the efficacy of different dosing regimens of FID-007 in combination with Cetuximab in patients with recurrent or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC). The main questions it aims to answer are: to evaluate the efficacy, and to characterize the safety and tolerability. Eligible participants will be enrolled and randomized to 1 of 2 arms of FID-007 with fixed-dose Cetuximab in each 28-day cycle.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California
Conditions: Head and Neck Squamous Cell Carcinoma
Outcomes of Running Locking Suture vs Standard Running Suture in Surgical Wounds
Recruiting
When patients have surgery on the head and face, stitches are the standard way to close the wound. Wounds always result in a scar, but doctors are always looking for ways to reduce scarring. Several studies have been done to test ways to close wounds that reduce scarring. The most commonly performed closure technique uses running sutures, where a single strand of suture is continued along the length of the wound with a series of uninterrupted stiches. However, alternative closure techniques exis... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: University of California, Davis - Dermatology Department, Sacramento, California
Conditions: Scarring
Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome
Recruiting
This phase I trial tests the side effects and best dose of total marrow lymphoid irradiation along with chemotherapy, with fludarabine and melphalan, with or without thiotepa, in combination with Orca-T cells for patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) or myelodysplastic syndrome (MDS). Total marrow and lymphoid irradiation is a targeted form of total body irradiation that uses intensity-modulated radiation therapy to target marrow, lymph node chains, and t... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
11/05/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Myelodysplastic Syndrome
Evaluation of Oral Potentially Malignant Disorders (OPMDs) with STRATICYTE™
Recruiting
The purpose of this study is to validate the ability of the STRATICYTE™ predictive model to predict the transformation of oral potentially malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC) in a retrospective cohort of patients who received biopsies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Loma Linda University, Loma Linda, California
Conditions: Mouth Diseases
Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma
Recruiting
This early phase I clinical trial evaluates bridging radiation therapy given before chimeric antigen receptor (CAR) T-cell infusion to treat large B-cell lymphoma (LBCL) that has come back (relapsed) or has not responded to previous treatment (refractory). Patients with relapsed or refractory disease have historically poor prognosis. CAR T-cell therapy is a type of treatment in which a patient's T-cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Recurrent Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
Patient Specific Talus Spacer Post Approval Study
Recruiting
Humanitarian Device Exemption Approved Patient Specific Talus Spacer Post Approval Study.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/05/2024
Locations: Redwood Orthopaedics, Santa Rosa, California
Conditions: Avascular Necrosis of the Talus