California is currently home to 5616 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Lenrispodun as Adjunctive Therapy in the Treatment of Patients With Motor Fluctuations Due to Parkinson's Disease
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed-dose study in patients with a diagnosis of Parkinson's Disease consistent with the UK Parkinson's Disease Society (UKPDS) Brain Bank diagnostic criteria, who are experiencing wearing off symptoms and levodopa-induced dyskinesia.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
10/21/2024
Locations: Clinical Site, Irvine, California
Conditions: Parkinson Disease
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)
Recruiting
The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, in pediatric participants with Canavan disease.
Gender:
ALL
Ages:
30 months and below
Trial Updated:
10/21/2024
Locations: UCSF Benioff Children's Hospital Oakland, Oakland, California
Conditions: Canavan Disease
Administration of Allogeneic-MSC in Patients with Non-Ischemic Dilated Cardiomyopathy
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called human allogeneic mesenchymal stem cell therapy.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/21/2024
Locations: Stanford University, Stanford, California
Conditions: Non-ischemic Dilated Cardiomyopathy
Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor
Recruiting
The purpose of this study is to evaluate the safety and clinical activity of nivolumab and relatlimab in patients with microsatellite instability high (MSI-H) solid tumors refractory to prior PD-(L)1 therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/21/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Refractory MSI - H Solid Tumors Prior of PD-(L) 1 Therapy, MSI-H Tumors
An Evaluation of LASIK, SMILE and PRK Surgery in Physicians
Recruiting
The principle investigator is evaluating self-reported quality of vision and quality of life in physicians undergoing LASIK, SMILE and PRK surgery.
Gender:
ALL
Ages:
Between 21 years and 62 years
Trial Updated:
10/21/2024
Locations: Byers Eye Institute at Stanford, Palo Alto, California
Conditions: Nearsightedness, Farsightedness, Astigmatism
Early vs. Late Time-Restricted Eating in Adolescents With Obesity (EL TREA)
Recruiting
Determine the effectiveness of how limiting the time you eat within an early or late eating window and fasting for remainder of the day will impact weight loss and body mass index (BMI).
Gender:
ALL
Ages:
Between 12 years and 21 years
Trial Updated:
10/19/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Pediatric Obesity, Time Restricted Feeding, Time Restricted Eating
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors
Recruiting
This study examines the impact of social and genetic factors on outcomes in adolescent and young adult (AYA) cancer survivors of Hodgkin or non-Hodgkin lymphoma. Compared to both older adult and childhood cancer patients, AYAs with cancer experience different diagnoses and specific biological, clinical, psychological and social factors that affect their risks for post-treatment morbidity and premature death. Collecting samples of blood samples and health and treatment information from cancer sur... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: PCR Oncology, Arroyo Grande, California
Conditions: Hodgkin Lymphoma, Non-Hodgkin Lymphoma
First in Human Study of TORL-3-600 in Participants With Advanced Cancer
Recruiting
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-3-600 in patients with advanced cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: Providence Medical Foundation, Fullerton, California
Conditions: Advanced Solid Tumor, Colorectal Cancer
Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy
Recruiting
To use a consistent and standardized platform to retrospectively and prospectively study children and young adults with B cell malignancies receiving Immunotherapy, blinatumomab and/or inotuzumab ozogamicin.
Gender:
ALL
Ages:
26 years and below
Trial Updated:
10/17/2024
Locations: Stanford University, Palo Alto, California
Conditions: Lymphoid Leukemia
Weighted Blankets for Postsurgical Pain
Recruiting
The strongest psychological predictor of persistent pain after surgery is anxiety before surgery. The weight of blanket a person uses overnight may alter both anxiety and pain levels. The proposed study will determine whether a heavier or lighter blanket alters presurgical anxiety or postsurgical pain in individuals undergoing a breast surgery. We will also study whether any blanket-induced changes in postsurgical pain are related to reductions in anxiety before surgery induced by the blanket. F... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/17/2024
Locations: Actri, Ucsd, La Jolla, California
Conditions: Pain, Postsurgical
MiSight 1 Day Post-Approval Study for Effectiveness and Visual Symptoms
Recruiting
The purpose of this post-approval study is to confirm the effectiveness of the MiSight 1 Day lens in clinical practices within the US and to assess the stability of the myopia reduction over one-year post-treatment.
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
10/17/2024
Locations: Marshall B. Ketchum University Southern California College of Optometry, Fullerton, California
Conditions: Myopia
Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety
Recruiting
The purpose of this study is to determine the safety and feasibility of the Magnap magnetic device in the treatment of obstructive sleep apnea (OSA).
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
10/17/2024
Locations: University of California San Francisco/Mount Zion Hospital, San Francisco, California
Conditions: Obstructive Sleep Apnea